Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis

Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

“…In this study, the frequency of the IL-10 -1082 locus G allele was very similar to that reported for Mainland Chinese (Ma et al, 2007) and Japanese (6.5%) (Ide et al, 2002) populations, which largely differ from that in Cambodians (48%) (Delgado et al, 2002) and Turks (37.7%) (Oral et al, 2006). The frequency of the IL-10 -1082 locus G allele mutation was reported to be higher among Chinese individuals (25%) in one study, but the sample size was small and the variation was relatively large.…”

“…After Bonferroni correction to adjust for multiple testing as well as controlling for the effects of environmental factors such as the history of exposure to TB, family history of TB, and BCG scar in this study, the IL-6 -572 locus was still significantly related to the occurrence of TB and was found to be a protective factor, which is in contrast to the results of a previous study of Turks (Oral et al, 2006). High IL-6 expression levels are thought to regulate the immune balance of Th1/Th2 and prevent M. tuberculosis infections from developing into TB because of immune imbalance.…”

“…Individual susceptibility to PTB is determined by the host genome. Among the numerous cytokines, 2 candidate genes, interleukin (IL) genes IL-6 and IL-10, have been examined in recent studies (Jang et al, 2004;Amirzargar et al, 2006;Oral et al, 2006). The frequencies of the IL-6 -174 and IL-10 -1082, -819, and -592 genotypes were found to be significantly higher among PTB patients (Amirzargar et al, 2006;Oral et al, 2006).…”

“…Among the numerous cytokines, 2 candidate genes, interleukin (IL) genes IL-6 and IL-10, have been examined in recent studies (Jang et al, 2004;Amirzargar et al, 2006;Oral et al, 2006). The frequencies of the IL-6 -174 and IL-10 -1082, -819, and -592 genotypes were found to be significantly higher among PTB patients (Amirzargar et al, 2006;Oral et al, 2006). IL-6 and IL-10 are secreted by Toll-like receptor 2-expressing cells in response to the presence of M. tuberculosis early in infection and are involved in anti-tuberculosis immunity in the body (Jang et al, 2004).…”

Comparison of Genetic Polymorphisms of TNF-α and IL-10 Genes Between Tuberculosis Patients and Healthy Blood Donors

“…The study of cytokine gene polymorphisms is a helpful tool to predict the genetic susceptibility to diseases in special communities. Polymorphism in cytokine genes are known to influence cytokine levels and may also be associated with susceptibility/resistance to tuberculosis or outcome and clinical forms of this disease (9)(10)(11)(12)(13). The pattern of cytokine gene polymorphisms is different in various populations (14).…”