Interleukin-1 receptor antagonist: a promising cytokine against human squamous cell carcinomas

Ding, Yujie; Yi, Jie; Sun, Zhenfeng

doi:10.1016/j.heliyon.2023.e14960

Cited by 8 publications

(3 citation statements)

References 139 publications

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“…Polymorphisms in IL1A can increase the risk of ischemic stroke and coronary artery disease (33, 34). IL1A allele 2 might influence the inflammatory environment in vascular endothelium and significantly increase the susceptibility of carotid atherosclerosis (35).…”

Section: Discussionmentioning

confidence: 99%

Inflammation and endothelial function relevant genetic polymorphisms, carotid atherosclerosis, and vascular events in high-risk stroke population

Chen,

Qing,

Luo

et al. 2024

Front. Neurol.

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AimTo identify the associations of 19 single nucleotide polymorphisms (SNPs) in genes involved in inflammation and endothelial function and carotid atherosclerosis with subsequent ischemic stroke and other vascular events in the high-risk stroke population.MethodsThis was a multicenter community-based sectional survey and prospective cohort study in Sichuan, southwestern China. Eight communities were randomly selected, and the residents in each community were surveyed using a structured face-to-face questionnaire. Carotid ultrasonography and DNA information were obtained from 2,377 out of 2,893 individuals belonging to a high-risk stroke population. Genotypes of the 19 SNPs in genes involved in inflammation and endothelial function were measured. All the 2,377 subjects were followed up for 4.7 years after the face-to-face survey. The primary outcome was ischemic stroke, and the secondary outcome was a composite of vascular events.ResultsAmong the 2,377 subjects, 2,205 (92.8%) completed a 4.7-year follow-up, 947 (42.9%) had carotid atherosclerosis [372 (16.9%) carotid vulnerable plaque, 405 (18.4%) mean IMT > 0.9 mm, 285 (12.0%) carotid stenosis ≥15%]. Outcomes occurred in 158 (7.2%) subjects [92 (4.2%) ischemic stroke, 17 (0.8%) hemorrhagic stroke, 48 (2.2%) myocardial infarction, and 26 (1.2%) death] during follow-up. There was a significant gene–gene interaction among ITGA2 rs1991013, IL1A rs1609682, and HABP2 rs7923349 in the 19 SNPs. The multivariate logistic regression model revealed that carotid atherosclerosis and the high-risk interactive genotypes among the three SNPs were independent with a higher risk for ischemic stroke (OR = 2.67, 95% CI: 1.52–6.78, p = 0.004; and OR = 3.11, 95% CI: 2.12–9.27, p < 0.001, respectively) and composite vascular events (OR = 3.04, 95% CI: 1.46–6.35, p < 0.001; and OR = 3.23, 95% CI: 1.97–8.52, p < 0.001, respectively).ConclusionThe prevalence of carotid atherosclerosis was shown to be very high in the high-risk stroke population. Specific SNPs, interactions among them, and carotid atherosclerosis were independently associated with a higher risk of ischemic stroke and other vascular events.

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Section: Discussionmentioning

confidence: 99%

Inflammation and endothelial function relevant genetic polymorphisms, carotid atherosclerosis, and vascular events in high-risk stroke population

Chen,

Qing,

Luo

et al. 2024

Front. Neurol.

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“…These factors regulate immune responses, while IL-8 is the main chemotactic factor. Together, they are involved in vital regulation of cellular processes and play an important role in the pathogenesis of a number of inflammatory diseases [27,[32][33][34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Selective Upregulation of Interleukin 1 Receptor Antagonist and Interleukin-8 in Fuchs’ Endothelial Corneal Dystrophy with Accompanying Cataract

Fiolka,

Wylęgała,

Toborek

et al. 2024

JCM

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(1) Background: Patients with Fuchs’ endothelial corneal dystrophy (FECD) may have coexisting cataracts and, therefore, may require a cataract surgery, which poses challenges due to potential endothelial cell damage. FECD is a degenerative eye disease of unclear etiology, with inflammatory cytokines maybe playing an important role in its development and progression. The present study aimed to investigate the cytokine profile in the aqueous humor of FECD eyes with cataract. (2) Methods: Fifty-two patients were included in the study, 26 with FECD + cataract and 26 with cataract as a control group. Samples of the aqueous humor were analyzed for pro- and anti-inflammatory cytokines using a Bio-Plex 200 system. (3) Results: Interleukin 1 receptor antagonist (IL-1Ra) and interleukin IL-8 levels were significantly higher in the aqueous humor of FECD + cataract patients compared to the control/cataract group. Moreover, the levels of anti-inflammatory IL-10 showed a strong trend to be higher in the FECD + cataract group compared to the control group. In contrast, there were no statistically significant differences in IL-1β, IL-6, IL-4, IL-10, IL-13, IL-17A, and tumor necrosis factor TNF-α between the groups. (4) Conclusions: Presented research contributes to a better understanding of FECD pathogenesis. Elevated levels of IL-1Ra and IL-8 may serve as a defense mechanism in people with FECD and coexisting cataract.

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“…IL-1RA upregulation protects epithelial cells from environmental stimuli by competing with IL-1α. 17 Furthermore, IL-1RA can inhibit tumor angiogenesis and metabolism by blocking IL-1β. Considering its anti-inflammatory and antioncogenic effects, 17 enhancing the expression of IL-1RA can be a potential new strategy for cancer treatment.…”

Section: Role Of Inflammation-related Mediators In the Progression Of...mentioning

confidence: 99%

The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma

Li,

Zeng,

Liu

et al. 2023

JIR

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Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck tissues, is characterized by high rates of recurrence and metastasis. Inflammation is important in HNSCC prognosis. Inflammatory cells and their secreted factors contribute to the various stages of HNSCC development through multiple mechanisms. In this review, the mechanisms through which inflammatory factors, signaling pathways, and cells contribute to the initiation and progression of HNSCC have been discussed in detail. Furthermore, the diagnostic and therapeutic potential of targeting inflammation in HNSCC has been discussed to gain new insights into improving patient prognosis.

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Interleukin-1 receptor antagonist: a promising cytokine against human squamous cell carcinomas

Cited by 8 publications

References 139 publications

Inflammation and endothelial function relevant genetic polymorphisms, carotid atherosclerosis, and vascular events in high-risk stroke population

Inflammation and endothelial function relevant genetic polymorphisms, carotid atherosclerosis, and vascular events in high-risk stroke population

Selective Upregulation of Interleukin 1 Receptor Antagonist and Interleukin-8 in Fuchs’ Endothelial Corneal Dystrophy with Accompanying Cataract

The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma

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