Intergenerational transmission of maternal care deficiency and offspring development delay induced by perinatal protein malnutrition

Gianatiempo, Octavio; Sonzogni, Silvina V.; Fesser, Estefanía A.; Belluscio, Laura María; Smucler, Ezequiel; Sued, Mariela; Cánepa, Eduardo T.

doi:10.1080/1028415x.2018.1509178

Cited by 12 publications

(4 citation statements)

References 51 publications

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“…Undernutrition in utero induces abnormal methylation in F1 sperm [ 14 , 20 ]. Furthermore, the offspring exposed to malnutrition in utero are prone to onset of chronic diseases, such as obesity, diabetes, and cardiovascular disease [ 29 , 30 ]. Martinez et al reported that methylation changes in offspring sperm may play a role for the intergenerational transmission of metabolic disorders [ 14 ], whereas the altered methylation in offspring sperm is not maintained in the late-gestational somatic tissues of F2 [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Inheritance of perturbed methylation and metabolism caused by uterine malnutrition via oocytes

et al. 2023

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Background Undernourishment in utero has deleterious effects on the metabolism of offspring, but the mechanism of the transgenerational transmission of metabolic disorders is not well known. In the present study, we found that undernourishment in utero resulted in metabolic disorders of female F1 and F2 in mouse model. Results Undernutrition in utero induced metabolic disorders of F1 females, which was transmitted to F2 females. The global methylation in oocytes of F1 exposed to undernutrition in utero was decreased compared with the control. KEGG analysis showed that genes with differential methylation regions (DMRs) in promoters were significantly enriched in metabolic pathways. The altered methylation of some DMRs in F1 oocytes located at the promoters of metabolic-related genes were partially observed in F2 tissues, and the expressions of these genes were also changed. Meanwhile, the abnormal DNA methylation of the validated DMRs in F1 oocytes was also observed in F2 oocytes. Conclusions These results indicate that DNA methylation may mediate the transgenerational inheritance of metabolic disorders induced by undernourishment in utero via female germline.

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Section: Discussionmentioning

confidence: 99%

Inheritance of perturbed methylation and metabolism caused by uterine malnutrition via oocytes

et al. 2023

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“…On the contrary, Japan's slow growth in ow/ob in the next ten years may be related to its social culture in favoring smaller body [ 24 ]. In addition, undernutrition and overnutrition coexist in developing countries undergoing rapid nutrition transition, women are vulnerable to the double burden of undernutrition and overnutrition, which has huge consequences not only for women themselves, but also for children [ 25 ], and animal experiment has shown that perinatal protein malnutrition has intergenerational effects on offspring [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Spatial–temporal trends in global childhood overweight and obesity from 1975 to 2030: a weight mean center and projection analysis of 191 countries

et al. 2023

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Background The geographic information science-based interactive map provided good prospects for the public health to study disease prevalence. The purpose of this study is to understand global spatial–temporal trends of childhood overweight and obesity and underlying causes help formulating intervention strategies. Methods This multiple cross-sectional study included data on childhood overweight and obesity prevalence, gross national income per capita, and urbanization rate for 191 countries from 1975–2016. Autoregressive integrated moving average model, standard deviational ellipse model and mixed-effects models were used to explore spatial–temporal trends of childhood overweight and obesity and associations with gross national income per capita and urbanization rate. Results Globally, childhood overweight and obesity rate would reach 30.0% in 2030 (boys: 34.2%, girls: 27.4%). By 2030, it would reach 58.3% in middle- and high-income countries and 68.1% in Western Pacific region. Spatial–temporal trendline for childhood overweight and obesity in 1975–2030 exhibited a “C” shape, migrating from 1975 (15.6。E, 24.6。N) to 2005 (10.6。E, 21.7。N), then to 2030 (14.8。E, 17.4。N). The trendline for urbanization rate was also an irregular "C", and the turning point appeared five years earlier than childhood overweight and obesity. Conclusions Globally, childhood overweight and obesity prevalence will continue to increase. Its weight mean center migrated from western countries to Asia and Africa following economic development.

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“…Such memory impairment has been closely associated with altered glucocorticoid production, reduced hippocampal mossy fiber area and decreased basal dendritic length (Reyes-Castro et al, 2018). Additionally, Gianatiempo et al (2018) have shown that perinatal PMN alters the mother-offspring interaction which further disrupt the maternal behavior and delay the acquisition of developmental landmarks and neurological reflex development. These behavioral alterations were not restricted to F1 generation only but also transmitted to following generation.…”

Section: Protein Malnutrition and Cns Developmentmentioning

confidence: 99%

Maternal Protein Malnutrition: Current and Future Perspectives of Spirulina Supplementation in Neuroprotection

Sinha

Patro

2018

Front. Neurosci.

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Malnutrition has been widely recognized as a grave burden restricting the progress of underdeveloped and developing countries. Maternal, neonatal and postnatal nutritional immunity provides an effective approach to decrease the risk of malnutrition associated stress in adulthood. Particularly, maternal nutritional status is a critical contributor for determining the long-term health aspects of an offspring. Maternal malnutrition leads to increased risk of life, poor immune system, delayed motor development and cognitive dysfunction in the children. An effective immunomodulatory intervention using nutraceutical could be used to enhance immunity against infections. The immune system in early life possesses enormous dynamic capacity to manage both genetic and environment driven processes and can adapt to rapidly changing environmental exposures. These immunomodulatory stimuli or potent nutraceutical strategy can make use of early life plasticity to target pathways of immune ontogeny, which in turn could increase the immunity against infectious diseases arising from malnutrition. This review provides appreciable human and animal data showing enduring effects of protein deprivation on CNS development, oxidative stress and inflammation and associated behavioral and cognitive impairments. Relevant studies on nutritional supplementation and rehabilitation using Spirulina as a potent protein source and neuroprotectant against protein malnutrition (PMN) induced deleterious changes have also been discussed. However, there are many futuristic issues that need to be resolved for proper modulation of these therapeutic interventions to prevent malnutrition.

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Intergenerational transmission of maternal care deficiency and offspring development delay induced by perinatal protein malnutrition

Abstract: These results highlight the harmful effects of protein malnutrition even for generations that are not directly exposed to this environmental adversity.

Cited by 12 publications

References 51 publications

Inheritance of perturbed methylation and metabolism caused by uterine malnutrition via oocytes

Inheritance of perturbed methylation and metabolism caused by uterine malnutrition via oocytes

Spatial–temporal trends in global childhood overweight and obesity from 1975 to 2030: a weight mean center and projection analysis of 191 countries

Maternal Protein Malnutrition: Current and Future Perspectives of Spirulina Supplementation in Neuroprotection

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