Interleukin-13 +2044 G/A and +1923C/T polymorphisms are associated with asthma susceptibility in Asians

Mei, Quanhui; Qu, Jingjing

doi:10.1097/md.0000000000009203

Cited by 12 publications

(11 citation statements)

References 39 publications

(42 reference statements)

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“…In line with these findings, we presume IL-13 +2044 A/G and IL-4 -590 C/T polymorphisms maybe potential susceptible predictor for pediatric asthma. However, some studies showed that IL-13 -1112C/T and +1923C/T polymorphisms were correlated with increased risk of asthma in children, [ 68 , 69 , 71 ] which is different from our results. The reasons may be as follows: on the one hand, a significantly increased risk between IL-13 -1112C/T and asthma risk was observed by Liu et al [ 68 ] in overall populations, but not in Asians or Chinese.…”

Section: Discussioncontrasting

confidence: 99%

“…[ 67 ] Our results demonstrated that IL-13 +2044G/A and IL-4 -590C/T polymorphisms were associated with asthma risk in total populations and Chinese, while IL-13 -1112C/T, +1923C/T polymorphisms were not associated with the risk of childhood asthma in any models. These results are partially consistent with the previous meta-analyses: Liu et al [ 68 ] and Mei and Qu [ 69 ] found that IL-13 +2044A/G polymorphism was significantly associated with asthma risk in Asian children; Zhang et al [ 70 ] found that a strong association between the IL-4 - 590 C/T polymorphism and the risk of childhood asthma; a meta-analysis showed that IL-4 -590 C/T polymorphism was associated with asthma risk among Chinese children. In line with these findings, we presume IL-13 +2044 A/G and IL-4 -590 C/T polymorphisms maybe potential susceptible predictor for pediatric asthma.…”

Section: Discussionsupporting

confidence: 93%

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Asthma susceptible genes in children

et al. 2020

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 93%

Asthma susceptible genes in children

et al. 2020

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“…In line with these ndings, we presume IL-13 + 2044 A/G and IL-4 -590 C/ T polymorphism maybe risk factors in pediatric asthma. However, some studies has shown that IL-13 -1112C/T and IL-13 + 1923C/T variant were correlated with increased risk of asthma in children 58,59,61 , which is different from our results. The reasons may be the following: a signi cantly increased risk between IL-13 -1112C/T and asthma risk was observed by Liu et al 58 in overall populations, but not in Asians.…”

Section: Sensitivity Analysis and Publication Biascontrasting

confidence: 99%

“…Our results demonstrated that IL-13 + 2044G/A and IL-4 -590C/T polymorphism were associated with asthma risk in total populations and Asians, IL-13 -1112C/T and IL-13 + 1923C/T polymorphism were not associated with the risk of childhood asthma in any of the models. These results are partially consistent with the previous meta-analyses : Liu et al 58 and Mei et al 59 found that IL-13 + 2044A/G polymorphism was signi cantly associated with asthma risk in Asian children; Zhang et al 60 found that a strong association between the IL-4 -590 C/ T polymorphism and the risk of childhood asthma; a meta-analysis showed that IL-4 -590 C/ T polymorphism was associated with asthma risk among Chinese children. In line with these ndings, we presume IL-13 + 2044 A/G and IL-4 -590 C/ T polymorphism maybe risk factors in pediatric asthma.…”

Section: Sensitivity Analysis and Publication Biassupporting

confidence: 93%

Asthma susceptible genes in children: A meta-analysis

Ruan

Shi

Zhang

et al. 2020

Preprint

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Background: During the last decade, a number of studies have evaluated the potential association between some genetic polymorphisms and childhood asthma risk, however, the results of published studies appeared conflicts. The aim of the present study was to investigate association between genetic polymorphisms and pediatric asthma. Methods: Relevant studies were searched in PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang and Weipu database. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to access the strength of the associations. Results: 45 case-control studies were finally included in this meta-analysis. Eighteen SNPs were identified. Ten polymorphisms were found to be associated with asthma risk: IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4, ORMDL3 rs7216389, VDR ApaⅠ, VDR FokⅠ, VDR BsmⅠ. After subgroup analysis, IL-13 +2044G/A, ADAM33 T2, ADAM33 T1, VDR ApaⅠ, VDR BsmⅠ polymorphisms were associated with increased risk of asthma among Asian populations. IL-4 -590C/T polymorphisms may be related to asthma risk in Chinese children.Conclusions: This meta-analysis found that IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4, ORMDL3 rs7216389, VDR ApaⅠ, VDR FokⅠ and VDR BsmⅠ polymorphisms might be risk factors for childhood asthma. Further study with large population and more ethnicities is needed to estimate the associations.

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“…Numerous genetic and molecular studies have been carried out in the eld of asthma in both the children and in adults previously [50][51][52][53][54][55][56][57][58][59][60]. Among genetic studies, exome/NG sequencing studies has been documented throughout the global populations [61,62].…”

Section: Resultsmentioning

confidence: 99%

Next Generation Exome Sequencing of paediatric Asthma Identifies Rare and Novel Variants in Candidate Genes

Bogari

Amin

Rayes

et al. 2020

Preprint

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Background: Multiple genes have been implicated to have a role in asthma predisposition by association studies. Paediatric patients often manifest more extensive disease and a particularly severe disease course. It is likely that genetic predisposition could play a more substantial role in this group. This study aims to identify the spectrum of rare and novel variation in known paediatric asthma susceptibility genes using whole exome sequencing-analysis in nine individual cases of childhood onset allergic asthma. Data were processed through an analytical pipeline to align sequence reads, conduct quality checks, identify and annotate variants where patient sequence differed from the reference sequence. Results: DNA samples from the nine children with a history of bronchial asthma diagnosis underwent targeted exome capture and sequencing. For each patient, the entire complement of rare variation within strongly associated candidate genes was catalogued. The analysis showed 21 variants in the subjects, 13 had been previously identified and 8 were novel. Also, amongst of which, nineteen were non-synonymous and 2 were nonsense. With regard to the novel variants, the 2 non-synonymous variants in the PRKG1 gene (PRKG1: p.C519W and PRKG1: p.G520W) were presented in 4 cases, and a non-synonymous variant in the MAVS gene (MAVS: p.A45V) was identified in 3 cases. The variants we found in this study will enrich the variants spectrum and build up the database in the Saudi population. Novel eight variants were identified in the study which provides more evidence in the genetic susceptibility in asthma among Saudi children.Conclusion: Screening a cohort of Saudi children for molecular identification of polymorphisms associated with allergic asthmatic response. These, together with the clinical phenotypes, revealed genetic determinants for paediatric asthma and also we compared to the similar previous reports. Providing a genetic screening map for the molecular genetic determinants of allergic disease in Saudi children, with the goal of reducing the impact of chronic diseases on the health and the economy. We belief that the advanced specified statistical filtration/annotation programs used in this study succeeded to release such results in preliminary study, exploring the genetic map of that disease in Saudi children.

show abstract

Interleukin-13 +2044 G/A and +1923C/T polymorphisms are associated with asthma susceptibility in Asians

Cited by 12 publications

References 39 publications

Asthma susceptible genes in children

Asthma susceptible genes in children

Asthma susceptible genes in children: A meta-analysis

Next Generation Exome Sequencing of paediatric Asthma Identifies Rare and Novel Variants in Candidate Genes

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