Interferon-γ/CCR5 expression in invariant natural killer T cells and CCL5 expression in capillary veins of dermal papillae correlate with development of psoriasis vulgaris

Kono, Fumihiko; Honda, Tetsuya; Aini, Wulamujiang; Manabe, Toshiaki; Haga, Hironori; Tsuruyama, Tatsuaki

doi:10.1111/bjd.12812

Cited by 19 publications

(13 citation statements)

References 31 publications

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“…Several of them have been identified to be associated with the incidence and development of psoriasis. Kono et al (18) reported that the expression of CCR5 and CCL5 was associated with the development of psoriasiform hyperplasia and microabscess. Also, through managing multiple chemokines, keratinocytes actively participate in the inflammatory response in psoriasis patients (19).…”

Section: Discussionmentioning

confidence: 99%

Identification of key pathways and genes in psoriasis via gene microarray analysis

et al. 2016

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Abstract. Psoriasis is a common chronic inflammatory, immune-mediated skin disease with a high incidence worldwide. It is a multifactorial disease and its exact pathogenesis has remained largely elusive. The purpose of the present study was to uncover the key pathways and genes associated with the incidence of psoriasis. Gene expression profiles (dataset no. GSE13355) were downloaded from Gene Expression Omnibus. Differentially expressed genes between skin samples from patients with lesional psoriasis or non-lesional psoriasis and those of normal healthy controls were identified using Bioconductor version 2.13 based in R. Kyoto Encyclopedia of Genes and genomes (KEGG) pathways significantly enriched in patients with lesional psoriasis were identified using gene set enrichment analysis (GSEA). Key KEGG pathways were then identified using leading-edge analysis of the results of GSEA. Differentially expressed genes involved in the significantly enriched KEGG pathways were considered as key genes. Several KEGG pathways which are known to be associated with lesional psoriasis, including autoimmune thyroid disease signaling, natural killer cell-mediated cytotoxicity signaling, as well as several novel pathways, including FCγR-mediated phagocytosis and neurotrophin signaling pathway, were identified. Several verified and novel genes were also got. The present study revealed key pathways and genes associated with psoriasis, which may serve as important biomarkers for the diagnosis and treatment of psoriasis.

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Section: Discussionmentioning

confidence: 99%

Identification of key pathways and genes in psoriasis via gene microarray analysis

et al. 2016

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“…Th1 immune response is another possible pathway in the triggering of plaque psoriasis. IL-12 is a potent inducer of the Th1 differentiation with naïve lymphocytes becoming IFN-γ-producing cells [ 25 , 26 ]. Our results showed that imiquimod did not increase IL-12 and IFN-γ in mouse skin.…”

Section: Discussionmentioning

confidence: 99%

Using Imiquimod-Induced Psoriasis-Like Skin as a Model to Measure the Skin Penetration of Anti-Psoriatic Drugs

et al. 2015

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ObjectivePsoriasis is a chronic inflammatory skin disease and topical therapy remains a key role for treatment. The aim of this study is to evaluate the influence of psoriasis-like lesions on the cutaneous permeation of anti-psoriatic drugs.MethodsWe first set up imiquimod-induced dermatitis in mice that closely resembles human psoriasis lesions. The development of the lesions is based on the IL-23/IL17A axis for phenotypical and histological characteristics. Four drugs, 5-aminolevulinic acid (ALA), tacrolimus, calcipotriol, and retinoic acid, were used to evaluate percutaneous absorption.ResultsThe most hydrophilic molecule, ALA, revealed the greatest enhancement on skin absorption after imiquimod treatment. Imiquimod increased the skin deposition and flux of ALA by 5.6 to 14.4-fold, respectively, compared to normal skin. The follicular accumulation of ALA was also increased 3.8-fold. The extremely lipophilic drug retinoic acid showed a 1.7- and 3.8-fold increase in skin deposition and flux, respectively. Tacrolimus flux was enhanced from 2 to 21 μg/cm2/h by imiquimod intervention. However, imiquimod did not promote skin deposition of this macrolide. The lipophilicity, but not the molecular size, dominated drug permeation enhancement by psoriatic lesions. The in vivo percutaneous absorption of ALA and rhodamine B examined by confocal microscopy confirmed the deficient resistance of epidermal barrier for facilitating cutaneous delivery of drugs via psoriasis-like skin.ConclusionWe established the topical delivery profiles of anti-psoriatic drugs via imiquimod-treated psoriasis-like skin.

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“…iNKT cells have been implicated as playing roles in infection control [11,12], inflammatory bowel diseases [13], abortion [14], transplantation tolerance [15,16], suppression of autoimmune diseases [17][18][19][20], psoriasis and atopic dermatitis [21], and the regulation of allergic disorders [22,23]. iNKT cells have the potential to activate or suppresses immune system by release of variable cytokines including IFN-γ, IL-4, IL-10, and IL-17.…”

Section: Invariant Natural Killer T (Inkt) Cells In Diseasesmentioning

confidence: 99%

“…where the perimeter (P) of individual cells was divided by the circumference of a circle with the same area (A), with the real circle factor being equivalent to 1.0. As the boundary of a binary image is composed of discrete pixels, IMAQ Vision (National Instruments Corporation, Austin, TX, USA) was used to sub-sample the boundary [21,39]. The scheme of quantitative morphometry is shown below.…”

Section: Quantitative Morphometrymentioning

confidence: 99%

The Roles of Invariant NKT Cells in Bowel Immunity — Suppression of Tumor Progression and Rejection of Intestinal Transplants

Tsuruyama¹,

Aini²

2014

Immune Response Activation

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Interferon-γ/CCR5 expression in invariant natural killer T cells and CCL5 expression in capillary veins of dermal papillae correlate with development of psoriasis vulgaris

Abstract: IFN-γ/CCR5 expression in iNKT cells and CCL5 expression in vessels of dermal papillae correlate with the development of psoriasiform hyperplasia and microabscess. We propose that these iNKT cells may become useful targets for development of novel therapeutic approaches to PV.

Cited by 19 publications

References 31 publications

Identification of key pathways and genes in psoriasis via gene microarray analysis

Identification of key pathways and genes in psoriasis via gene microarray analysis

Using Imiquimod-Induced Psoriasis-Like Skin as a Model to Measure the Skin Penetration of Anti-Psoriatic Drugs

The Roles of Invariant NKT Cells in Bowel Immunity — Suppression of Tumor Progression and Rejection of Intestinal Transplants

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