Interferon-γ-activated macrophages enhance angiogenesis from endothelial cells of rat aorta

Kobayashi, Shogo; Nagaura, Takeshi; Kimura, Ikuko; Kimura, Masayasu

doi:10.1016/0162-3109(94)90004-3

Cited by 17 publications

(7 citation statements)

References 29 publications

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“…Kobayashi et al 21 and Polverini et al 22 observed that monocytes and macrophages affect endothelial cell migration. We observed a correlation between the number of activated monocytes and macrophages associated with implants and endothelialization.…”

Section: Discussionmentioning

confidence: 97%

The effects of porosity on endothelialization of ePTFE implanted in subcutaneous and adipose tissue

Salzmann

Kleinert

Berman

et al. 1997

J. Biomed. Mater. Res.

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Healing of biomaterial implants varies depending on the type and structure of material and the tissue surrounding the implant. In this study we examined structural differences of 30 microm, 60 microm, and 100 microm expanded polytetrafluoroethylene (ePTFE) using scanning electron microscopy, and we also investigated differences in healing for these three different porosity ePTFE grafts implanted within subcutaneous tissue and adipose tissue. Scanning electron microscopic examination of 30 microm, 60 microm, and 100 microm ePTFE revealed structural differences and differences in fiber density within the internodal space. Circular patches (6 mm in diameter) of 30 microm ePTFE were implanted within subcutaneous tissue and epididymal fat pads of male Sprague-Dawley rats. After 5 weeks, the implants were removed and analyzed for fibrous capsule formation, endothelialization, and for activated monocytes and macrophages in association with the material. Histological evaluation revealed dense fibrous capsule formation surrounding only the 30 microm ePTFE subcutaneous implants. From immunohistochemistry data obtained, we generated an Endothelialization Index (measure of neovascularization) and a Monocyte/Macrophage Index (measure of inflammatory response) for each sample. Consistently, 60 microm ePTFE had the greatest Endothelialization Index at both implant sites while 100 microm ePTFE generally had the largest values for the Monocyte/Macrophage Index. These data indicate that both the structure of the material and the site of implant influence the healing characteristics of ePTFE and suggest that activated monocytes and/or macrophages associated with the implant may inhibit endothelialization of ePTFE.

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Section: Discussionmentioning

confidence: 97%

The effects of porosity on endothelialization of ePTFE implanted in subcutaneous and adipose tissue

Salzmann

Kleinert

Berman

et al. 1997

J. Biomed. Mater. Res.

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“…Macrophages activated by IFN-g enhance angiogenesis in cultures of endothelial cells taken from rat aorta [19]. A growing body of evidence demonstrates the important role of heme oxygenase-1 (HO-1) in the stimulation of angiogenesis [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

“…A growing body of evidence demonstrates the important role of heme oxygenase-1 (HO-1) in the stimulation of angiogenesis [20][21][22]. In human melanomas [23] and gliomas [24], HO-1 may be a useful marker for macrophage infiltration as well as neovascularization [19].…”

Section: Introductionmentioning

confidence: 99%

Action of prolactin, IFN-γ, TNF-α and LPS on heme oxygenase-1 expression and VEGF release in human monocytes/macrophages

Malaguarnera

Imbesi

Rosa

et al. 2005

International Immunopharmacology

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“…10 Interferon‐γ‐activate macrophages also enhanced angiogenesis in cultured endothelial cells and rat aorta. 11 Thus, the angiogenic activity of macrophages is related to their secretory activity and macrophages are not angiogenic per se but appear to require stimulation. Leek et al demonstrated a direct correlation between neovascularization and a focal increase in macrophage infiltration in human breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of tumor‐associated macrophage count in human bladder cancer

Hanada¹,

Nakagawa

Emoto³

et al. 2000

Int J of Urology

252

184

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Background: We determined the tumor-associated macrophage (TAM) count to investigate its importance in predicting clinical outcome or prognosis in patients with bladder cancer. Methods:The TAM count and microvessel count (MVC) were determined immunohistochemically in 63 patients with bladder cancer, including 40 superficial bladder cancers and 23 invasive bladder cancers. To examine the relationship between TAM count and clinical outcome or prognosis in bladder cancer, cystectomy rates, distant metastasis rates, vascular invasion rates and 5 year survival rates were compared between patients with low (< 67) and high (≥ 67) TAM counts. Results:The TAM count in invasive bladder cancers (154.22 ± 11.98) was significantly higher than in superficial bladder cancers (49.05 ± 7.76; P < 0.0001). The MVC in invasive bladder cancers (71.55 ± 10.44) was also significantly higher than in superficial bladder cancers (47.02 ± 5.57; P < 0.05). There was a positive correlation between TAM count and MVC (r = 0.30; P = 0.02).Immunohistochemical staining using CD68/horseradish peroxidase monoclonal antibody showed more infiltrating cells in invasive than superficial bladder cancers. Patients with a high TAM count (≥ 67) showed significantly higher rates of cystectomy, distant metastasis and vascular invasion than those with a lower TAM count (< 67). The 5 year survival rate estimated using the KaplanMeier method was significantly lower in patients with a high TAM count than in those with a low TAM count (P < 0.0001). Conclusions:Our results suggest that determination of TAM count in bladder cancer tissues is of value to predict the clinical outcome or prognosis and to select appropriate treatment strategies in patients with bladder cancer.

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Interferon-γ-activated macrophages enhance angiogenesis from endothelial cells of rat aorta

Cited by 17 publications

References 29 publications

The effects of porosity on endothelialization of ePTFE implanted in subcutaneous and adipose tissue

The effects of porosity on endothelialization of ePTFE implanted in subcutaneous and adipose tissue

Action of prolactin, IFN-γ, TNF-α and LPS on heme oxygenase-1 expression and VEGF release in human monocytes/macrophages

Prognostic value of tumor‐associated macrophage count in human bladder cancer

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