Interleukin-10 Promoter 1082/−819/−592 Polymorphisms are Associated with Asthma Susceptibility in Asians and Atopic Asthma: A Meta-Analysis

Zheng, Xianrui; Guan, Weijun; Chen, Mao; Chen, Huifang; Ding, Hong; Zheng, Jinping; Hu, Tingting; Luo, Minhong; Huang, Yanhui; Chen, Qing

doi:10.1007/s00408-013-9519-8

Cited by 32 publications

(40 citation statements)

References 30 publications

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“…The results of previous meta-analyses exploring the association between these three polymorphisms in the IL-10 promoter region and asthma susceptibility are not consistent (Nie et al, 2012;Hyun et al, 2013;Zheng et al, 2014). Both Nie et al (2012) and Zheng et al (2014) concluded that the IL-10 -1082G/A and -592C/A (and not the -819C/ T) polymorphisms were significantly associated with asthma susceptibility.…”

Section: Introductionmentioning

confidence: 91%

“…Both Nie et al (2012) and Zheng et al (2014) concluded that the IL-10 -1082G/A and -592C/A (and not the -819C/ T) polymorphisms were significantly associated with asthma susceptibility. However, the former did not analyze these relationships in children, and the latter reported no associations between these polymorphisms and pediatric asthma in an Asian population, despite stratifying the data by age.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility

Zy¹,

Bj²,

Wan³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The results of previous epidemiological studies exploring the relationship between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to pediatric asthma are not consistent. Therefore, we have performed a systematic review and meta-analysis to provide a more convincing conclusion. Odds ratios (OR) with their 95% confidence intervals (CIs) were used to evaluate the strength of association between the IL-10 promoter polymorphisms and susceptibility to pediatric asthma. Publication bias was examined by Begg's funnel plots and the Egger test. A detailed literature search based on stringent parameters yielded sixteen relevant studies, comprising 2494 cases and 2160 controls. The overall population showed no significant association between the IL-10 -1082G/A polymorphism and pediatric asthma risk in any of the genetic models and atopic status subgroups. However, there was no evidence of a significant association between the other two polymorphisms (-819C/ T and -592C/A) and pediatric asthma in our study. No significant publication bias was observed in this meta-analysis. The results of this study indicate that the IL-10 -1082G/A polymorphism might be a risk factor for asthma in children. However, because of the small sample size included in the subgroup analyses, the results should be interpreted with caution.

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Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility

Zy¹,

Bj²,

Wan³

et al. 2016

Genet. Mol. Res.

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“…Three dimorphic polymorphisms in the promoter region, at positions -1082 A/G (rs1800896), -819 T/C (rs1800871) and -592 A/C (rs1800872) have been identified in many diseases [12][13][14][15][16][17]. According to several previous studies, altered genetic make-up appears to be responsible with modulated levels of IL-10 [18,19].…”

Section: Introductionmentioning

confidence: 99%

Association of IL-10 GTC haplotype with serum level and HPV infection in the development of cervical carcinoma

et al. 2014

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“…Previous studies have reported that IL-10-1082A/G polymorphism was associated with various diseases such as Graves' disease, liver cirrhosis, ischemic stroke, deep venous thrombosis, and atopic asthma (Jin et al, 2014;Tang et al, 2014;Zheng et al, 2014;Guo et al, 2015;Liang et al, 2015). Zheng et al (2014) conducted a meta-analysis with 4,716 asthmatic patients and 5,093 controls, and reported that IL-10 promoter-1028A/G polymorphism was associated with susceptibility to asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Zheng et al (2014) conducted a meta-analysis with 4,716 asthmatic patients and 5,093 controls, and reported that IL-10 promoter-1028A/G polymorphism was associated with susceptibility to asthma. Tang et al (2014) conducted a case-control study on patients with deep venous thrombosis, and reported that IL-10-1082A/G polymorphism was correlated with the development of deep venous thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population

2016

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ABSTRACT. We conducted a case-control study to investigate the association between IL-10-G1082A (rs1800896) polymorphism and the development of coronary artery disease (CAD) in the Chinese population. We recruited 295 CAD patients and 355 healthy controls from the Fifth Affiliated Hospital of Zhengzhou University between April 2012 and December 2014. Subjects were genotyped for IL-10-G1082A polymorphisms by using polymerase chain reaction-restriction fragment length polymorphism. We observed significant differences in the genotype frequencies of GG, AG, and AA between CAD patients and controls (c 2 = 17.38, P < 0.001). Multivariate logistic regression analyses revealed that individuals with the AA genotype at IL-10-1082A/G was associated with increased risk for CAD as compared to those with the GG genotype (OR = 2.96, 95%CI = 1.70-5.23, P < 0.001). Our results indicated that IL-10 -1082A/G polymorphism was associated with susceptibility to CAD in both dominant (OR = 1.59, 95%CI = 1.15-2.20, P = 0.004) and recessive (OR = 2.58, 95%CI = 1.53-4.45, P < 0.001) models. In conclusion, our study suggests that IL-10-1082A/G polymorphism is associated with an increased risk for CAD.

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Interleukin-10 Promoter 1082/−819/−592 Polymorphisms are Associated with Asthma Susceptibility in Asians and Atopic Asthma: A Meta-Analysis

Abstract: IL-10 promoter -1028A/G, -592A/C polymorphisms and their haplotypes, but not -819T/C polymorphism, correlate with asthma susceptibility.

Cited by 32 publications

References 30 publications

Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility

Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility

Association of IL-10 GTC haplotype with serum level and HPV infection in the development of cervical carcinoma

Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population

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