Interindividual variability and age-dependency of motor cortical plasticity induced by paired associative stimulation

Müller-Dahlhaus, J. Florian M.; Orekhov, Yuriy; Liu, Yali; Ziemann, Ulf

doi:10.1007/s00221-008-1319-7

Cited by 327 publications

(304 citation statements)

References 54 publications

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“…Variability in response to non-invasive brain stimulation is not unique to tDCS, and has also been reported in other techniques such as paired associative stimulation (PAS) and intermittent theta burst stimulation (iTBS) (Fratello et al, 2006;Hamada et al, 2013;LopezAlonso et al, 2014;Muller-Dahlhaus et al, 2008). Given individual differences in anatomy including skull shape, thickness and density; and additional factors such as baseline neuronal states, it is perhaps not surprising that these techniques do not yield identical results across individuals.…”

Section: Introductionmentioning

confidence: 90%

Intra-Subject Consistency and Reliability of Response Following 2 mA Transcranial Direct Current Stimulation

et al. 2016

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. (2016) Intrasubject consistency and reliability of response following 2mA transcranial direct current stimulation. Brain Stimulation, 9 (6). pp. 819-825. ISSN 1876-4754 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/34423/1/Dyke%20et%20al%2018-6-16.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Intra-subject consistency and reliability of response following 2mA transcranial direct current stimulation Abstract BackgroundTranscranial direct current stimulation (tDCS) is a popular non-invasive brain stimulation technique that has been shown to influence cortical excitability. While polarity specific effects have often been reported, this is not always the case, and variability in both the magnitude and direction of the effects have been observed. Objective/ hypothesisWe aimed to explore the consistency and reliability of the effects of tDCS by investigating changes in cortical excitability across multiple testing sessions in the same individuals. A within subjects design was used to investigate the effects of anodal and cathodal tDCS applied to the motor cortex. Four experimental sessions were tested for each polarity in addition to two sham sessions. MethodsTranscranial Magnetic Stimulation (TMS) was used to measure cortical excitability (TMS recruitment curves). Changes in excitability were measured by comparing baseline measures and those taken immediately following 20minutes of 2mA stimulation or sham stimulation. ResultsAnodal tDCS significantly increased cortical excitability at a group level, whereas cathodal tDCS failed to have any significant effects. The sham condition also failed to show any significant changes.Analysis of intra-subject responses to anodal stimulation across four sessions suggest that the amount of change in excitability across sessions was only weakly associated, and was found to have poor reliability acro...

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Section: Introductionmentioning

confidence: 90%

Intra-Subject Consistency and Reliability of Response Following 2 mA Transcranial Direct Current Stimulation

et al. 2016

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“…For instance, advanced age is linked with reduced capacity for plasticity and is very common in the population of ischemic stroke patients [51,[113][114][115][116][117]. Therefore, it will be necessary to define whether advanced age affects the efficacy of VNS in the context of stroke, in order to determine the patient population most likely to respond to the therapy.…”

Section: Challenges For Translating Vns Therapies Into Clinical Practmentioning

confidence: 99%

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Hays

2016

Neurotherapeutics

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Pathological neural activity could be treated by directing specific plasticity to renormalize circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit changes after neurological disease or injury, but insufficient or maladaptive plasticity often prevents a full recovery. The development of adjunctive strategies that broadly support plasticity to facilitate the benefits of rehabilitative interventions has the potential to improve treatment of a wide range of neurological disorders. Recently, stimulation of the vagus nerve in conjunction with rehabilitation has emerged as one such potential targeted plasticity therapy. Vagus nerve stimulation (VNS) drives activation of neuromodulatory nuclei that are associated with plasticity, including the cholinergic basal forebrain and the noradrenergic locus coeruleus. Repeatedly pairing brief bursts of VNS sensory or motor events drives robust, event-specific plasticity in neural circuits. Animal models of chronic tinnitus, ischemic stroke, intracerebral hemorrhage, traumatic brain injury, and post-traumatic stress disorder benefit from delivery of VNS paired with successful trials during rehabilitative training. Moreover, mounting evidence from pilot clinical trials provides an initial indication that VNS-based targeted plasticity therapies may be effective in patients with neurological diseases and injuries. Here, I provide a discussion of the current uses and potential future applications of VNS-based targeted plasticity therapies in animal models and patients, and outline challenges for clinical implementation.

