Interferon gamma polymorphisms and hepatitis B virus-related liver cirrhosis risk in a Chinese population

Abstract

BackgroundPrevious studies proved that interferon gamma (IFN-γ) gene polymorphisms were associated with the risk of hepatitis B virus (HBV) infection. However, the association between IFN-γ polymorphisms and HBV-related liver cirrhosis (HBV-LC) risk is still unclear.MethodsIFN-γ +874 T/A and +2109G/A genotypes were determined in 126 HBV-LC patients, 129 chronic hepatitis B(CHB) patients, and 173 early HBV infection controls using a sequence-specific primer-polymerase chain reaction and a polymerase chain reaction-restriction fragment length polymorphism, respectively.ResultsSignificant associations were observed between +2109A/G polymorphisms and HBV-LC risk in the co-dominant model (GG vs. AA: OR = 0.321, 95% CI = 0.130-0.793, P = 0.014), the allelic model (OR = 0.565, 95% CI = 0.388-0.825, P = 0.003), the dominant model (OR = 0.551, 95% CI = 0.344-0.883, P = 0.013), and the recessive model (OR = 0.385, 95% CI = 0.159-0.930, P = 0.034). In addition, haplotype analysis indicated that the T+874G+2109 haplotype significantly decreased the HBV-LC risk (OR = 0.106, 95% CI = 0.022-0.502, P = 0.000), and A+874A+2109 haplotype significantly increased the LC risk (OR = 1.485, 95% CI = 1.065-2.070, P = 0.019). No significant associations were observed between IFN-γ +874 T/A polymorphisms and HBV-LC risk, as well as the two single-nucleotide polymorphisms (SNPs) and CHB risk (P > 0.05).ConclusionsOur observations suggested a significant association of IFN-γ polymorphisms with HBV-LC risk in the Chinese population.

Single Nucleotide Polymorphism of the Interferon-γ Gene (IFN-γ +874 T/A) and the Prognosis of Hepatitis B Infection

“…Therefore, the low IFNγ expression may reduce the host immune response to HBV, and these individuals are more prone to the infection. A study conducted by Sun and colleagues (2015) in a Chinese population revealed that IFN-γ +874T haplotype is potentially protective against persistent HBV infection [29]. Also in agreement with our results, in a rural area of Northern China IFN-γ+ 874 AA genotype showed to be associated with an increased risk of chronic HBV infection [30].…”

Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran

“…Cytokines represent a substantial role in initiating and maintaining a suitable immune and inflammatory response of HBV infection through direct or indirect inhibition of viral replication (15,(41)(42)(43)(44)(45)(46). Therefore, several recent studies have paid attention to the effect of gene polymorphisms of cytokines on infectious disease outcome, response to vaccination and treatment.…”

Genetic variant in visfatin gene promoter contributes to reduced risk of hepatocellular carcinoma in a Chinese population

“…The inclusion of members of the CHB group were indicated by the following findings: elevated serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels (> 40 IU/mL); or HBV-DNA levels > 1,000 copies/mL. HBV-LC was diagnosed as described in our previous study [36]. The patient inclusions were primarily based on imaging examinations, through ultrasonography, magnetic resonance imaging, computed tomography, and pathological examination.…”