Interhemispheric functional reorganization after cross nerve transfer: Via cortical or subcortical connectivity?

Hua, Xu‐Yun; Li, Zhan-Yu; Xu, Wendong; Zheng, Mou‐Xiong; Xu, Jian-Guang; Gu, Yajia

doi:10.1016/j.brainres.2012.06.016

Cited by 14 publications

(10 citation statements)

References 22 publications

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“…A previous study reported an “interhemispheric” remodeling pattern of M1 in patients with TBPI after contralateral C7 nerve transfer (Hua, Li, et al., 2012; Hua, Zuo, et al., 2012). In a follow‐up period of 3 years or longer, the silent contralateral M1 was found to be reactivated by movement of the injured hand (Beaulieu et al., 2006; Liu et al., 2013).…”

Section: Discussionmentioning

confidence: 96%

Aberrant central plasticity underlying synchronous sensory phenomena in brachial plexus injuries after contralateral cervical seventh nerve transfer

Cai

Lei

et al. 2021

Brain and Behavior

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Backgrounds Contralateral cervical seventh (C7) nerve transfer aids motor and sensory recovery in total brachial plexus avulsion injuries (TBPI), but synchronous sensation often persists postoperatively. The mechanism underlying synchronous sensory phenomena remain largely unknown. Objective To investigate the role of central plasticity in sensory recovery after contralateral C7 nerve transfer. Methods Sixteen right TBPI patients who received contralateral C7 nerve transfer for more than 2 years were included. Sensory evaluations included Semmes–Weinstein monofilament assessment (SWM), synchronous sensation test, and sensory evoked action potential (SNAP) test. Smaller value in the SWM assessment and larger amplitude of SNAP indicates better tactile sensory. Functional magnetic resonance imaging was performed while stimulations delivered to each hand separately in block‐design trials for central plasticity analysis. Results The SWM value of the injured right hand was increased compared with the healthy left side (difference: 1.76, 95% confidence interval: 1.37–2.15, p < .001), and all 16 patients developed synchronous sensation. In functional magnetic resonance imaging analysis, sensory representative areas of the injured right hand were located in its ipsilateral S1, and 23.4% of this area overlapped with the representative area of the left hand. The ratio of overlap for each patient was significantly correlated with SWM value and SNAP amplitude of the right hand. Conclusion The tactile sensory functioning of the injured hand was dominated by its ipsilateral SI in long‐term observation, and its representative area largely overlapped with the representative area of the intact hand, which possibly reflected a key mechanism of synchronous sensation in patients with TBPI after contralateral C7 transfer.

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Section: Discussionmentioning

confidence: 96%

Aberrant central plasticity underlying synchronous sensory phenomena in brachial plexus injuries after contralateral cervical seventh nerve transfer

Cai

Lei

et al. 2021

Brain and Behavior

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“…Several animal studies about reorganization or compensatory effects within the cerebral cortex have been reported (Pawela et al 2010;Hua et al 2012). Regarding the visual cortex, a clinical study demonstrated that upon damage of the ipsilateral side, an increase in the glucose metabolism of the contralateral side relative to the extent of the damage could be observed (Batista et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Changes in brain glucose metabolism following traumatic optic neuropathy in rats

et al. 2020

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“…[4][5][6] This in turn may result in changes in white matter volume and interhemispheric connectivity. [7][8][9][10] White matter volume changes would be reflected in corpus callosum volumetry. [11][12][13][14][15] As a corollary, disruption of interhemispheric coactivation may result in bilateral effects on the brain.…”

Section: Figurementioning

confidence: 99%

Novel Findings in Obstetric Brachial Plexus Palsy: A Study of Corpus Callosum Volumetry and Resting-State Functional Magnetic Resonance Imaging of Sensorimotor Network

et al. 2017

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Interhemispheric functional reorganization after cross nerve transfer: Via cortical or subcortical connectivity?

Cited by 14 publications

References 22 publications

Aberrant central plasticity underlying synchronous sensory phenomena in brachial plexus injuries after contralateral cervical seventh nerve transfer

Aberrant central plasticity underlying synchronous sensory phenomena in brachial plexus injuries after contralateral cervical seventh nerve transfer

Changes in brain glucose metabolism following traumatic optic neuropathy in rats

Novel Findings in Obstetric Brachial Plexus Palsy: A Study of Corpus Callosum Volumetry and Resting-State Functional Magnetic Resonance Imaging of Sensorimotor Network

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