Interleukin-12 and interleukin-16 in periodontal disease

Tsai, I-Hsuan; Tsai, Chi‐Cheng; Ho, Ya-Ping; Ho, Kuen‐Yao; Wu, Yimin; Hung, Chun-Cheng

doi:10.1016/j.cyto.2005.02.007

Cited by 51 publications

(59 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been proposed that an 9 increase in IL-12 production could be an event associated with the inhibition of pro inflammatory cytokines, such as TNF-α (47). IL-12 is considered a link between innate and adaptive immunity (48,49), and may be related to the pathogenesis of periodontal disease (50)(51)(52). Another interesting observation in the present study is that the production of the anti-inflammatory cytokine IL-10 was increased in response to LDD, possibly potentiating its beneficial effects to the host (53).…”

Section: Actinomycetemcomitans Lps (42) In Other Experimental Systemsupporting

confidence: 51%

Effects of low-dose doxycycline on cytokine secretion in human monocytes stimulated with Aggregatibacter actinomycetemcomitans

et al. 2011

View full text Add to dashboard Cite

Doxycycline is an antibiotic used in the treatment of a variety of inflammatory conditions, including periodontitis. Apart from its antimicrobial properties, this drug also has independent antiinflammatory effects at sub-antimicrobial doses. The present study aimed to investigate the effects of low-doses of doxycycline (LDD) on cytokine production by human monocytic cells challenged with the periodontal pathogen Aggregatibacter actinomycetemcomitans, for up to 6h. The simultaneous regulation of 12 cytokines were measured by a Human Cytokine Array Kit. To validate the array findings, selected cytokines were also measured by enzyme-linked immunosorbant assay (ELISA). A. actinomycetemcomitans stimulated the production of tumor necrosis factor (TNF)-, interleukin (IL)-1 , IL-1 , IL-6 and IL-8 by the cells after 6h of challenge, and doxycycline significantly inhibited this effect. The kinetics of this regulation demonstrated an early (within 2h) and significant (P<0.05) inhibition of pro-inflammatory cytokines, with a mild (0.5-fold) up-regulation of the anti-inflammatory cytokine IL-10. The results indicate that LDD acts as an anti-inflammatory agent in human monocytic cells stimulated with A. actinomycetemcomitans. This model provides clear evidence that some of the clinically proven benefits of LDD may be related to its ability to regulate inflammatory mediator release by monocytic cells. This property may contribute to the clinically proven benefits of this antibiotic as an adjunctive treatment for periodontitis.

show abstract

Section: Actinomycetemcomitans Lps (42) In Other Experimental Systemsupporting

confidence: 51%

Effects of low-dose doxycycline on cytokine secretion in human monocytes stimulated with Aggregatibacter actinomycetemcomitans

et al. 2011

View full text Add to dashboard Cite

show abstract

“…in 2005 (8), after carrying out a case-control study in which they analyzed interleukins 12 and 16, found that IL-16 was higher in the crevicular fluid of healthy patients, followed by those with gingivitis and periodontitis. They also found that the total concentration of IL-12 was significantly higher in the crevicular fluid of patients affected by gingivitis and periodontitis than in healthy patients.…”

Section: Resultsmentioning

confidence: 99%

Salivary and crevicular fluid interleukins in gingivitis

Boronat-Catalá¹,

Catalá-Pizarro

2014

J Clin Exp Dent

View full text Add to dashboard Cite

Introduction: Gingivitis is a frequent inflammatory process of the gum tissue that is mainly caused by the accumulation of plaque. The immune response against inflammatory processes is regulated in part by cytokines. Aims: Given that a continuous inflammation exists in gingivitis, it would be logical to assume that the interleukins will be altered locally in those patients. Therefore, the aim of this review was to check whether there is evidence that the interleukins can be used as diagnostic markers of inflammation levels in patients with gingivitis. Materials and Methods: A bibliographical search was undertaken using the key words interleukin and gingivitis in Pubmed, Cochrane, Scopus and Embase. Only those articles published over the last 10 years that were systematic reviews, case-controls or cohort studies in which interleukins in saliva and/or crevicular fluid was investigated in patients with gingivitis were selected. Results: Finally 15 articles were selected, all of them being case-control studies. The interleukins analyzed in the reviewed articles were: IL-1β, IL-8, IL-18, IL-11, IL-12, TNFα, IL-4, IL-17, IL-1α and IL-6. The most commonly studied interleukin is IL-1β and most authors agree that it is higher in the saliva and/or crevicular fluid of patients with gingivitis. Therefore, it could be used as a diagnostic marker of the degree of inflammation in gingivitis. Moreover, as far as the other interleukins studied are concerned, there is no clear consensus among the authors. Conclusion: There is sufficient evidence to suggest that IL-1β in saliva and/or crevicular fluid can be used as a marker of the degree of inflammation in gingivitis. Key words:Interleukins, gingivitis, saliva, crevicular fluid.

show abstract

“…Aunque la mayoría de los estudios clínicos publicados muestran la disminución de la concentración de citoquinas en surco periodontal después del tratamiento periodontal no quirúrgico (RAR), especialmente en cuanto a la reducción de la concentración de IL-1ß (27,29), nuestros resultados se aproximan más a los obtenidos por Yoshinari y cols. (30), en un estudio donde se investigó la relación entre los cambios clíni-cos e IL-1ß después de la terapia periodontal convencional con RAR en pacientes con periodontitis cróni-ca, observándose clara mejoría de los índices clínicos y ligero aumento de la concentración de IL-1ß.…”

Section: Discussionunclassified