Interferon α/β Promotes Cell Survival by Activating Nuclear Factor κB through Phosphatidylinositol 3-Kinase and Akt

Yang, Chuan; Murti, Aruna; Pfeffer, Susan R.; Kim, Jong G.; Donner, David B.; Pfeffer, Lawrence M.

doi:10.1074/jbc.m011006200

Cited by 192 publications

(153 citation statements)

References 54 publications

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“…Several reports from other investigators also showed similar regulation between Akt and NF-κB pathways [60][61][62] and these results strongly suggest molecular cross-talk between NF-κB and Akt pathway and that 'dual' disruption of these pathways by genistein could be an effective strategy for the inhibition of cancer cells. Stoica et al, demonstrated that genistein exerted inhibitory effect on Akt activation induced by estradiol in MCF-7 cells [63;64].…”

Section: Effects On Regulation Of Akt Signaling Pathwaymentioning

confidence: 63%

Multi-targeted therapy of cancer by genistein

Banerjee¹,

Li²,

Wang³

et al. 2008

Cancer Letters

560

383

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Soy isoflavones have been identified as dietary components having an important role in reducing the incidence of breast and prostate cancers in Asian countries. Genistein, the predominant isoflavone found in soy products, has been shown to inhibit the carcinogenesis in animal models. There is a growing body of experimental evidence showing that the inhibition of human cancer cell growth by genisteinis mediated via the modulation of genes that are related to the control of cell cycle and apoptosis. It has been shown that genistein inhibits the activation of NF-κB and Akt signaling pathways, both of which are known to maintain a homeostatic balance between cell survival and apoptosis. Moreover, genistein antagonizes estrogen-and androgen-mediated signaling pathways in the processes of carcinogenesis. Furthermore, genistein has been found to have antioxidant properties, and shown to be a potent inhibitor of angiogenesis and metastasis. Taken together, both in vivo and in vitro studies have clearly shown that genistein, one of the major soy isoflavones, is a promising agent for cancer chemoprevention and further suggest that it could be an adjunct to cancer therapy by virtue of its effects on reversing radioresistance and chemoresistance. In this review, we attempt to provide evidence for these preventive and therapeutic effects of genistein in a succinct manner highlighting comprehensive state-of-the-art knowledge regarding its multi-targeted biological and molecular effects in cancer cells.

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Section: Effects On Regulation Of Akt Signaling Pathwaymentioning

confidence: 63%

Multi-targeted therapy of cancer by genistein

Banerjee¹,

Li²,

Wang³

et al. 2008

Cancer Letters

560

383

View full text Add to dashboard Cite

show abstract

“…Among the STAT proteins, STAT1 appears to play a key role in IFN-␣ signaling, 30 although STAT3 has also been implicated in mediating IFN-␣ activity in other studies. [31][32][33][34] Our study demonstrated that STAT3, not STAT1, was significantly activated by IFN-␣ at the concentrations (50 U or 100 U/mL) that show antiviral activity. The phosphorylated STAT1 did not respond to up to 100 U/mL IFN-␣ treatment, although it did so at 500 U/mL, a relatively higher concentration for antiviral effect in this model.…”

Section: Discussionmentioning

confidence: 90%

Gene Expression Associated With Interferon Alfa Antiviral Activity in An Hcv Replicon Cell Line

Zhu¹,

Zhao²,

Collins

et al. 2003

Hepatology

100

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“…NF-kB activation has been described in multiple systems but whether it protects cells or promotes apoptosis appears to depend on the cell type and method used to induce apoptosis (Chen et al, 2000;Gill and Windebank, 2000;Kuhnel et al, 2000;Yang et al, 2001; reviewed in Weaver et al, 2002). This varied response is undoubtedly related to the fact that NF-kB promotes the expression of both antiapoptotic and proapoptotic molecules.…”

Section: Discussionmentioning

confidence: 99%