Interferon-beta-induced changes in neuroimaging phenotypes of appetitive motivation and reactivity to emotional salience

Abstract

HighlightsOur study highlights the use of neuroimaging methods to detect and analyze therapy associated side effects, and the main finding of our study is that interferon, known to induce depression as adverse drug effect, leads to selective blunting of appetitive rather than affective stimuli.Our study shows the utility of sophisticated imaging methods to assess and clarify the nature of subtle drug effects on emotional and cognitive behavior.We think that the use of neuroimaging methods for the prediction and detection of off-target drug effects on mental health is an important topic in personalized medicine.

Negative Cognitions in the Personality Domains of the AMPD

“…Detachment is thought to reflect the diminished receptivity to appetitive incentives provided by the environment, which motivate efforts to attain hedonic or rewarding conditions in social or material contexts (Der-Avakian & Markou, 2012;Treadway & Zald, 2011). Activity in these two systems may be negatively correlated, as it is unusual to be simultaneously aroused by threat and appetitive incentives (although they may be dissociated in experimental conditions by a pharmacological manipulation, Coch et al, 2019).…”

Type 1 interferon mediates chronic stress-induced neuroinflammation and behavioral deficits via complement component 3-dependent pathway

“…Similarly, IFNβ treatment has been shown to trigger sickness behavior and depressive symptoms in MS patients ( 28 , 29 ). Also, IFNβ administration in healthy volunteers resulted in reduced appetitive motivation in psychopathology ratings ( 30 ). Further, increased IFN-I signaling has been reported in the blood of depressed subjects ( 31 ).…”