Interindividual variability of soil arsenic metabolism by human gut microbiota using SHIME model

Yin, Naiyi; Du, Hongwang; Wang, Pengfei; Cai, Xiaolin; Chen, Peng; Sun, Guoxin

doi:10.1016/j.chemosphere.2017.06.018

Cited by 25 publications

(6 citation statements)

References 52 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study showed that 100 ppb arsenic exposure for 13 weeks changed the gut microbial composition and altered important microbial functional pathways (carbohydrate metabolism [especially pyruvate fermentation], short-chain fatty acid synthesis, and starch utilization) that could influence host metabolism (38). Moreover, child gut microbiota exhibit high levels of As III , the more toxic form of arsenic, which could result in increased health risk (39).…”

mentioning

confidence: 99%

Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

Gokulan

Arnold

Jensen

et al. 2018

mBio

View full text Add to dashboard Cite

Intestinal microbiota composition and gut-associated immune response can contribute to the toxicity of arsenic. We investigated the potential toxicity of short-term arsenic exposure on gut microbiome composition, intestinal immune status, microbial arsenic resistance gene, and arsenic metabolic profiles in adult and developmental stages of CD-1 mice. The potential toxicity of arsenite [As(III)] was determined for two life stages: (i) adult animals at 24 or 48 h after single gavage (0.05 mg/kg body weight [b.w.] [low dose], 0.1 mg/kg b.w. [medium dose], and 0.2 mg/kg b.w. [high dose]) and repeated exposure at 1 mg/liter for 8 days and (ii) postnatal day 10 (PND10) and PND21 after single gavage (0.05 mg/kg b.w.). Dose- and time-dependent responses in bacterial recovery/microbial composition were observed in adults after a single gavage. Repeated exposure caused a transient decrease in the recovery of intestinal bacteria, a shift in the bacterial population with abundance of arsenic resistance genes, and evidence for host metabolism of arsenite into less-reactive trivalent methylated species. Arsenic exposure in adult animals induced high levels of CC chemokines and of proinflammatory and anti-inflammatory cytokine secretion in intestine. Arsenic exposure at PND21 resulted in the development of distinct bacterial populations. Results of this study highlight significant changes in the intestinal microbiome and gut-associated immune status during a single or repeated exposure to arsenic in juvenile and adult animals. The data warrant investigation of the long-term effects of oral arsenic exposure on the microbiome and of immune system development and responses. Transformation of organic arsenic to toxic inorganic arsenic (iAs) is likely carried out by intestinal bacteria, and iAs may alter the viability of certain microbial populations. This study addressed the impact of arsenic exposure on intestinal microbiota diversity and host gut-associated immune mediators during early development or adulthood using scenarios of acute or repeated doses. During acute arsenic exposure, animals developed defense functions characterized by higher abundances of bacteria that are involved in arsenic resistance or detoxification mechanisms. Arsenite had a negative effect on the abundance of bacterial species that are involved in the conversion of protein to butyrate, which is an alternative energy source in the intestine. The intestinal mucosal immune cytokine profile reflected a mechanism of protection from arsenic toxicity.

show abstract

mentioning

confidence: 99%

Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

Gokulan

Arnold

Jensen

et al. 2018

mBio

View full text Add to dashboard Cite

show abstract

“…In one instance the encoding arsM was found adjacent to an arsC , suggesting that this particular ArsM is part of an organized arsenic resistance response for a ( Para ) Bacteroides organism. ArsM functional variability would contribute to inter‐individual microbiome uniqueness (Eckburg et al ., ; O'Toole, ; Ukhanova et al ., ; Pérez‐Cobas et al ., ), which is supported by a SHIME‐based study that concluded arsenic methylation varies between individuals and particularly when comparing adults to children (Yin et al ., ). Again, however, there are caveats.…”

Section: Arsenic and The Git Microbiomementioning

confidence: 97%

Arsenic and the gastrointestinal tract microbiome

McDermott

Stolz

Oremland

2020

Environ Microbiol Rep

View full text Add to dashboard Cite

Summary Arsenic is a toxin, ranking first on the Agency for Toxic Substances and Disease Registry and the Environmental Protection Agency Priority List of Hazardous Substances. Chronic exposure increases the risk of a broad range of human illnesses, most notably cancer; however, there is significant variability in arsenic‐induced disease among exposed individuals. Human genetics is a known component, but it alone cannot account for the large inter‐individual variability in the presentation of arsenicosis symptoms. Each part of the gastrointestinal tract (GIT) may be considered as a unique environment with characteristic pH, oxygen concentration, and microbiome. Given the well‐established arsenic redox transformation activities of microorganisms, it is reasonable to imagine how the GIT microbiome composition variability among individuals could play a significant role in determining the fate, mobility and toxicity of arsenic, whether inhaled or ingested. This is a relatively new field of research that would benefit from early dialogue aimed at summarizing what is known and identifying reasonable research targets and concepts. Herein, we strive to initiate this dialogue by reviewing known aspects of microbe–arsenic interactions and placing it in the context of potential for influencing host exposure and health risks. We finish by considering future experimental approaches that might be of value.

show abstract

“…The high variability in microbiota may suggest the diversity of the As metabolic potency among different people. A recent study confirmed that the degree of As methylation by gut bacteria from different healthy individuals was largely different [140]. Another in vitro study suggested that Fe 3+ decreased the As bioaccessibility and increased As methylation by altering the gut microbiota composition [141].…”

Section: Gut Microbiome and As Susceptibilitymentioning

confidence: 97%

Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome

Chi

Gao

et al. 2018

Mamm Genome

View full text Add to dashboard Cite

Arsenic (As) contamination in water or food is a global issue affecting hundreds of millions of people. Although As is classified as a group 1 carcinogen and is associated with multiple diseases, the individual susceptibility to As-related diseases is highly variable, such that a proportion of people exposed to As have higher risks of developing related disorders. Many factors have been found to be associated with As susceptibility. One of the main sources of the variability found in As susceptibility is the variation in the host genome, namely, polymorphisms of many genes involved in As transportation, biotransformation, oxidative stress response and DNA repair affect the susceptibility of an individual to As toxicity and then influence the disease outcomes. In addition, lifestyles and many nutritional factors, such as folate, vitamin C, and fruit, have been found to be associated with individual susceptibility to As-related diseases. Recently, the interactions between As exposure and the gut microbiome have been of particular concern. As exposure has been shown to perturb gut microbiome composition, and the gut microbiota has been shown to also influence As metabolism, which raises the question of whether the highly diverse gut microbiota contributes to As susceptibility. Here, we review the literature and summarize the factors, such as host genetics and nutritional status, that influence As susceptibility, and we also present potential mechanisms of how the gut microbiome may influence As metabolism and its toxic effects on the host to induce variations in As susceptibility. Challenges and future directions are also discussed to emphasize the importance of characterizing the specific role of these factors in inter-individual susceptibility to As-related diseases.

show abstract

Interindividual variability of soil arsenic metabolism by human gut microbiota using SHIME model

Cited by 25 publications

References 52 publications

Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

Arsenic and the gastrointestinal tract microbiome

Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome

Contact Info

Product

Resources

About