Interleukin-10 as a novel biomarker of metabolic risk factors

Kulshrestha, Himani; Gupta, Vishal; Mishra, Sameeksha; Mahdi, Abbas Ali; Awasthi, Shelly; Kumar, Sandeep

doi:10.1016/j.dsx.2018.03.019

Cited by 16 publications

(8 citation statements)

References 27 publications

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“…Leptin is a pro-inflammatory adipokine involved in increased CV risk-score whereas adiponectin has protective effects on the cardiovascular system (31,32), possibly due to the induction of IL-10 production (33,34), an antiinflammatory cytokine produced by different cells such as T helper cells, B cells and macrophages. IL-10 is inversely correlated with BMI and multiple metabolic risk factors (35,36). As expected, in the present study, a positive correlation between IL-10 and plasma adiponectin levels in both sexes, and a negative correlation with calculated CV risk-score in males, who presented a higher calculated CV risk-score than females, were observed.…”

Section: Discussionsupporting

confidence: 88%

“…Conversely, no difference between men and women regarding levels of the proinflammatory cytokine IL-6 or the anti-inflammatory IL-10 was found. Possibly, the inverse correlation between IL-10 and calculated CV risk-score observed only among men is a metabolic attempt to limit inflammation, protecting them from CV disease (35,36). It has been shown that CRP is related to different adiposity indices such as total body fat and VAT (37,38).…”

Section: Discussionmentioning

confidence: 99%

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Association between visceral/subcutaneous adipose tissue ratio and plasma inflammatory markers and score for cardiovascular risk prediction in a Brazilian cohort: Pró-Saúde Study

Pereira-Manfro

Lima

Neto

et al. 2021

Braz J Med Biol Res

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Visceral adipose tissue (VAT) is associated with various metabolic disorders, and adipokines, secreted by adipose tissue, are involved in their pathogenesis. This study investigated associations between VAT/subcutaneous adipose tissue (SAT) ratio, inflammatory markers, and cardiovascular (CV) risk-score in adults. Plasma levels of adipokines, plasma lipid profile, blood pressure, and body composition (using dual-emission x-ray absorptiometry) were determined. CV risk-score based on the American College of Cardiology and the American Heart Association (ACC/AHA) score was calculated in a sample of 309 Brazilian civil servants aged o60 years. Participants' VAT/SAT ratio were categorized into quartiles. Among males, plasma leptin (2.8 ng/mL) and C reactive protein (CRP) (0.2 mg/dL) (Po0.05) levels were higher at P75 and P50 than P5, and the highest calculated CV risk-score was observed at P75 (7.1%). Among females, higher plasma adiponectin levels were observed at P25 (54.3 ng/mL) compared with P75 (36 ng/mL) (Po0.05). Higher plasma CRP levels were observed at P75 (0.4 mg/dL) compared with P5 (0.1 mg/dL) (Po0.05). Higher CV risk-score was observed at P75 (2.0%) compared with P5 (0.7%). In both sexes, VAT and VAT/SAT ratio were directly associated with plasma leptin, CRP, and CV risk-score, and inversely associated with adiponectin; SAT was directly associated with plasma leptin and CRP (Po0.01); interleukin (IL)-10 and CRP were directly associated with adiponectin and leptin, respectively (Po0.05). Among men only, IL-10 (inversely) and CRP (directly) were associated with CV risk-score (P=0.02). Our results strengthened the relevance of the VAT/SAT ratio in cardiovascular risk.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Association between visceral/subcutaneous adipose tissue ratio and plasma inflammatory markers and score for cardiovascular risk prediction in a Brazilian cohort: Pró-Saúde Study

Pereira-Manfro

Lima

Neto

et al. 2021

Braz J Med Biol Res

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“…On the other hand, serum levels of circulating IL-10 were signi cantly lower in the obese with diabetes rather than the control group. Similar ndings were reported that subjects with low IL-10 production capacity have an increased risk of MS such as type 2 diabetes mellitus [24,25]. Another study shows contrast result that IL-10 level increased in obese subjects with MS compared to obese subjects without MS to inhibit continued pro-in ammatory cytokine production [26].…”

