Interindividual Variation in Cardiorespiratory Fitness: A Candidate Gene Study in Han Chinese People

Abstract

Cardiorespiratory fitness, as assessed through peak oxygen uptake (VO2peak), is a powerful health indicator. We aimed to evaluate the influence of several candidate causal genetic variants on VO2peak level in untrained Han Chinese people. A total of 1009 participants (566 women; age [mean ± SD] 40 ± 14 years, VO2peak 29.9 ± 7.1 mL/kg/min) performed a maximal incremental cycling test for VO2peak determination. Genomic DNA was extracted from peripheral whole blood, and genotyping analysis was performed on 125 gene variants. Using age, sex, and body mass as covariates, and setting a stringent threshold p-value of 0.0004, only one single nucleotide polymorphism (SNP), located in the gene encoding angiotensin-converting enzyme (rs4295), was associated with VO2peak (β = 0.87; p < 2.9 × 10−4). Stepwise multiple regression analysis identified a panel of three SNPs (rs4295 = 1.1%, angiotensin II receptor type 1 rs275652 = 0.6%, and myostatin rs7570532 = 0.5%) that together accounted for 2.2% (p = 0.0007) of the interindividual variance in VO2peak. Participants carrying six ‘favorable’ alleles had a higher VO2peak (32.3 ± 8.1 mL/kg/min) than those carrying only one favorable allele (24.6 ± 5.2 mL/kg/min, p < 0.0001). In summary, VO2peak at the pre-trained state is partly influenced by several polymorphic variations in candidate genes, but they represent a minor portion of the variance.

Association of mitochondrial DNA haplogroups J and K with low response in exercise training among Finnish military conscripts

“…More than half of the inter-individual differences in maximal oxygen uptake (VO 2 max) is determined by a polygenic effect [ 1 , 2 ]. In addition, at least 97 genes in nuclear or mitochondrial genomes have been identified to affect VO 2 max trainability [ 3 ], and variation in mitochondria-related genes is associated with exercise response phenotypes [ 4 ].…”

Inter-Individual Variability of a High-Intensity Interval Training With Specific Techniques vs. Repeated Sprints Program in Sport-Related Fitness of Taekwondo Athletes

“…Accordingly, the inter-individual variability of observed responses to training, such as HIIT, according to the study by Walsh et al (2020) , is a combination of: (i) individual responses to perseverative exercise training (subject-training interaction), (ii) day-to-day biological variation and TE (random variation), and (iii) physiological responses associated with behavioral/maturational changes, not attributable to exercise (e.g., within-person variability) ( Walsh et al, 2020 ). This includes genetic ( Mann et al, 2014 ; Sparks, 2017 ; Bonafiglia et al, 2020 ; Del Coso et al, 2020 ), climatic ( Corbett et al, 2018 ), cognitive ( Atkinson and Batterham, 2015 ), stress and sleep status ( Mann et al, 2014 ), gender, age, time of day variation ( Mann et al, 2014 ; Sparks, 2017 ), training status ( Pickering and Kiely, 2019 ), physiological ( Williamson et al, 2017 ; Atkinson et al, 2019 ), and statistical outcomes ( Swinton et al, 2018 ; Bonafiglia et al, 2020 ; Chrzanowski-Smith et al, 2020 ).…”

Effects of High-Intensity Interval Training With Specific Techniques on Jumping Ability and Change of Direction Speed in Karate Athletes: An Inter-individual Analysis

“…within-person variability; Walsh et al, 2020 ). This includes genetic ( Mann et al, 2014 ; Sparks, 2017 ; Bonafiglia et al, 2020 ; Del Coso et al, 2020 ), climatic ( Corbett et al, 2018 ), cognitive ( Atkinson and Batterham, 2015 ), stress and sleep status ( Mann et al, 2014 ), gender, age, time of day variation ( Mann et al, 2014 ; Sparks, 2017 ), training status ( Pickering and Kiely, 2019 ), physiological ( Williamson et al, 2017 ; Atkinson et al, 2019 ), and statistical ( Swinton et al, 2018 ; Chrzanowski-Smith et al, 2020 ).…”