Interference-free and high precision biosensor based on surface enhanced Raman spectroscopy integrated with surface molecularly imprinted polymer technology for tumor biomarker detection in human blood

Lin, Xueliang; Wang, Yunyi; Wang, Lingna; Lu, Yue; Jin, Li; Lu, Dechan; Zhou, Ting; Huang, Zufang; Huang, Jun; Huang, Huifang; Qiu, Sufang; Chen, Rong; Lin, Duo; Feng, Shouhua

doi:10.1016/j.bios.2019.111599

Cited by 75 publications

(44 citation statements)

References 37 publications

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“…In this regard, there have already been some successful demonstrations of substrates with combined functionalities. 94,199,202,208,213 In addition, other important metrics, such as suitability for automated mass production and stability during storage must also be taken into consideration. While the importance of these properties has been recognized to some degree by the SERS community, 162,[279][280][281] more rigorous standards must be established in order to facilitate the routine application of SERS in practice.…”

Section: Discussionmentioning

confidence: 99%

“…Lin, Feng, et al demonstrated that 4mercaptobenzonitrile could be used as an internal standard to significantly improve the SERS quantitative performance of Au nanoparticles. 202 Similar to Prussian blue, the 4mercaptobenzonitrile contained C≡N functional groups, which when functionalized on the enhancing surface of the Au nanoparticles generated an intense and distinct vibration band at 2224 cm -1 in the Raman silent region of the spectra. As shown in Figure 14C spectra set i, this led to a significant improvement of the precision of the indirect SERS quantification of a tumour marker, carcinoembryonic antigen in clinical serum samples (Figure 14C spectra set ii-iii).…”

Section: Calibration With Adsorbed Self-assembled Monolayersmentioning

confidence: 99%

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Towards practical and sustainable SERS: a review of recent developments in the construction of multifunctional enhancing substrates

Huang

et al. 2021

J. Mater. Chem. C

136

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Section: Discussionmentioning

confidence: 99%

Section: Calibration With Adsorbed Self-assembled Monolayersmentioning

confidence: 99%

Towards practical and sustainable SERS: a review of recent developments in the construction of multifunctional enhancing substrates

Huang

et al. 2021

J. Mater. Chem. C

136

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“…1212, 1400, and 1572 cm -1 ) of the field banana samples did not always perfectly match the Raman peaks of the Foc mycelia, microconidia, and macroconidia because it is easy for Raman peaks (300-1800 cm −1 ) to be interfered with by the Raman signals from endogenous biomolecules [39]. Before this study, Raman spectroscopy had not been used for the diagnosis of banana diseases.…”

Section: Plos Onementioning

confidence: 92%

Construction of Raman spectroscopic fingerprints for the detection of Fusarium wilt of banana in Taiwan

Lin

2020

PLoS ONE

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Banana (Musa sp.) is cultivated worldwide and is one of the most popular fruits. The soilborne fungal disease Fusarium wilt of banana (FWB), commonly known as Panama disease, is caused by Fusarium oxysporum f. sp. cubense (Foc) and is a highly lethal vascular fungal disease in banana plants. Raman spectroscopy, an emerging laser-based technology based on Raman scattering, has been used for the qualitative characterization of biological tissues such as foodborne pathogens, cancer cells, and melamine. In this study, we describe a Raman spectroscopic technique that could potentially be used as a method for diagnosing FWB. To that end, the Raman fingerprints of Foc (including mycelia and conidia) and Foc-infected banana pseudostems with varying levels of symptoms were determined. Our results showed that eight, eleven, and eleven characteristic surface-enhanced Raman spectroscopy peaks were observed in the mycelia, microconidia, and macroconidia of Foc, respectively. In addition, we constructed the Raman spectroscopic fingerprints of banana pseudostem samples with varying levels of symptoms in order to be able to differentiate Foc-infected bananas from healthy bananas. The rate at which FWB was detected in asymptomatic Foc-infected samples by using the spectral method was 76.2%, which was comparable to the rates previously reported for other FWB detection methods based on real-time PCR assays, suggesting that the spectral method described herein could potentially serve as an alternative tool for detecting FWB in fields. As such, we hope that the developed spectral method will open up new possibilities for the on-site diagnosis of FWB.

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“…Chang et al demonstrated a sensitive immunoassay using SERS active nanoparticles which were sufficiently sensitive and photostable to be detected at the single probe level [ 187 ]. Combining SERS technology with surface molecularly imprinted polymer (MIP) technology, a novel biosensor was fabricated for CEA detection by Lin et al [ 188 ]. Taking advantage of surface molecularly imprinted polymer, recognition sites with high affinity to the analyte enhanced stable and specific capture ability.…”

Section: Other Biomarker Sensorsmentioning

confidence: 99%

Recent Progress of Biomarker Detection Sensors

Liu

Cui

2020

Research

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Early cancer diagnosis and treatment are crucial research fields of human health. One method that has proven efficient is biomarker detection which can provide real-time and accurate biological information for early diagnosis. This review presents several biomarker sensors based on electrochemistry, surface plasmon resonance (SPR), nanowires, other nanostructures, and, most recently, metamaterials which have also shown their mechanisms and prospects in application in recent years. Compared with previous reviews, electrochemistry-based biomarker sensors have been classified into three strategies according to their optimizing methods in this review. This makes it more convenient for researchers to find a specific fabrication method to improve the performance of their sensors. Besides that, as microfabrication technologies have improved and novel materials are explored, some novel biomarker sensors—such as nanowire-based and metamaterial-based biomarker sensors—have also been investigated and summarized in this review, which can exhibit ultrahigh resolution, sensitivity, and limit of detection (LoD) in a more complex detection environment. The purpose of this review is to understand the present by reviewing the past. Researchers can break through bottlenecks of existing biomarker sensors by reviewing previous works and finally meet the various complex detection needs for the early diagnosis of human cancer.

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Interference-free and high precision biosensor based on surface enhanced Raman spectroscopy integrated with surface molecularly imprinted polymer technology for tumor biomarker detection in human blood

Cited by 75 publications

References 37 publications

Towards practical and sustainable SERS: a review of recent developments in the construction of multifunctional enhancing substrates

Towards practical and sustainable SERS: a review of recent developments in the construction of multifunctional enhancing substrates

Construction of Raman spectroscopic fingerprints for the detection of Fusarium wilt of banana in Taiwan

Recent Progress of Biomarker Detection Sensors

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