Interleukin‐10 (IL‐10) genotypes in inflammatory bowel disease

Abstract

Interleukin-10 (IL-10) is an anti-inflammatory cytokine. Its production in humans is under genetic control, and genotype defines high or low producers of this cytokine. This study addresses the hypothesis that idiopathic inflammatory bowel disease (IBD) patients are more likely to have the low IL-10 producer genotype and phenotype. DNA was extracted from blood cells of patients with Crohn's disease (CD) or with ulcerative colitis (UC) for IL-10 genotyping. The frequency of the high IL-10 producer allele (-1082*G) was decreased in the whole IBD group (41% vs. 51%, P = 0.03) and in the UC patients compared with normal controls (37% vs. 51%; P = 0.04). Hence, there appears to be an association between the IL-10 genotypes and IBD. This suggests that individuals genetically predisposed to produce less IL-10 are at a higher risk of developing IBD, in particular, UC.

Gender-specific association between −1082 IL-10 promoter polymorphism and longevity

“…In fact, the −1082A carriers (ie IL-10 low producers) have been shown to be more likely to develop inflammatory diseases (or to be affected by more severe clinical patterns), such as rheumatoid arthritis and inflammatory bowel diseases. [35][36][37] The positive significant association between −1082 IL-10 polymorphism and longevity was observed in centenarian men but not in women, in accord with previous observations on polymorphisms in Tyrosine Hydroxylase gene 38 and mtDNA haplogroups. 39 On the other hand, haemochromatosis 40 and interferon(IFN)-␥ 41 gene polymorphisms have been shown to be associated with longevity in women, but not in men.…”

Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance

“…24,25 The IL10 gene has been implicated in the response to a number of diseases such as hepatitis B, pulmonary tuberculosis, herpes zoster, cutaneous malignant melanoma, hepatocellular carcinoma fibrosis, gastric carcinoma, squamous cell carcinoma, inflammatory bowel disease, and HIV. [26][27][28][29][30][31][32][33][34] The genetic neighbors of IL10 consisting of IL19, IL20, and IL24 also modulate the TH1 and TH2 response, suggesting that these recently discovered loci could also be important in HCV clearance. 35 A number of studies have examined the IL10 promoter region SNPs and their associations with HCV susceptibility as well as resistance to antiviral therapy.…”

Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasis

“…[12][13][14][15] The relevance of IL-10 gene polymorphisms has been demonstrated by their involvement in determining the susceptibility and/or the severity for a number of immune inflammatory diseases including rheumatoid arthritis, 16 inflammatory bowel disease, 17 systemic lupus erythematosus 18 and severe asthma. 19 We demonstrated previously that IL-10 promoter polymorphisms influence clinical course of plaque-type psoriasis.…”