We report the reversible magnetization of the Ca 2−x Na x CuO 2 Cl 2 ͑x = 0.18͒ single crystal for H ʈ c up to 1.2 T to study the effect of oxygen replacement by chlorine at the apical site. The superconducting transition temperature T c ͑ϳ27 K͒ of this single crystal is the highest reported in this family. Various thermodynamic parameters, such as the penetration depth ab ͑0͒, the coherence length ab ͑0͒, the critical field H c ͑0͒, the upper critical field H c2 ͑0͒ and the Ginzburg-Landau parameter , are also reported. Compared to the iso-structural compound La 1.82 Sr 0.18 CuO 4 with apical oxygen, Ca 1.82 Na 0.18 CuO 2 Cl 2 has two significant differences: ͑1͒ ab ͑0͒ is larger, so the Cooper pair density is quite reduced, and ͑2͒ the anisotropic nature is more enhanced. From these observations, chlorine at the apical site is thought to be less effective than oxygen in supplying charge carriers to the CuO 2 planes; as a result, the interlayer coupling between the CuO 2 planes is weakened.