Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis

Abstract

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Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs

“…Previous studies demonstrated that low levels of sphingosine are sufficient to treat or prevent pulmonary infections, at least in mice, in particular mice with cystic fibrosis [ 15 , 17 , 39 ]. Cystic fibrosis mice exhibit a constitutive decrease of sphingosine in bronchial epithelial cells, which is caused by an IRF-8-regulated down-regulation of acid ceramidase expression in Cftr-deficient bronchial epithelial cells [ 40 ]. The lack of sphingosine resulted in increased infection susceptibility of CF-mice, which was corrected by inhalation of sphingosine [ 40 ].…”

“…Cystic fibrosis mice exhibit a constitutive decrease of sphingosine in bronchial epithelial cells, which is caused by an IRF-8-regulated down-regulation of acid ceramidase expression in Cftr-deficient bronchial epithelial cells [ 40 ]. The lack of sphingosine resulted in increased infection susceptibility of CF-mice, which was corrected by inhalation of sphingosine [ 40 ].…”

Identification of Key Genes and Underlying Mechanisms in Cystic Fibrosis and its Associated Complications Based on Bioinformatics Analysis of Next Generation Sequencing Data Analysis

“…NTRK3 [81], MMP9 [82], IGF2 [83], SOCS3 [84], IGFBP2 [85], SLC1A3 [86], NOS1AP [87], HP (haptoglobin) [88], TLR5 [89], ARG1 [90], NRG1 [91], RGS5 [92], LCN2 [93], TSPO (translocator protein) [94], PLAU (plasminogen activator, urokinase) [95], MME (membrane metalloendopeptidase) [96], BST1 [97], NR6A1 [98], TLR4 [99], NRN1 [100], ABCA13 [101], CTSD (cathepsin D) [102], NCAM1 [103], SIGMAR1 [104], CNR2 [105], CCR4 [106], ABCB1 [107], TIMELESS (timeless circadian regulator) [108], IRF8 [109], TXNIP (thioredoxin interacting protein) [110], SUV39H1 [111], CRY1 [112], CRY2 [113], PDCD4 [114] and MGAT5 [115] played an important role in depression and anxiety. Accumulating evidence has demonstrated that MMP9 [116], S100A12 [117], HP (haptoglobin) [118], TLR5 [119], NRG1 [120], PLAU (plasminogen activator, urokinase) [121], SLC11A1 [122], AQP9 [123], CHIT1 [124], TLR4 [125], SLC26A8 [126], CTSD (cathepsin D) [127], SERPINB1 [128], FASLG (Fas ligand) [129], SLC4A4 [130], AQP3 [131] and IRF8 [132] appears to be constitutively associated with CF . MMP9 [133], S100A12 [134], SOCS3 [135], MMP8 [136], CRISP3 [137], S100A9 [138], RETN (resistin) [139], IL1RN [140], TLR4 [141], GGT1 [142], CTSD (cathepsin D) [143], FASLG (Fas ligand) [144], CCR4 [145], FCRL3 [146] and ABCF1 [147] were revealed and regarded as diagnostic biomarker in pancreatitis.…”

“…CHGA (chromogranin A) [48] and IL23R [49] [99], NRN1 [100], ABCA13 [101], CTSD (cathepsin D) [102], NCAM1 [103], SIGMAR1 [104], CNR2 [105], CCR4 [106], ABCB1 [107], TIMELESS (timeless circadian regulator) [108], IRF8 [109], TXNIP (thioredoxin interacting protein) [110], SUV39H1 [111], CRY1 [112], CRY2 [113], PDCD4 [114] and MGAT5 [115] played an important role in depression and anxiety. Accumulating evidence has demonstrated that MMP9 [116], S100A12 [117], HP (haptoglobin) [118], TLR5 [119], NRG1 [120], PLAU (plasminogen activator, urokinase) [121], SLC11A1 [122], AQP9 [123], CHIT1 [124], TLR4 [125], SLC26A8 [126], CTSD (cathepsin D) [127], SERPINB1 [128], FASLG (Fas ligand) [129], SLC4A4 [130], AQP3 [131] and IRF8 [132] appears to be constitutively associated with CF. MMP9 [133], S100A12 [134], SOCS3 [135], MMP8 [136], CRISP3 [137], S100A9 [138], RETN (resistin) [139], IL1RN [140], TLR4 [141], GGT1 [142], CTSD (cathepsin D) [143], FASLG (Fas ligand) [144], CCR4 [145], FCRL3 [146] and ABCF1 [147] were revealed and regarded as diagnostic biomarker in pancreatitis.…”