Intergenerational transmission of psychological trauma: A structural neuroimaging study

Sarıgedik, Enes; Naldemir, İbrahim Feyyaz; Karaman, Ahmet Kürşat; Altınsoy, Hasan Baki

doi:10.1016/j.pscychresns.2022.111538

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…For example, significant associations between maternal experiences of childhood maltreatment and infants’ total brain volume ( 41 ), total intracranial volume ( 42 ), amygdala volume ( 43 ), and functional connectivity in the frontoamygdala circuits ( 44 ) have also been reported. In one study, children whose mothers experienced a great earthquake in Turkey demonstrated smaller gray matter volumes in the hippocampus and amygdala ( 45 ). Second, epigenetic inheritance has been suggested to underlie the intergenerational transmission of trauma effect.…”

Section: Introductionmentioning

confidence: 99%

Transmit Radiant Individuality to Offspring (TRIO) study: investigating intergenerational transmission effects on brain development

Matsudaira,

Yamaguchi,

Taki

2023

Front. Psychiatry

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Intergenerational transmission is a crucial aspect of human development. Although prior studies have demonstrated the continuity of psychopathology and maladaptive upbringing environments between parents and offspring, the underlying neurobiological mechanisms remain unclear. We have begun a novel neuroimaging research project, the Transmit Radiant Individuality to Offspring (TRIO) study, which focuses on biological parent-offspring trios. The participants of the TRIO study were Japanese parent-offspring trios consisting of offspring aged 10–40 and their biological mother and father. Structural and functional brain images of all participants were acquired using magnetic resonance imaging (MRI). Saliva samples were collected for DNA analysis. We obtained psychosocial information, such as intelligence, mental health problems, personality traits, and experiences during the developmental period from each parent and offspring in the same manner as much as possible. By April 2023, we completed data acquisition from 174 trios consisting of fathers, mothers, and offspring. The target sample size was 310 trios. However, we plan to conduct genetic and epigenetic analyses, and the sample size is expected to be expanded further while developing this project into a multi-site collaborative study in the future. The TRIO study can challenge the elucidation of the mechanism of intergenerational transmission effects on human development by collecting diverse information from parents and offspring at the molecular, neural, and behavioral levels. Our study provides interdisciplinary insights into how individuals’ lives are involved in the construction of the lives of their descendants in the subsequent generation.

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Section: Introductionmentioning

confidence: 99%

Transmit Radiant Individuality to Offspring (TRIO) study: investigating intergenerational transmission effects on brain development

Matsudaira,

Yamaguchi,

Taki

2023

Front. Psychiatry

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Prenatal Stress and Maternal Role in Neurodevelopment

Thomason,

Hendrix

2024

Annual Review of Developmental Psychology

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This review summarizes recent findings on stress-related programming of brain development in utero, with an emphasis on situating findings within the mothers’ broader psychosocial experiences. Meta-analyses of observational studies on prenatal stress exposure indicate that the direction and size of effects on child neurodevelopment are heterogeneous across studies. Inspired by lifespan and topological frameworks of adversity, we conceptualize individual variation in mothers’ lived experience during and prior to pregnancy as a key determinant of these heterogeneous effects across populations. We structure our review to discuss experiential categories that may uniquely shape the psychological and biological influence of stress on pregnant mothers and their developing children, including current socioeconomic resources, exposure to chronic and traumatic stressors, culture and historical trauma, and the contours of prenatal stress itself. We conclude by identifying next steps that hold potential to meaningfully advance the field of fetal programming.

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Intergenerational transmission of psychological trauma: A structural neuroimaging study

Cited by 2 publications

References 48 publications

Transmit Radiant Individuality to Offspring (TRIO) study: investigating intergenerational transmission effects on brain development

Transmit Radiant Individuality to Offspring (TRIO) study: investigating intergenerational transmission effects on brain development

Prenatal Stress and Maternal Role in Neurodevelopment

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