Interleukin-12 is involved in the enhancement of human natural killer cell activity by<i>Lactobacillus casei</i>Shirota

Takeda, Kazuyoshi; Suzuki, Tomomi; Shimada, Satoru; Shida, Katsunori; Nanno, Msanobu; Okumura, Ko

doi:10.1111/j.1365-2249.2006.03165.x

Cited by 163 publications

(134 citation statements)

References 35 publications

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“…Therefore, we believe that the effect of 1073R-1 yoghurt is mainly dependent on the immunostimulatory polysaccharides produced from L. bulgaricus OLL1073R-1. However, the cell body of L. bulgaricus OLL1073R-1 may also contribute to the effect of this yoghurt because the cell body has been reported to exert host-mediated anti-tumour activity in mice (8) and some probiotics have been shown to enhance natural killer cell activity in elderly individuals (5,23,24) . With regard to natural killer cell activity, in the present study, we found a significant positive correlation between the promotion of natural killer cell activity and the total score for the 'eye/nose/throat' system, and these two parameters after intake were significantly higher in the 1073R-1 yoghurt group than in the milk group.…”

Section: Discussionmentioning

confidence: 99%

Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented withLactobacillus delbrueckiissp.bulgaricusOLL1073R-1

Makino¹,

Ikegami²,

Kume³

et al. 2010

Br J Nutr

211

181

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Immune senescence potentially leads to an increased risk of infections. It is desirable to augment the immune system and protect against infections by daily consumption of immunostimulatory food. The present study evaluated whether the intake of yoghurt fermented with Lactobacillus delbrueckii ssp. bulgaricus (L. bulgaricus) OLL1073R-1 has an effect on resistance to the common cold. We conducted two independent studies, in which fifty-seven (median age 74·5 years) and eighty-five healthy elderly individuals (median age 67·7 years) were participants. In each study, the subjects were divided into two groups based on age and sex and instructed to eat 90 g yoghurt or drink 100 ml milk once per d over an 8-or 12-week period. A meta-analysis of the results of these two independent studies showed the risk of catching the common cold was about 2·6 times lower (OR 0·39; P¼ 0·019) in the yoghurt group than in the milk group and the increase of natural killer cell activity was significantly higher in the yoghurt group than in the milk group (P¼0·028). In addition, the quality of life score for the 'eye/nose/throat' system after intake was significantly higher in the yoghurt group than in the milk group and the improvement of the score was correlated with the promotion of natural killer cell activity. In conclusion, consumption of yoghurt fermented with L. bulgaricus OLL1073R-1 augmented natural killer cell activity and reduced the risk of catching the common cold in elderly individuals. The proportion and absolute number of individuals above the age of 65 years are steadily increasing in most countries, particularly in industrialised nations. It is recognised that elderly individuals suffer from not only common age-related illness, including atherosclerosis, Alzheimer's dementia, diabetes mellitus and osteoporosis, but more frequent and more severe infections than younger individuals. The reasons for this include epidemiological elements, immunosenescence and malnutrition, as well as a large number of age-associated physiological and anatomical alterations (1)

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Section: Discussionmentioning

confidence: 99%

Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented withLactobacillus delbrueckiissp.bulgaricusOLL1073R-1

Makino¹,

Ikegami²,

Kume³

et al. 2010

Br J Nutr

211

181

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“…It is known that probiotics can regulate the expression of phagocytosis receptors in the neutrophils of healthy individuals and enhance natural killer cell activity. 18,31 In the present study, beneficial impact of probiotic bacteria is well established by statistical significant reduction in plaque index (PI) and level of Streptococcus mutans in Group-B (Probiotic group) as compared to Group-A (Control group). 2, 3 The observed improvement in clinical status may be attributed to the reduced levels of cariogenic as well as periodontal pathogens and effective colonization of the probioti bacteria within the oral cavity.…”

Section: Discussionmentioning

confidence: 83%

Role of Probiotics on Oral Health - A Randomized, Double Blind, Placebo-Controlled Microbiological Study

Dhawan¹,

Dhawan²

2013

DENT

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The aim of this study was to investigate commercially available combined probiotic formulation for its effect on plaque, gingivitis and salivary Streptococcus mutans levels in subjects with chronic gingivitis. A total of 36 subjects were finally enrolled in a double blind placebo controlled randomized trial. Selected subjects were randomly divided in two groups; Group A (Control group) with 17 subjects, receiving placebo tablets twice daily and Group B (Probiotic group) with 19 subjects receiving probiotic tablets twice daily. The study consisted of two 2 weeks periods, a two week intervention period (T1-T2) and a two week post treatment period (T2-T3). Clinical parameters and bacterial counts of salivary Streptococcus mutans, were evaluated at the baseline (T1), at the completion (T2) of medication and 2 weeks after medication (T3). On comparative evaluation between the two groups, results indicated that Group-B (Probiotic group) exhibited statistically significant reduction in Plaque Index, Gingival index and Streptococcus mutans level than Group-A (Control group) over the entire span of the study. Our results indicated that probiotic could be useful in the improvement/ maintainance of oral health.

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“…В конце периода наблюдения в группе, получавшей Bifidobacterium lactis BВ12, индекс SCORAD [первоначально равный 16 (7-25)] составил 0 (0-3,8), тогда как в группе, получавшей Lactobacillus GG, эта вели-чина равнялась 1 (0,1-8,7). Среди детей, получавших смесь без введения пробиотиков, индекс SCORAD соста-вил 13,4 (4,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)2). Таким образом, в данном исследо-вании показана не только эффективность пробиотиков для профилактики аллергии, но и более выраженное действие штамма Bifidobacterium lactis BВ12.…”

Section: обзор литературыunclassified

Commensal Microorganisms in Development of the Children Immune System and New Facilities of Probiotics Usage

Ильина¹

2014

Vopr. sovr. pediatr.

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Роль комменсальных микроорганизмов в формировании иммунной системы у детей, и новые возможности использования пробиотиков Возрастные аспекты формирования противоинфек-ционной защиты не только были и остаются одним из наиболее популярных предметов для научных иссле-дований, но и вызывают неизменный практический интерес у врачей-педиатров, поскольку число часто болеющих детей не имеет тенденции к уменьшению, а вопрос о возможности эффективного воздействия на эту проблему все еще остается открытым. Одна из сту-пеней, ведущих к расшифровке механизмов становления иммунитета, -это понимание связи между кишечной

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Interleukin-12 is involved in the enhancement of human natural killer cell activity byLactobacillus caseiShirota

Cited by 163 publications

References 35 publications

Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented withLactobacillus delbrueckiissp.bulgaricusOLL1073R-1

Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented withLactobacillus delbrueckiissp.bulgaricusOLL1073R-1

Role of Probiotics on Oral Health - A Randomized, Double Blind, Placebo-Controlled Microbiological Study

Commensal Microorganisms in Development of the Children Immune System and New Facilities of Probiotics Usage

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