Efficient fiber-based long-distance quantum communication via quantum repeaters relies on deterministic single-photon sources at telecom wavelengths, with the potential to exploit the existing world-wide infrastructures. For upscaling the experimental complexity in quantum networking, two-photon interference (TPI) of remote non-classical emitters in the low-loss telecom bands is of utmost importance. With respect to TPI of distinct emitters, several experiments have been conducted, e.g., using trapped atoms [1], ions [2], NV-centers [3, 4], SiV-centers [5], organic molecules[6] and semiconductor quantum dots (QDs) [7][8][9][10][11][12][13][14]; however, the spectral range was far from the highly desirable telecom C-band. Here, we report on TPI at 1550 nm between down-converted single photons from remote QDs [15], demonstrating quantum frequency conversion [16][17][18] as precise and stable mechanism to erase the frequency difference between independent emitters. On resonance, a TPI-visibility of (29 ± 3) % has been observed, being only limited by spectral diffusion processes of the individual QDs [19,20]. Up to 2-km of additional fiber channel has been introduced in both or individual signal paths with no influence on TPI-visibility, proving negligible photon wave-packet distortion. The present experiment is conducted within a local fiber network covering several rooms between two floors of the building. Our studies pave the way to establish long-distance entanglement distribution between remote solid-state emitters including interfaces with various quantum hybrid systems [21][22][23][24].