1987
DOI: 10.1172/jci112806
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Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor.

Abstract: Monokine-stimulated endothelial cells are known to produce both burst-and colony-stimulating activities, but neither the nature of the monokine nor the hematopoietic growth factor(s) produced is known. We show by mRNA analysis that an immortalized line of human endothelial cells constitutively produce grknulocyte-macrophage colony-stimulating factor. Furthermore, interleukin 1 and tumor necrosis factor induce early passage human umbilical endothelial cells to produce the same growth factor.

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Cited by 196 publications
(61 citation statements)
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“…[37][38][39][40][41][42][43][44][45][46][47] The relationship between the production of these cytokines and the functional ability of EC to support hematopoiesis may help in understanding the role played by these cells in the ontogeny of the hematopoietic system as EC are intimately associated with embryonic hematopoiesis and may be involved in the development of embryonic progenitors. 52,53 EC are also part of the bone marrow stromal microenvironment.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…[37][38][39][40][41][42][43][44][45][46][47] The relationship between the production of these cytokines and the functional ability of EC to support hematopoiesis may help in understanding the role played by these cells in the ontogeny of the hematopoietic system as EC are intimately associated with embryonic hematopoiesis and may be involved in the development of embryonic progenitors. 52,53 EC are also part of the bone marrow stromal microenvironment.…”
Section: Discussionmentioning
confidence: 99%
“…[37][38][39][40][41][42][43][44][45][46][47] The functional importance of this production remains to be fully appreciated. As a direct relevant application, EC may for instance offer an improved alternative to unfractionated stroma cells as a source of feeder cells in bioreactors devised for ex vivo expansion of hematopoietic progenitors.…”
Section: Introductionmentioning
confidence: 99%
“…For instance, acute and chronic infections trigger the release of the pro-inflammatory cytokines IL-1β, IL-6, and TNFα that stimulate the host innate immune response. When stimulated by IL-1β or TNFα, BM endothelial cells (BM ECs) upregulate their cytokine production and adhesion molecules [4][5][6]. Physiologically, these events may facilitate the recruitment of inflammatory cells to contain the infection and, at the same time, impact on steady-state hematopoiesis such that progenitor's expansion and differentiation may be modulated to respond to stress.…”
Section: Introductionmentioning
confidence: 99%
“…Its biological activities include induction of various cytokines. IL-1 has been shown to induce the production of granulocytemacrophage colony-stimulating factor [5][6][7][8][9][10][11][12][13], granulocyte CSF (G-CSF) [9][10][11][12] and B-cell stimulatory factor-2/interleukin-6/interferon-fl2 (IFN-~2)/26-kDa protein [14][15][16][17]. Recently it has also been reported that IL-1 can induce its own synthesis [18][19][20].…”
Section: Introductionmentioning
confidence: 99%