Interferoninduzierte paranoide PsychoseLiteraturübersicht und Kasuistik

Abstract

Adverse neuropsychiatric effects under interferon treatment have often been reported. However, the pathogenetic mechanisms have not yet been fully explored. Most frequent are affective disorders, but psychotic decompensations can also occur, as reported in the following case. Thus, taking a detailed psychiatric history is required before starting a therapy with interferon, since past and current psychiatric disorders might imply an increased risk for psychiatric adverse effects.

Persistent interferon‐β‐1b‐induced psychosis in a patient with multiple sclerosis

“…It is less likely to be associated with other psychiatric symptoms than IFN‐α and is extremely rarely associated with psychosis. The reason for differences in psychiatric symptoms and psychosis‐inducing potential between IFN‐α and IFN‐β is unclear 1 …”