Section: Discussionsupporting

confidence: 78%

Comparison of Gut Microbiota and Serum Biomarkers in Obese Patients Diagnosed with Diabetes and Hypothyroid Disorder

Tabasi

Eybpoosh

Heravi

et al. 2020

Preprint

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Background Variations of serum biomarkers and bacterial diversity of the gastrointestinal tract in obese patients with diabetes or hypothyroid are poorly understood. This study broadened our understanding of recent findings in this regard. Methods A total of 120 obese patients (18 with diabetes, 23 with hypothyroid, and 79 patients without either diabetes or hypothyroid (control)) were recruited in this study. Serum biomarkers such as biochemical, hormonal (insulin and glucagon), and cytokine levels (IL-6, IL-1β, TNF-α, IL-10, and TGF–β 1) were measured under fasting conditions. Bacterial diversity of gut microbiota was also quantitated by real-time PCR using 16S rRNA gene-based specific primers. Results Average value of blood sugar (P: 0.0184), insulin, HOMA-IR, TGF-β 1, IL-6, IL-1β, IFNγ, IL-10 (Pfor each < 0.001), phylum Actinobacteria (OR: 1.5, P: 0.032), Firmicutes (OR: 0.6 P: 0.058), and Akkermansia muciniphilai (OR: 0.4, P: 0.053) was significantly different in diabetic vs. non-diabetic obese patients but was not significantly different in hypothyroid vs. non-hypothyroid obese patients. Average value of Bifidobacterium, Bacteroidetes, Prevotella spp., Bacteroides fragilis group, Clostridium cluster IV, Roseburia spp., and Firmicutes to Bacteroidetes ratio (F/B) was not significantly different between these groups either in crude or adjusted models. Conclusion While there are some associations between serum biomarkers or bacterial diversity with diabetes prediction in obese patients, this prognostication is less likely in obese patients with hypothyroid. Further investigation is warranted in the application of identified preclinical biomarkers in the diagnosis of diabetes or hypothyroid in obese patients.

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“…It can be assumed that a decrease in IL-10 concentration may signal the exhaustion of the mechanisms of physiological metabolic control [42]. Measurement of IL-10 concentration may indicate the pro-inflammatory cytokines activation [43]. Pestana et al [44] demonstrated much higher concentrations of IL-6 and TNF-α along with a higher concentration of IL-10 in the blood plasma of patients with type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression

Kurianowicz

Klatka

Polak

et al. 2021

IJMS

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Type 1 diabetes (DM1) is classified as an autoimmune disease. An uncontrolled response of B and T lymphocytes to the body’s own tissues develops in the absence of immune tolerance. The main aim of the study was to evaluate the effect of the duration of type 1 diabetes in children on the expression of TLR receptors and the relationship with the parameters of glycemic control in patients. As a result, we showed significant differences in the level of TLR2, TLR4 and TLR9 expression in patients with DM1 in the early stage of the disease and treated chronically compared to the healthy group. Additionally, in this study, we found that the numbers of CD19+ B cells, CD3+ CD4+, CD3+ CD8+ T cells and NK cells are different for newly diagnosed DM1 individuals, patients receiving chronic treatment and for healthy controls, indicating an important role of these cells in killing pancreatic beta cells. Moreover, higher levels of IL-10 in patients with newly diagnosed DM1 have also been found, confirming the reports found in the literature.

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Interleukin-10 as a novel biomarker of metabolic risk factors

Cited by 16 publications

References 27 publications

Association between visceral/subcutaneous adipose tissue ratio and plasma inflammatory markers and score for cardiovascular risk prediction in a Brazilian cohort: Pró-Saúde Study

Association between visceral/subcutaneous adipose tissue ratio and plasma inflammatory markers and score for cardiovascular risk prediction in a Brazilian cohort: Pró-Saúde Study

Comparison of Gut Microbiota and Serum Biomarkers in Obese Patients Diagnosed with Diabetes and Hypothyroid Disorder

Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression

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