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“…Only those subjects with RMTp50% of maximum stimulator output (n ¼ 22) were retained for a second screening step (PAS LTP screening) because RMT450% of maximum stimulator output is associated with a low probability for a LTP-like response after PAS LTP (Müller-Dahlhaus et al, 2008). After a second screening step, nine subjects were retained and enrolled into this study that exhibited a significant PAS LTP -induced increase in MEP amplitudeX1.2 (ratio of MEP amplitude post-PAS/pre-PAS) (Heidegger et al, 2010;Korchounov and Ziemann, 2011).…”

Section: Subjectsmentioning

confidence: 99%

“…After a second screening step, nine subjects were retained and enrolled into this study that exhibited a significant PAS LTP -induced increase in MEP amplitudeX1.2 (ratio of MEP amplitude post-PAS/pre-PAS) (Heidegger et al, 2010;Korchounov and Ziemann, 2011). Therefore, this selection excluded subjects with a long-term depression-like MEP decrease or no MEP change following PAS LTP (Müller-Dahlhaus et al, 2008), as the explicit aim of this study was to study drug effects on LTP-like plasticity, a process with significant relation to motor learning (Jung and Ziemann, 2009;Kang et al, 2011;Rosenkranz et al, 2007;Ziemann et al, 2004), rather than exploring drug effects on a great variety of magnitudes and directions of PAS LTP -induced plasticity in the general population.…”

Section: Subjectsmentioning

confidence: 99%

“…PAS LTP was performed according to a protocol originally described by (Stefan et al, (2000)) and later on slightly modified by our group (Müller et al, 2007;Müller-Dahlhaus et al, 2008). It consisted of 225 pairs of electrical stimulation of the right median nerve at the wrist followed by TMS delivered at a rate of 0.25 Hz (duration: 15 min).…”

Section: Paired Associative Stimulation (Pas Ltp )mentioning

confidence: 99%

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Deleterious Effects of a Low Amount of Ethanol on LTP-Like Plasticity in Human Cortex

Lücke

Heidegger

Röhner

et al. 2014

Neuropsychopharmacol

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Ingesting ethanol (EtOH) at low doses during social drinking is a common human behavior for its facilitating effects on social interactions. However, low-dose EtOH may have also detrimental effects that so far are underexplored. Here we sought to test the effects of lowdose EtOH on long-term potentiation (LTP)-like plasticity in human motor cortex. Previous cellular experiments showed that low-dose EtOH potentiates extrasynaptic GABAAR and reduces NMDAR-mediated currents, processes that would limit the expression of LTP. Paired associative transcranial magnetic stimulation (PAS LTP ) was employed in nine healthy subjects for induction of LTP-like plasticity, indexed by a long-term increase in motor-evoked potential input-output curves. Synaptic a1-GABAAR function was measured by saccadic peak velocity (SPV). Very low doses of EtOH (resulting in blood concentrations of o5 mM) suppressed LTP-like plasticity but did not affect SPV when compared with a placebo condition. In contrast, 1 mg of alprazolam, a classical benzodiazepine, or 10 mg of zolpidem, a non-benzodiazepine hypnotic, decreased SPV but did not significantly affect LTP-like plasticity when compared with placebo. This double dissociation of low-dose EtOH vs alprazolam/zolpidem effects is best explained by the putatively high affinity of EtOH but not alprazolam/zolpidem to extrasynaptic GABAARs and to NMDARs. Findings suggest that enhancement of extrasynaptic GABAARmediated tonic inhibition and/or reduction of NMDAR-mediated neurotransmission by EtOH blocks LTP-like plasticity in human cortex at very low doses that are easily reached during social drinking. Therefore, low-dose EtOH may jeopardize LTP-dependent processes, such as learning and memory formation.

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Interindividual variability and age-dependency of motor cortical plasticity induced by paired associative stimulation

Cited by 327 publications

References 54 publications

Intra-Subject Consistency and Reliability of Response Following 2 mA Transcranial Direct Current Stimulation

Intra-Subject Consistency and Reliability of Response Following 2 mA Transcranial Direct Current Stimulation

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Deleterious Effects of a Low Amount of Ethanol on LTP-Like Plasticity in Human Cortex

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