Interferon gamma +874 T/A polymorphism increases the risk of cervical cancer: evidence from a meta-analysis

Abstract

Data from previous studies about the association between interferon gamma (IFN-γ) +874 T/A (rs2430561) polymorphism and cervical cancer risk offer controversial results. To obtain a more dependable conclusion, this meta-analysis was performed. We selected eight articles including nine case-control studies with 1,116 cases and 1,290 controls, odds ratios (OR) with 95 % confidence intervals (CI) were used to assess the strength of the association. Subgroup analysis was carried out by ethnicity, source of controls, genotyping methods, and score of quality assessment. Our meta-analysis indicated that the IFN-γ (+874 T/A) polymorphism significantly increased the risk of cervical cancer in the codominant model (TA vs. TT: OR = 1.471, 95 % CI = 1.137-1.903, P = 0.003, I (2) % = 0.0, P Q = 0.785) and the dominant model (TA + AA vs. TT: OR = 1.399, 95 % CI = 1.097-1.784, P = 0.007, I (2) % = 0.0, P Q = 0.486) in the overall population. Stratified analysis by ethnicity indicated a significantly increased risk of cervical cancer in Asians in the codominant model (TA vs. TT: OR = 1.494, 95 % CI = 1.069-2.087, P = 0.019, I (2) % = 0.0, P Q = 0.440) and the dominant model (OR = 1.455, 95 % CI = 1.062-1.993, P = 0.019, I (2) % = 42.9, P Q = 0.154). Thus, the IFN-γ (+874 T/A) polymorphism is likely to increase the risk of cervical cancer. Because of the limited studies and sample sizes included in our meta-analysis, further well-designed and large-scale studies are demanded to confirm our results.

Is there an association between IFN-γ +874A/T polymorphism and periodontitis susceptibility?

“…[51] Moreover, it is still controversial about whether Interferon-γ +874A/T polymorphism could increase the cancer risk. Through a 9 study-based meta-analysis, Sun et al [49] found that IFN-γ +874A/T polymorphism was likely to increase the risk of cervical cancer, while Ge et al [54] concluded that IFN-γ +874A/T polymorphism may not contribute to cancer susceptibility. Hence, well-designed and large-scale studies are demanded.…”

Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk

“…Previous studies have showed the association between IFN-γ +874T/A polymorphism and cervical cancer, 35,36 bladder cancer, 37 liver cancer, 38 and breast cancer, 39 and suggested that T allele might be a protective genotype in cancer for TT genotype produces a high level of IFN-γ. Yet a recent meta-analysis showed no association between IFN-γ +874T/A polymorphism and cancer susceptibility, 40 at the same time, the other meta-analysis found positive association in cervical cancer and breast cancer, 23,26 which suggested that IFN-γ +874T/A polymorphism play different roles in different cancer types; therefore, the conclusion from a pooled analysis for association between IFN-γ +874T/A polymorphism and all cancer types may be unreliable. This meta-analysis confirmed this point.…”

“…21 Indeed, our finding is consistent with previous meta-analysis that T allele is a protect genotype among patients in breast cancer, cervical cancer, asthma, and leprosy. 23–26 …”

Tetrabromobisphenol A activates the hepatic interferon pathway in rats

“…Whether the uterus would respond similarly to TBBPA or other chemical exposures and engage IFN-dependent pathways is an untested hypothesis. IFN polymorphisms are associated with increased risk of cervical cancer (Sun et al, 2015) but the relationship of IFN-related mechanisms with uterine carcinogenesis requires further investigation.…”