Multi-targeted therapy of cancer by genistein

Abstract

Soy isoflavones have been identified as dietary components having an important role in reducing the incidence of breast and prostate cancers in Asian countries. Genistein, the predominant isoflavone found in soy products, has been shown to inhibit the carcinogenesis in animal models. There is a growing body of experimental evidence showing that the inhibition of human cancer cell growth by genisteinis mediated via the modulation of genes that are related to the control of cell cycle and apoptosis. It has been shown that genistein inhibits the activation of NF-κB and Akt signaling pathways, both of which are known to maintain a homeostatic balance between cell survival and apoptosis. Moreover, genistein antagonizes estrogen-and androgen-mediated signaling pathways in the processes of carcinogenesis. Furthermore, genistein has been found to have antioxidant properties, and shown to be a potent inhibitor of angiogenesis and metastasis. Taken together, both in vivo and in vitro studies have clearly shown that genistein, one of the major soy isoflavones, is a promising agent for cancer chemoprevention and further suggest that it could be an adjunct to cancer therapy by virtue of its effects on reversing radioresistance and chemoresistance. In this review, we attempt to provide evidence for these preventive and therapeutic effects of genistein in a succinct manner highlighting comprehensive state-of-the-art knowledge regarding its multi-targeted biological and molecular effects in cancer cells.

Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells

“…We found that HOTAIR and miR-141 expression are inversely correlated in renal carcinoma cells. Genistein has potent biological activity, regulates several signaling pathways in cancer cells, and promotes cancer cell death (29,30,50,51), and we have found that genistein regulates miRNAs (33,(52)(53)(54). We also found that genistein decreases HOTAIR expression while stimulating miR-141 expression, showing an inverse effect.…”

Flavonoid consumption and esophageal cancer among black and white men in the United States

“…7,8 The 2 flavonoid subclasses, anthocyanidins and isoflavonoids, that showed a protective effect in our study have various anticarcinogenic properties and are currently being tested in clinical trials. 20,21 Ref.…”

Protein-tyrosine Phosphatase 1B (PTP1B) Deficiency Confers Resistance to Transforming Growth Factor-β (TGF-β)-induced Suppressor Effects in Hepatocytes

“…Ϫ/Ϫ Hepatocytes-In addition to its direct effect on tyrosine kinases, several reports have related genisteinproapototic effects with NF-B pathway inhibition, which also can counteract TGF-␤ signaling (12,25). For this reason, we decided to investigate a possible implication of NF-B in our model.…”