Interference of ISEcp1-blaCTX-M-1 with the shufflon rearrangement in IncI1 plasmids

Stosic, Milan S.; Sunde, Marianne; Mo, Solveig Sølverød; Telke, Amar A.; Rudi, Knut

doi:10.1016/j.plasmid.2021.102578

Cited by 1 publication

(1 citation statement)

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“…It is widely known that shufflon is a multiple-inversion system that is closely related to the efficiency of the conjugation [ 52 ]. Shufflon comprises four segments (A, B, C, and D) which may be rearranged and inverted to influence the conjugation during liquid mating [ 53 ]. The rearrangement of shufflon usually reduces the transfer frequency instead of the loss [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Genome Assessment of Carbapenem- and Colistin-Resistant Escherichia coli from Patients in a Sentinel Hospital in China

Tang

Lin

et al. 2022

Cells

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Antimicrobial-resistant (AMR) pathogens are a significant threat to public health worldwide. However, the primary carrier of AMR genes, particularly against last-resort antibiotics, is still only partially studied in Chinese hospitals. In a sentinel hospital in China, we collected 157 E. coli strains from patients between January and July 2021. One blaNDM-1-, nine blaNDM-5-, and one mcr-1-positive E. coli recovered from inpatients were identified as resistant to meropenem and colistin. There are 37 virulence genes discovered in the 11 strains, including astA in strain EC21Z-147 (O128: H4), which belongs to the enteroaggregative E. coli (EAEC). The blaNDM gene is distributed into distinct ST types, including ST48, ST616, ST410, ST711, and ST2003, while the mcr-1 gene was identified in ST117. The conjugative plasmids IncX3, IncI1-I, and IncI2 mediated the blaNDM-5 and mcr-1 genes detected among inpatients. Notably, the youngest age at which mcr-1-positive E. coli has been reported was at one day old, in a child in which the strain is closely related to strains with animal origins. Hospitals are major environments for the spread and dissemination of critical virulence and AMR genes, which requires active monitoring systems at the genome level to surveil the spread of virulence and AMR.

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Section: Discussionmentioning

confidence: 99%