Interferon-τ upregulates prolactin receptor mRNA in the ovine endometrium during the peri-implantation period

Martin, Cyril; Pessemesse, Laurence; Llosa-Hermier, M.P. de la; Martal, J.; Djiane, Jean; Charlier, Madia

doi:10.1530/rep.1.00158

Cited by 17 publications

(12 citation statements)

References 30 publications

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“…However, intrauterine infusions of CSH1 further increases endometrial SPP1, STC1, and UTMP gene expression, but only when ewes receive progesterone and intrauterine infusions of IFNT (Spencer et al 1999b, Noel et al 2003. The effects of IFNT may be attributed, in part, to increasing PRLR in the endometrial glands (Martin et al 2004). Available evidence indicates that placental hormones play key roles in stimulating endometrial gland morphogenesis and differentiated functions during pregnancy that are required for conceptus development in ruminants.…”

Section: Csh1 Regulation Of Uterine Gland Morphogenesis and Secretorymentioning

confidence: 99%

Genes involved in conceptus–endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches

Spencer¹,

Sandra²,

Wolf³

2008

Reproduction

274

253

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This review summarizes new knowledge on expression of genes and provides insights into approaches for study of conceptus-endometrial interactions in ruminants with emphasis on the peri-implantation stage of pregnancy. Conceptus-endometrial interactions in ruminants are complex and involve carefully orchestrated temporal and spatial alterations in gene expression regulated by hormones from the ovary and conceptus. Progesterone is the hormone of pregnancy and acts on the uterus to stimulate blastocyst survival, growth, and development. Inadequate progesterone levels or a delayed rise in progesterone is associated with pregnancy loss. The mononuclear trophectoderm cells of the elongating blastocyst synthesize and secrete interferon-t (IFNT), the pregnancy recognition signal. Trophoblast giant binucleate cells begin to differentiate and produce hormones including chorionic somatomammotropin 1 (CSH1 or placental lactogen). A number of genes, induced or stimulated by progesterone, IFNT, and/or CSH1 in a cell-specific manner, are implicated in trophectoderm adhesion to the endometrial luminal epithelium and regulation of conceptus growth and differentiation. Transcriptional profiling experiments are beginning to unravel the complex dynamics of conceptus-endometrial interactions in cattle and sheep. Future experiments should incorporate physiological models of pregnancy loss and be complemented by metabolomic studies of uterine lumen contents to more completely define factors required for blastocyst survival, growth, and implantation. Both reduction and holistic approaches will be important to understand the multifactorial phenomenon of recurrent pregnancy loss and provide a basis for new strategies to improve pregnancy outcome and reproductive efficiency in cattle and other domestic animals.

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Section: Csh1 Regulation Of Uterine Gland Morphogenesis and Secretorymentioning

confidence: 99%

Genes involved in conceptus–endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches

Spencer¹,

Sandra²,

Wolf³

2008

Reproduction

274

253

View full text Add to dashboard Cite

show abstract

“…However, intrauterine infusions of CSH1 further increases SPP1, STC1, and UTMP gene expression in the ovine uterus, but only when ewes receive P4 and intrauterine infusions of IFNT (200,202). The effects of IFNT may be attributed, in part, to increasing PRLR in the endometrial glands (203). Available evidence indicates that placental hormones play key roles in stimulating endometrial gland morphogenesis and differentiated functions during pregnancy that are required for conceptus development in ruminants.…”

Section: Servomechanisms Regulating Uterine Gland Morphogenesis and Smentioning

confidence: 99%

Uterine receptivity to implantation of blastocysts in mammals

Bazer¹,

Spencer²,

Johnson³

et al. 2011

Front Biosci

136

115

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Reproduction in mammals is a highly complex biological process. The critical importance of reproduction to propagation of species required the natural evolution of various strategies that vary considerably across species. Regardless of species, a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus must be established during the peri-implantation period. The uterus must provide a microenvironment that supports growth and development of the conceptus and is receptive to implantation. During the same period, the conceptus must provide its pregnancy recognition signaling to sustain the functional life of corpora lutea for production of progesterone which is essential for implantation and placentation; critical events for successful pregnancy. However, it is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or to the failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. The challenge is to understand the complexity of key mechanisms that are characteristic of successful reproduction in humans and animals and to use that knowledge to enhance fertility and reproductive health or to establish acceptable methods for control of fertility.

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“…Indeed, PRLRs are expressed exclusively in the endometrial glands of the ovine uterus, and PL binds to those receptors [35,38,58]. Furthermore, IFNT stimulates PRLRs in the endometrial glands of the ovine uterus [59]. Although likely more complicated, available evidence supports the idea that progesterone downregulates PGR, which is permissive for the onset of STC1, and then IFNT stimulates PRLRs, which in turn respond to PL from the new trophoblast giant binucleate cells, which further stimulate STC1 gene expression along with GH during later pregnancy.…”

Section: Stc1 In the Ovine Uterusmentioning

confidence: 99%

Stanniocalcin (STC) in the Endometrial Glands of the Ovine Uterus: Regulation by Progesterone and Placental Hormones1

Song

Bazer

Wagner

et al. 2006

Biology of Reproduction

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Stanniocalcin (STC) is a hormone in fish that regulates calcium levels. Mammals have two orthologs of STC with roles in calcium and phosphate metabolism and perhaps cell differentiation. In the kidney and gut, STC regulates calcium and phosphate homeostasis. In the mouse uterus, Stc1 increases in the mesometrial decidua during implantation. These studies determined the effects of pregnancy and related hormones on STC expression in the ovine uterus. In Days 10-16 cyclic and pregnant ewes, STC1 mRNA was not detected in the uterus. Intriguingly, STC1 mRNA appeared on Day 18 of pregnancy, specifically in the endometrial glands, increased from Day 18 to Day 80, and remained abundant to Day 120 of gestation. STC1 mRNA was not detected in the placenta, whereas STC2 mRNA was detected at low abundance in conceptus trophectoderm and endometrial glands during later pregnancy. Immunoreactive STC1 protein was detected predominantly in the endometrial glands after Day 16 of pregnancy and in areolae that transport uterine gland secretions across the placenta. In ovariectomized ewes, long-term progesterone therapy induced STC1 mRNA. Although interferon tau had no effect on endometrial STC1, intrauterine infusions of ovine placental lactogen (PL) increased endometrial gland STC1 mRNA abundance in progestinized ewes. These studies demonstrate that STC1 is induced by progesterone and increased by a placental hormone (PL) in endometrial glands of the ovine uterus during conceptus (embryo/fetus and extraembryonic membranes) implantation and placentation. Western blot analyses revealed the presence of a 25-kDa STC1 protein in the endometrium, uterine luminal fluid, and allantoic fluid. The data suggest that STC1 secreted by the endometrial glands is transported into the fetal circulation and allantoic fluid, where it is hypothesized to regulate growth and differentiation of the fetus and placenta, by placental areolae.

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Interferon-τ upregulates prolactin receptor mRNA in the ovine endometrium during the peri-implantation period

Cited by 17 publications

References 30 publications

Genes involved in conceptus–endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches

Genes involved in conceptus–endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches

Uterine receptivity to implantation of blastocysts in mammals

Stanniocalcin (STC) in the Endometrial Glands of the Ovine Uterus: Regulation by Progesterone and Placental Hormones1

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