Interictal electromagnetic source imaging in focal epilepsy: practices, results and recommendations

Leijten, Frans S.S.; Huiskamp, Geertjan

doi:10.1097/wco.0b013e3283081e23

Cited by 30 publications

(27 citation statements)

References 67 publications

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“…Functional imaging modalities such as PET [134–137] and SPECT [138] can be useful in determining the prospective functional deficit zone [92]. Functional MRI [139–142] and magnetic source imaging or magnetoencephalography [143,144] can yield more information about the ictal onset zone and the spatial extent of interictal spiking, often termed the ‘irritative zone’ [8]. The combination of functional imaging modalities with structural neuroimaging and techniques that spatially coregister functional and structural signals (e.g., [81,82]) may elucidate the functional role of damaged hippocampal and extra-hippocampal brain areas in the progression of the disease and the surgical outcome of patients.…”

Section: Future Perspectivementioning

confidence: 99%

Quantitative analysis of structural neuroimaging of mesial temporal lobe epilepsy

Memarian

Thompson²,

Engel³

et al. 2013

Imaging in Medicine

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Mesial temporal lobe epilepsy (MTLE) is the most common of the surgically remediable drug-resistant epilepsies. MRI is the primary diagnostic tool to detect anatomical abnormalities and, when combined with EEG, can more accurately identify an epileptogenic lesion, which is often hippocampal sclerosis in cases of MTLE. As structural imaging technology has advanced the surgical treatment of MTLE and other lesional epilepsies, so too have the analysis techniques that are used to measure different structural attributes of the brain. These techniques, which are reviewed here and have been used chiefly in basic research of epilepsy and in studies of MTLE, have identified different types and the extent of anatomical abnormalities that can extend beyond the affected hippocampus. These results suggest that structural imaging and sophisticated imaging analysis could provide important information to identify networks capable of generating spontaneous seizures and ultimately help guide surgical therapy that improves postsurgical seizure-freedom outcomes.

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Section: Future Perspectivementioning

confidence: 99%

Quantitative analysis of structural neuroimaging of mesial temporal lobe epilepsy

Memarian

Thompson²,

Engel³

et al. 2013

Imaging in Medicine

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“…Many research groups in the past decades have conducted experiments to show the efficacy of using EEG source analysis techniques in the pre-surgical planning for patients diagnosed with focal epilepsy (Ding et al, 2007; Ebersole, 2000; He et al, 1987, 2013; Leijten and Huiskamp, 2008; Lu et al, 2012b, 2014; Michel et al, 1999; Plummer et al, 2008; Sperli et al, 2006; Wang et al, 2011; Yang et al, 2011). Using the interictal spikes found in the EEG of these patients, such techniques can provide a noninvasive way to assist the physician in localizing the epileptogenic foci.…”

Section: Introductionmentioning

confidence: 99%

Effect of EEG electrode number on epileptic source localization in pediatric patients

Sohrabpour

Kankirawatana

et al. 2015

Clinical Neurophysiology

128

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Objective To investigate the relationship between EEG source localization and the number of scalp EEG recording channels. Methods 128 EEG channel recordings of 5 pediatric patients with medically intractable partial epilepsy were used to perform source localization of interictal spikes. The results were compared with surgical resection and intracranial recordings. Various electrode configurations were tested and a series of computer simulations based on a realistic head boundary element model were also performed in order to further validate the clinical findings. Results The improvement seen in source localization substantially decreases as the number of electrodes increases. This finding was evaluated using the surgical resection, intracranial recordings and computer simulation. It was also shown in the simulation that increasing the electrode numbers could remedy the localization error of deep sources. A plateauing effect was seen in deep and superficial sources with further increasing the electrode number. Conclusion The source localization is improved when electrode numbers increase, but the absolute improvement in accuracy decreases with increasing electrode number. Significance Increasing the electrode number helps decrease localization error and thus can more ably assist the physician to better plan for surgical procedures.

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“…There is compelling evidence for the role of electric source imaging (ESI) in the localization of interictal epileptiform discharges [1], [2], [3], [4], [5]. However, the irritative zone generating the interictal EEG discharges might not necessarily coincide with the seizure-onset zone [6].…”

Section: Introductionmentioning

confidence: 99%

Ictal EEG source imaging in presurgical evaluation: High agreement between analysis methods

Beniczky

Rosenzweig

Scherg³

et al. 2016

Seizure

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Interictal electromagnetic source imaging in focal epilepsy: practices, results and recommendations

Cited by 30 publications

References 67 publications

Quantitative analysis of structural neuroimaging of mesial temporal lobe epilepsy

Quantitative analysis of structural neuroimaging of mesial temporal lobe epilepsy

Effect of EEG electrode number on epileptic source localization in pediatric patients

Ictal EEG source imaging in presurgical evaluation: High agreement between analysis methods

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