Interferon-γ and Colorectal Cancer: an up-to date

Kosmidis, Christoforos; Sapalidis, Konstantinos; Κoletsa, Triantafyllia; Kosmidou, Maria; Efthimiadis, Christoforos; Anthimidis, Georgios; Varsamis, Nikolaos; Michalopoulos, Nikolaos; Koulouris, Charilaos; Atmatzidis, Stefanos; Liavas, Lazaros; Strati, Titika-Marina; Koimtzis, Georgios; Tsakalidis, Alexandros; Mantalovas, Stylianos; Zarampouka, Katerina; Florou, Maria; Giannakidis, Dimitrios; Georgakoudi, Eleni; Baka, Sofia; Man, Yan-Gao; Kesisoglou, Isaac

doi:10.7150/jca.22962

Cited by 27 publications

(22 citation statements)

References 64 publications

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“…For immune cells, IFNγ signaling activates antigen‐presenting cells (APCs) to upregulate the expressions of cytokines (IL‐12 and IL‐18) and costimulatory molecule CD86 that enhance Th1 differentiation and cytotoxic T lymphocyte (CTL) function . Furthermore, those APCs activated by IFNγ increase the expression of MHC molecules and components of the antigen‐processing machinery.…”

Section: The Role Of Ifnγ In Immune Eliminationmentioning

confidence: 99%

“…For immune cells, IFNγ signaling activates antigenpresenting cells (APCs) to upregulate the expressions of cytokines (IL-12 and IL-18) and costimulatory molecule CD86 that enhance Th1 differentiation and cytotoxic T lymphocyte (CTL) function. [26][27][28] Furthermore, those APCs activated by IFNγ increase the expression of MHC molecules and components of the antigen-processing machinery. In addition, IFNγ induces a number of signals in T cells to enable T cell function effectively, while the loss of IFNγ signaling pathways in T cells dampens T cell responses and allows tumor growth and persistence.…”

Section: Immune Eliminationmentioning

confidence: 99%

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Interferon gamma in cancer immunotherapy

2018

Cancer Medicine

285

181

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Immune system can recognize self vs transformed self. That is why cancer immunotherapy achieves notable benefits in a wide variety of cancers. Recently, several papers reported that immune checkpoint blockade therapy led to upregulation of IFNγ and in turn clearance of tumor cells. In this review, we conducted an extensive literature search of recent 5‐year studies about the roles of IFNγ signaling in both tumor immune surveillance and immune evasion. In addition to well‐known functions, IFNγ signaling also induces tumor ischemia and homeostasis program, resulting in tumor clearance and tumor escape, respectively. The yin and the yang of IFNγ signaling are summarized. Thus, this review helps us to comprehensively understand the roles of IFNγ in tumor immunity, which contributes to better design and management of clinical immunotherapy approaches.

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Section: The Role Of Ifnγ In Immune Eliminationmentioning

confidence: 99%

Section: Immune Eliminationmentioning

confidence: 99%

Interferon gamma in cancer immunotherapy

2018

Cancer Medicine

285

181

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“…It is a cytokine produced by natural killer cells, natural killer T cells, antigen-specific CD4 Th1 and CD8 cytotoxic effector lymphocytes, non-cytotoxic innate lymphoid cells, and mucosal epithelial cells. IFN-γ induces class I and II major histocompatibility complex expression on antigen-presenting cells, promotes natural killer activity, increases antigen presentation and lysosome activity of macrophages, activates inducible nitric oxide synthase, induces production of IgG by plasma cells, promotes adhesion required for leukocyte migration, and has direct antiviral effect (by induction of tripartite motif-containing protein 5 and apolipoprotein B-mRNA editing enzyme, among others) [69]. IFN-γ levels correlate with good prognosis of patients with different types of cancer [69,70].…”

Section: Interferon Gamma (Ifn-γ)mentioning

confidence: 99%

“…IFN-γ induces class I and II major histocompatibility complex expression on antigen-presenting cells, promotes natural killer activity, increases antigen presentation and lysosome activity of macrophages, activates inducible nitric oxide synthase, induces production of IgG by plasma cells, promotes adhesion required for leukocyte migration, and has direct antiviral effect (by induction of tripartite motif-containing protein 5 and apolipoprotein B-mRNA editing enzyme, among others) [69]. IFN-γ levels correlate with good prognosis of patients with different types of cancer [69,70]. IFN-γ levels can be measured in the tumor tissue or tumor tissue supernatant with the following techniques: flow cytometry, ELISA, and RT-PCR.…”

Section: Interferon Gamma (Ifn-γ)mentioning

confidence: 99%

Air Pouch Model: An Alternative Method for Cancer Drug Discovery

Franco‐Molina¹,

Santana-Krímskaya²,

Rodríguez‐Padilla³

2019

Cell Culture

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The tumor microenvironment (TME) is composed of cancer, immune, and stromal cells that interact through cell-to-cell contact and a diverse milieu of cytokines, chemokines, growth factors, and proteases. Several reports have linked the presence of specific cell subtypes with tumor stages, prognosis, and patient survival. Understanding cancer cell behavior and their response to treatment within the tumor microenvironment is essential to prevent establishment, growth, and progression of tumors. Many synthetic and biological agents have been tested using cell-based assays, which do not provide reliable predictive capacity for drug candidate performance in vivo. In this chapter, we discuss about the benefits of an air pouch tumor model, in which tumor cells are inoculated inside an air pouch created on the back of the mouse. The air pouch cancer model serves as a confined/localized tumor microenvironment, where direct contact of drug candidates and tumor cells is guaranteed in a tumor microenvironment context. Therefore, the efficacy of the therapeutic agent can be accurately assessed in vivo.

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“…IFN-γ having been clinically used to treat various malignant tumors is a cytokine related to cytostatic/cytotoxic and antitumor when the immune response is adaptive to a cell [15]. Moreover, it is the main activator of macrophages [8]. The macrophage is a type of phagocytes that function to detect and destroy pathogens (microorganisms or viruses) and apoptotic cells [10].…”

Section: Introductionmentioning

confidence: 99%

A tumor growth model with chemotherapy and diffusion effect

Tamsih¹,

Trisilowati²,

Habibah³

2020

J. Math. Computer Sci.

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Chemotherapy is the most common treatment for cancer by using certain drugs or hormones. One of the mechanisms to transport the drugs within the human body is called diffusion-passive transport where the substances move from an area of high concentration to an area of low concentration. By adding chemotherapy and the diffusion effect, a model of tumor growth and its interaction with some types of immune cell such as macrophages, CD8+T and IFN-γ is studied. Regarding to the analysis result, the existence of tumor equilibrium point is determined by Cardan's condition. It is locally asymptotically stable if it satisfies the Routh-Hurwitz criterion. Furthermore, the simulation shows that we can eliminate more tumor cell by extending the duration of chemotherapy injection and shortening the interval of chemotherapy. However, these methods are not effective in the long term. It is also observed that the value of the diffusion coefficient affects the growth of the tumor and other cells.

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Interferon-γ and Colorectal Cancer: an up-to date

Cited by 27 publications

References 64 publications

Interferon gamma in cancer immunotherapy

Interferon gamma in cancer immunotherapy

Air Pouch Model: An Alternative Method for Cancer Drug Discovery

A tumor growth model with chemotherapy and diffusion effect

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