Interferon-Induced Depression in Chronic Hepatitis C

Udina, Marc; Castellví, Pere; Moreno-España, J.; Navinés, Ricard; Valdés, Manuel; Forns, Xavier; Langohr, Klaus; Solá, Ricard; Vieta, Eduard; Martín‐Santos, Rocío

doi:10.4088/jcp.12r07694

Cited by 277 publications

(205 citation statements)

References 64 publications

Supporting

Mentioning

183

Contrasting

Unclassified

Order By: Relevance

“…Finally, patients treated with proinflammatory cytokines often develop depression. Treatment with interferon-γ, in particular, is associated with depression [41].…”

Section: The Contribution Of Inflammation To Depression and Fatiguementioning

confidence: 99%

“…The FAS has been validated in healthy cohorts [71]. FAS scores of 10-21 indicate that the patient is "not tired", scores of 22-34 indicate that the patient is "tired", and scores of [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] indicate that the patient is "very tired" [72]. We evaluated the relationship between the biomarkers of inflammation shown in Fig.…”

Section: Inflammation and The Biological Basis Of Psfmentioning

confidence: 99%

See 1 more Smart Citation

Inflammation and the Silent Sequelae of Stroke

Becker

2016

Neurotherapeutics

View full text Add to dashboard Cite

Depression and fatigue are common after stroke and negatively impact the quality of life of stroke survivors. The biological bases of these symptoms are unknown, but an abundance of data point to a role for inflammation. This review highlights evidence supporting the contribution of inflammation to poststroke depression and poststroke fatigue. Potential treatments for poststroke depression and poststroke fatigue are explored, with a special emphasis on those that modulate the immune response.

show abstract

“…Finally, patients treated with proinflammatory cytokines often develop depression. Treatment with interferon-γ, in particular, is associated with depression [41].…”

Section: The Contribution Of Inflammation To Depression and Fatiguementioning

confidence: 99%

Section: Inflammation and The Biological Basis Of Psfmentioning

confidence: 99%

Inflammation and the Silent Sequelae of Stroke

Becker

2016

Neurotherapeutics

View full text Add to dashboard Cite

show abstract

“…This hypothesis is informed by a number of observations demonstrating that depressive-like behavior is induced by administration of PICs. Interferon alpha (IFN-α) studies indicated that 28 % of hepatitis C patients developed a new onset major depressive episode during treatment with IFN-α [21]; the rate reported in malignant melanoma patients is 45 % [22]. Treatment with paroxetine prevents depressed mood, anxiety, and cognitive dysfunction, but not neurovegetative symptoms, associated with IFN-α treatment.…”

Section: Inflammation and Depressionmentioning

confidence: 99%

Sick and Tired: Mood, Fatigue, and Inflammation in Cancer

Kruse

Strouse

2015

Curr Psychiatry Rep

View full text Add to dashboard Cite

Cancer patients commonly experience depression and fatigue before, during, and after treatment. Symptoms can be debilitating, and the risks associated with unrecognized or inadequately treated depression are substantial. Inflammation may be important in the genesis of depression and fatigue in cancer patients; potential neurobiological mechanisms of inflammation-related behavioral symptoms are reviewed. Randomized studies of pharmacologic treatments for depression in cancer populations are limited, but available data are generally encouraging. Studies of pharmacologic treatments for cancer-related fatigue have been more numerous but with mixed results. A practical approach to pharmacologic treatment of depression and fatigue in cancer patients involves weighing the potential risks and benefits of specific agents, including potential for adverse or advantageous side effects. Progress in understanding the neurobiological mechanisms underlying inflammation-related behavioral symptoms will provide opportunities for the development of novel and targeted treatments.

show abstract

“…Using the Hospital Anxiety and Depression Scale, researchers described prevalence rates ranging from 27% 36 to 72.6% 37 , most likely due to differences in the assessment instruments and procedures. A meta-analysis 38 concluded that the presence of depressive symptoms at the beginning of anti-viral treatment enhances the incidence of major depression episodes during treatment and may have a negative impact on treatment adherence and outcome.…”

Section: Prevalence Of Depressive Symptoms and Harmful Alcohol Usementioning

confidence: 99%

Depressive symptoms and harmful alcohol use in hepatitis C patients: prevalence and correlates

Machado

Silva

Torres

et al. 2014

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction:It is important to understand the characteristics and vulnerabilities of people who have hepatitis C because this disease is currently an important public health problem. The objective of this study was to estimate the prevalence of depressive symptoms and harmful alcohol use in patients with hepatitis C and to study the association between these outcomes and demographic, psychosocial and clinical variables. Methods: This cross-sectional, descriptive and analytical study involved 82 hepatitis C patients who were being treated with pegylated interferon and ribavirin at a public university hospital. The primary assessments used in the study were the Alcohol Use Disorders Identifi cation Test and the Beck Depression Inventory. Bivariate analyses were followed by logistic regression. Results: The prevalence of depressive symptoms was 30.5% (n=25), and that of harmful alcohol use was 34.2% (n=28). Logistic regression analysis showed that individuals who were dissatisfi ed with their social support (OR=4.41; CI=1.00-19.33) and were unemployed (OR=6.31; CI=1.44-27.70) were at a higher risk for depressive symptoms, whereas harmful alcohol use was associated with the male sex (OR=6.78; CI=1. 38-33.19) and the use of illicit substances (OR=7.42; CI=1.12-49.00). Conclusions: High prevalence rates of depressive symptoms and harmful alcohol use were verifi ed, indicating vulnerabilities that must be properly monitored and treated to reduce emotional suffering in this population.

show abstract

Interferon-Induced Depression in Chronic Hepatitis C

Cited by 277 publications

References 64 publications

Inflammation and the Silent Sequelae of Stroke

Inflammation and the Silent Sequelae of Stroke

Sick and Tired: Mood, Fatigue, and Inflammation in Cancer

Depressive symptoms and harmful alcohol use in hepatitis C patients: prevalence and correlates

Contact Info

Product

Resources

About