Interhemispheric Glioependymal Cyst Associated With Agenesis of the Corpus Callosum. Case Report.

Abstract

A male neonate was admitted because prenatal ultrasonography indicated central nervous system abnormalities. Neurological examination showed no abnormality except for electroencephalographic spike activities. Magnetic resonance imaging revealed a cystic lesion in the left interhemispheric fissure, agenesis of the corpus callosum, and microgyria in the left frontotemporal lobes. Cerebral blood flow (CBF) was diffusely reduced. The cyst wall was partially removed and a cyst-peritoneal shunt procedure was performed. The histological diagnosis was glioependymal cyst. The spike activity disappeared and CBF dramatically improved after the operation.

Outcome of 12 antenatally diagnosed fetal arachnoid cysts: Case series and review of the literature

“…Glioependymal cysts are located in the parenchyma of the brain, have an ependymal lining and are rarely reported in association with agenesis of the corpus callosum. 30,31 In contrast to cells lining the arachnoid cysts, they are ciliated and stain with antibodies against glial fibrillary acidic protein. 29 Glioependymal cysts are rarely reported in association with agenesis of the corpus callosum.…”

“…29 Glioependymal cysts are rarely reported in association with agenesis of the corpus callosum. 30,31 Aneurysms of the vein of Galen and other vascular anomalies are easily differentiated from other brain lesions by Color Doppler analysis. Other rare conditions to differentiate are schizencephaly, cystic astrocytoma and teratoma and intraventricular hemorrhage.…”

Contrasting behavior of glio-ependymal cysts: A report of two cases and literature review

“…[3] MR proton spectroscopy remains an inconclusive diagnostic tool till the present time; however, resonance of N-acetyl group of the compound may be a subtle indicator of glial tissue within ependymal lining. [12] Associated congenital brain malformations have been documented in the antenatal period, [6,13] adolescents and elderly. Clinical presentation of raised intracranial pressure may be attributed to the cysts per se while associated developmental anomalies may account for seizures.…”

“…The proliferative nature of these lesions justifies their surgical removal. [13] Surgical intervention may include cysto-peritoneal shunt, [3] cysto-arachnoid shunt, [7] partial excision, [13] marsupilization, [1] fenestration or total excision. [4,8,14] Surgical outcome remains satisfactory without recurrence or repeated surgeries after complete removal.…”

Giant glioependymal cyst in an infant

“…Ependymal cysts are primarily intraaxial and their walls consist of an inner single layer of ependymal lining resting on connective tissue; the outer brain parenchyma is normal. 5,9,11 Glioependymal/neuroglial cysts are located in the paraventricular or subarachnoid space. Their wall consists of 3 layers and a single epithelium directly abuts the inner glial layer, which is not continuous with normal brain parenchyma and outer connective tissue.…”