Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells

Chiyomaru, Takeshi; Fukuhara, Shinichiro; Saini, Sharanjot; Majid, Shahana; Deng, Guoren; Shahryari, Varahram; Chang, Inik; Tanaka, Yuichiro; Enokida, Hideki; Nakagawa, Masayuki; Dahiya, Rajvir; Yamamura, Soichiro

doi:10.1074/jbc.m113.488593

Cited by 177 publications

(159 citation statements)

References 62 publications

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“…It was enough to demonstrate that the instability of this circular ncRNA was directly related to miRNA-671 [15]. Furthermore, the well-characterized lncRNA HOTAIR was reported to be repressed by miRNA-141 in the presence of the Ago2 complex in human cancer cells [45]. Another study also demonstrated that lncRNA HOTAIR was degraded jointly by HuR, miRNA-let7i and Ago2 [46], and lncRNA MALAT1 was testified to be downregulated by has-miR-125b during bladder cancer development [47].…”

Section: Post-transcriptional Regulation Of Lncrnasmentioning

confidence: 94%

Regulation of lncRNA expression

Liu

et al. 2014

Cellular and Molecular Biology Letters

184

122

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Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of lncRNAs. The transcription of non-coding RNA genes is regulated by many core transcription factors applied to protein-coding genes. However, specific DNA sequences may allow their unsynchronized transcription with their location-associated mRNAs. Additionally, there are multiple mechanisms involved in the post-transcriptional regulation of lncRNAs. Among these, microRNAs might have indispensible regulatory effects on lncRNAs, based on recent discoveries.

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Section: Post-transcriptional Regulation Of Lncrnasmentioning

confidence: 94%

Regulation of lncRNA expression

Liu

et al. 2014

Cellular and Molecular Biology Letters

184

122

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“…HOTAIR was reported to be induced by E 2 in MCF-7 BCa cells (Bhan, et al 2013), but others reported that E 2 -ERα directly that repressed HOTAIR in MCF-7 cells by binding to a genomic site 14.5 kB upstream of HOTAIR (Xue, et al 2016b). HOTAIR is downregulated by miR-141 (Chiyomaru, et al 2014) and is directly targeted by miR-34a in PCa cells (Chiyomaru, et al 2013). The 3' domain of HOTAIR binds lysine-specific demethylase 1 (LSD1)-CoREST and PRC2 interacts with a 5' domain.…”

Section: Examples Of Lncrnas Dysregulated In Endocrine-related Cancersmentioning

confidence: 99%

Non-coding RNAs: long non-coding RNAs and microRNAs in endocrine-related cancers

Klinge

2018

Endocrine-Related Cancer

100

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Abstract:The human genome is 'pervasively transcribed' leading to a complex array of noncoding RNAs (ncRNAs) that far outnumber coding mRNAs. ncRNAs have regulatory roles in transcription and post-transcriptional processes as well numerous cellular functions that remain to be fully described. Best characterized of the 'expanding universe' of ncRNAs are the ~ 22 nucleotide microRNAs (miRNAs) that base-pair to target mRNA's 3' untranslated region within the RNA-induced silencing complex (RISC) and block translation and may stimulate mRNA transcript degradation. Long non-coding RNAs (lncRNAs) are classified as >200 nucleotides in length, but range up to several kb and are heterogeneous in genomic origin and function.LncRNAs fold into structures that interact with DNA, RNA, and proteins to regulate chromatin dynamics, protein complex assembly, transcription, telomere biology, and splicing. Some lncRNAs act as sponges for miRNAs and decoys for proteins. Nuclear-encoded lncRNAs can be taken up by mitochondria and lncRNAs are transcribed from mtDNA. Both miRNAs and lncRNAs are dysregulated in endocrine cancers. This review provides an overview on the current understanding of the regulation and function of selected lncRNAs and miRNAs, and their interaction, in endocrine-related cancers: breast, prostate, endometrial, and thyroid.

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“…Owing to this function, HOTAIR overexpression in cancer leads to genome-wide changes in the chromatin-modifying complex binding sites. Interestingly, HOTAIR expression was recently reported to be inversely correlated with miR-141 expression in renal carcinoma cells (Chiyomaru et al, 2014). In essence, HOTAIR promotes malignancy, including proliferation and invasion, whereas miR-141 functions as a tumor suppressor.…”

Section: Intergenic Lncrnasmentioning

confidence: 99%

Noncoding RNAs and cancer

Akman¹,

Erson-Bensan

2014

Turk J Biol

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IntroductionFollowing the completion of the human genome a decade ago, we came across a surprisingly low number of proteincoding genes in the human genome compared to the initial predictions. The low number of protein-coding genes, corresponding to only 2% of the human genome, was surprising, because it meant that we were undervaluing the potential roles of alternative promoter usage, alternative splicing, alternative polyadenylation, and so on to explain the vast diversity of proteins in cells. It was also a realization that the rest of the genome must also have some role, either structural or functional. Indeed, over the years, studies have documented widespread transcription across 70%-90% of the genome with approximately 9000 small RNAs, 1100 microRNAs (miRNAs; http://microRNA.org), 32,000 long noncoding RNAs (lncRNAs), and 11,000 expressed pseudogenes (Bernstein et al., 2012;Volders et al., 2013). Based on increasing evidence, it has become clear that this nonprotein-coding portion of the genome is critical in managing the greater complexity of higher eukaryotes during development and in different physiological and/ or disease states, especially cancer. While most of the focus is on miRNAs as small noncoding RNAs, other long or small noncoding RNAs are attracting attention in normal and in cancer cells. Here we provide an overview of currently known noncoding RNA elements (Figure 1), their functions, and their connections with disease states, especially cancer (Table ). In the first part, lncRNAs and their subclasses will be discussed. The second part focuses on small noncoding RNAs. Long noncoding RNA classeslncRNAs are transcripts of longer than ~200 nucleotides with little or no protein-coding capacity (it is possible that some lncRNAs encode small peptides). In humans, with exceptions, lncRNAs are generally polyadenylated and are spliced to generate a small number of exonic regions (Derrien et al., 2012). On the other hand, evidence suggests some lncRNAs to be processed and stabilized by other mechanisms such as RNase P cleavage to generate a mature 3' end, capping by snoRNP complexes at both ends, or formation of circular structures (Zhang et al., 2013a).The lncRNA genes are positioned throughout various chromosomal regions of the genome. Therefore, the accepted classification of lncRNAs is generally based on their locations, whether they are intergenic, intronic, or found in the antisense strand [also known as natural antisense transcripts (NATs)] or upstream to annotated protein-coding genes. With the advancements of sequencing methods, along with other noncoding RNAs,

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Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells

Cited by 177 publications

References 62 publications

Regulation of lncRNA expression

Regulation of lncRNA expression

Non-coding RNAs: long non-coding RNAs and microRNAs in endocrine-related cancers

Noncoding RNAs and cancer

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