Interleukin-12, interleukin-23, and psoriasis: Current prospects

Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review

“…IL-23 is known to be a regulator of cellular immune responses involved autoimmune diseases such as IBD (McGovern & Powrie, 2007), psoriasis (Torti & Feldman, 2007) and rheumatoid arthritis (RA; Kim et al 2007). In humans, IL-23 is over-expressed in clinical samples of psoriasis (Lee et al 2004), CD (Schmidt et al 2005) and ankylosing spondylitis (Wang et al 2009).…”

Psoriasis as a disease associated with the immune system disorders

“…Probably, it also is responsible for the formation of inflammatory infiltrates of various epidermal immune cells, promotes epidermal acanthosis [53] and causes the release of TNF-α [44]. In recent years, an important role in the pathogenesis of psoriasis has been attributed to the interrelation between Th17 cells and IL-23 [49].…”

The Association Between Psoriasis and Cardiovascular Diseases

“…IL-12 supports growth and differentiation of naive T-cells into Th1 and cytotoxic T-cells. IL-23rd motivates endurance and proliferation of a unique set of T-cells, named Th17 cells (10,11). IL-12 is considered to supply a association between inflammation and Th1-type cytokine production in coronary atherosclerosis (12).…”