Intergenerational associations of adverse birth outcomes: A surveillance report

Liu, Dong; Lin, Ge; Su, Dejun; Alexender, James M.; Sun, Xiaobin; Qu, Ming

doi:10.1016/j.pmedr.2020.101226

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…In case they did not respond to the email or did not provide the necessary data, we excluded the meta-analysis study (n=12). Thus, 20 studies were included in the meta-analysis, 14 in the mean difference analysis (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) and 11 in the Odds Ratio (3,8,15,18,23,(26)(27)(28)(29)(30)(31) .Table 1 shows a description of the studies included in the meta-analysis.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Thus, twenty studies were included in the meta-analysis, fourteen in the MD analysis (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) and eleven in the OR (3,8,15,18,23,(26)(27)(28)(29)(30)(31) .Table 1 shows a description of the studies included in the meta-analysis.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The results of the literature quality evaluation are shown in Table 3. Of the twenty studies included in this review, seventeen studies met more than half of the methodological quality criteria score (3,(14)(15)(16)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) . Furthermore, three studies had four points in methodological quality (8,17,23) .…”

Section: Quality Assessmentmentioning

confidence: 99%

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Intergenerational transmission of birth weight: a systematic review and meta-analysis

et al. 2022

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The objectives of this study were (1) to systematically review the literature on the association between birth weight in children born in the first and second generation; (2) to quantify this association by performing a meta-analysis. A systematic review was carried in six databases (Pubmed, Science Direct, Web of Science, Embase, Scopus, CINAHL and LILACS), in January 2021, for studies that recorded the birth weight of parents and children. A meta-analysis using random effects to obtain a pooled effect of the difference in birth weight and the association of low birth weight (LBW) between generations was performed. Furthermore, univariable meta-regression was conducted to assess heterogeneity. Egger’s tests were used to possible publication biases. Of the 9878 identified studies, 70 were read in full and 20 were included in the meta-analysis (10 prospective cohorts and 10 retrospective cohorts), 14 studies for difference in means and 11 studies for the association of LBW between generations (23 estimates). Across all studies, there was no statistically significant mean difference (MD) birth weight between first and second-generation (MD 19.26, 95% CI -28.85, 67.36; p= 0.43). Overall, children of LBW parents were 69% more likely to have low birth weight (pooled effect size (ES) 1.69, 95% CI 1.46, 1.95); I 2 : 85,8%). No source of heterogeneity was identified among the studies and no publication bias. The average birth weight of parents does not influence the average birth weight of children, however the proportion of LBW among the parents seems to affect the offspring’s birth weight.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

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Intergenerational transmission of birth weight: a systematic review and meta-analysis

et al. 2022

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“…No association between grandparental smoking and adolescent BMI Naess [ 69 ] Norway Birthweight Death certificates for ICD: breast cancer, chronic obstructive pulmonary disease, cardiovascular causes, coronary heart disease, stroke, diabetes, lung cancer Identified children (F2) births from 1967–2009 and linked parents (Maternal and Paternal) (F1) and grandparents (Maternal and Paternal) (F0); Grandparents who died of cardiovascular causes associated with lower likelihood of higher birthweight; much of this was due to maternal smoking in pregnancy. U-shaped associations were seen with grandchild birthweight and maternal grandmother mortality from diabetes; inverse associations for all other grandparents Nebraska Mother Index [ 125 ] USA Birthweight, gestational age, delivery type Linked vital statistics New Jersey [ 126 ] USA PTB Education, marital status Linked vital statistics Grandmother’s education predicted PTB for grandchildren Norwegian Mother and Child Birth Cohort (MoBa) [ 127 ] Norway Birthweight, gestational age, birth defects Health, medication, smoking Primarily a birth cohort with child follow-up, but linked to other registries for some analyses Pathways to Adulthood [ 128 , 129 ] Baltimore, USA Birthweight Smoking, health, BMI, income Follow-up of the Collaborative Perinatal Project birth cohort; includes interviews and medical records Higher F0 income/needs ratio associated with higher birthweight. Higher F0 education associated with higher birthweight only if F1 education was lower.…”

Section: Multigenerational Effectsmentioning

confidence: 99%

The Impact of Early-Life Exposures on Women’s Reproductive Health in Adulthood

2021

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Purpose of Review To review the effects of early-life, preconception, and prior-generation exposures on reproductive health in women. Recent Findings Women’s early-life factors can affect reproductive health by contributing to health status or exposure level on entering pregnancy. Alternately, they can have permanent effects, regardless of later-life experience. Nutrition, social class, parental smoking, other adverse childhood experiences, environmental pollutants, infectious agents, and racism and discrimination all affect reproductive health, even if experienced in childhood or in utero. Possible transgenerational effects are now being investigated through three- or more-generation studies. These effects occur with mechanisms that may include direct exposure, behavioral, endocrine, inflammatory, and epigenetic pathways. Summary Pregnancy is increasingly understood in a life course perspective, but rigorously testing hypotheses on early-life effects is still difficult. In order to improve the health outcomes of all women, we need to expand our toolkit of methods and theory. Supplementary Information The online version contains supplementary material available at 10.1007/s40471-021-00279-0.

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“…26 27 Some studies indicate no differences in hormonal status or pubertal development in female offspring conceived by ART, yet some studies report differences in hormonal status and sperm quality among male offspring conceived by ART, but results are conflicting. [28][29][30][31][32][33][34] Finally, some adverse pregnancy outcomes recur from mother to daughter [35][36][37][38][39][40][41][42] or son; 36 39 41 although whether this recurrence is also present in those conceived by ART is unknown. To the best of our knowledge, no studies have examined pregnancy outcomes or fertility rates in people who were conceived using ART and their naturally conceived peers.…”

Section: Introductionmentioning

confidence: 99%

Reproductive outcomes in women and men conceived by assisted reproductive technologies in Norway: prospective registry based study

Carlsen

Wilcox

Magnus

et al. 2023

bmjmed

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ObjectivesTo determine whether the perinatal outcomes of women or men who were conceived by assisted reproductive technologies are different compared with their peers who were naturally conceived.DesignProspective registry based study.SettingMedical Birth Registry of Norway.ParticipantsPeople born in Norway between 1984 and 2002 with a registered pregnancy by the end of 2021.ExposurePeople who were conceived by assisted reproductive technologies and have had a registered pregnancy.Main outcome measuresComparing pregnancies and births of people who were conceived by assisted reproductive technologies and people who were naturally conceived, we assessed mean birth weight, gestational age, and placental weight by linear regression, additionally, the odds of congenital malformations, a low 5 min Apgar score (<7), transfer to a neonatal intensive care unit, delivery by caesarean section, use of assisted reproductive technologies, hypertensive disorders of pregnancy and pre-eclampsia, preterm birth, and offspring sex, by logistic regression. The occurrence of any registered pregnancy from people aged 14 years until age at the end of follow-up was assessed using Cox proportional regression for both groups.ResultsAmong 1 092 151 people born in Norway from 1984 to 2002, 180 652 were registered at least once as mothers, and 137 530 as fathers. Of these, 399 men and 553 women were conceived by assisted reproductive technologies. People who were conceived by assisted reproductive technologies had little evidence of increased risk of adverse outcomes in their own pregnancies, increased use of assisted reproductive technologies, or any difference in mean birth weight, placental weight, or gestational age. The only exception was for an increased risk of the neonate having a low Apgar score at 5 min (adjusted odds ratio 1.86 (95% confidence interval 1.20 to 2.89)) among women who were conceived by assisted reproductive technologies. Odds were slightly decreased of having a boy among mothers conceived by assisted reproductive technologies (odds ratio 0.79 (95% confidence interval 0.67 to 0.93)). People conceived by assisted reproductive technologies were slightly less likely to have a registered pregnancy within the follow-up period (women, adjusted hazard ratio 0.88 (95% CI 0.81 to 0.96); men, 0.91 (0.83 to 1.01)).ConclusionsPeople conceived by assisted reproductive technologies were not at increased risk of obstetric or perinatal complications when becoming parents. The proportion of people conceived by assisted reproductive technologies with a registered pregnancy was lower than among people who were naturally conceived, but a longer follow-up is required to fully assess their fertility and reproductive history.

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Intergenerational associations of adverse birth outcomes: A surveillance report

Abstract: Highlights A statewide assessment of intergenerational adverse birth outcomes in terms of preterm birth and low birth weight. Associating both mother and her siblings' birth records to the adverse birth outcomes. Found significant intergenerational associations of adverse birth outcomes.

Cited by 7 publications

References 25 publications

Intergenerational transmission of birth weight: a systematic review and meta-analysis

Intergenerational transmission of birth weight: a systematic review and meta-analysis

The Impact of Early-Life Exposures on Women’s Reproductive Health in Adulthood

Reproductive outcomes in women and men conceived by assisted reproductive technologies in Norway: prospective registry based study

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