Interleukin 13 expression in the primary breast cancer tumor tissue

Abstract

131 Ab stra ctIn tro duc tion: The aim of this stu dy was to in ves ti ga te the pre sen ce and the expres sion le ve ls of the in ter leu kin 13 (IL-13) in the pri ma ry brea st cancer tu mour tis sue in re la tion to the un chan ged brea st tis sue in the sa me pa tien ts and to the brea st tis sue in the pa tien ts wi th be ni gn brea st di sea se, and to in ves ti ga te the cor re la tion be tween the IL-13 expres sion le ve ls and the pat ho his to lo gi cal fac to rs, and be tween IL-13 expres sion and es tro ge ns and pro ges te ro ne re cep tor sta tus. Ma te ria ls and met ho ds: 50 pa tien ts wi th in va si ve duc tal brea st can cer and 20 pa tien ts wi th be ni gn brea st di sea ses we re in clu ded in this prospec ti ve ca se-con trol stu dy. The three-step im mu no his toc he mi cal stai ni ng was used for tes ti ng the le ve ls of IL-13 expres sion and hor mo ne re cep tor sta tus. Re sul ts: IL-13 was pre se nt in brea st can cer tu mour tis sue, and in the sur roun di ng un chan ged tis sue in the sa me pa tien ts, and in brea st tis sue in patien ts wi th be ni gn brea st di sea se. The expres sion of IL-13 was sig ni fi can tly hig her in brea st can cer tu mour com pa red wi th sur roun di ng tis sue (P < 0.05) of the sa me, lymph no de-po si ti ve pa tien ts. In ad di tion, IL-13 expres sion was sig ni fi can tly hig her in brea st can cer tu mour com pa red wi th brea st tis sue in pa tien ts wi th be ni gn brea st di sea ses (P < 0.01). The re was sig ni fi ca nt cor re la tion be tween IL-13 expres sion and tu mour si ze in pa tien ts wi th lymph node-ne ga ti ve brea st can cer (r = 0.405, P = 0.050). The re was no sig ni fi ca nt cor re la tion be tween IL-13 expres sion and the ot her pat ho his tolo gi cal fac to rs, and no sig ni fi ca nt cor re la tion be tween IL-13 expres sion and the lymph no de sta tus. Con clu sion: Obtai ned re sul ts sug ge st pos sib le in vol ve me nt of IL-13 in brea st car ci no ge ne sis. Key wor ds: in ter leu kin 13; brea st can cer; brea st tis sue; beni gn brea st di sea se Re cei ved: No vem ber

Association of –607 C/A Polymorphism of IL-18 Gene (rs1946518) with Breast Cancer Risk in Zahedan, Southeast Iran

“…It has dual effect on cancer; ex part it has anti-tumor activities that are mediated by increasing of NK cell activity and induction of apoptosis in tumor cells (Srabovic et al, 2011). Besides, IL-18 has also been found to promote tumor progression (Park et al, 2007).…”

“…Increased levels of IL-18 have been detected in various cancers. Besides, elevated IL-18 expression has been associated with tumor growth and metastasis in breast cancer (Gunel et al, 2002;Srabovic et al, 2011).…”

Targeting IL4/IL4R for the treatment of epithelial cancer metastasis

“…IL13 is upregulated in primary breast cancer tissue [72] and in the peripheral blood of patients with pancreatic, esophageal, and gastric cancer [73]. While studies focusing on the implications of IL13 signaling in epithelial cancer cells are limited, it is known to have both pro-tumorigenic and pro-metastatic roles as we have previously reviewed [2].…”

Cytokine Stimulation of Epithelial Cancer Cells: The Similar and Divergent Functions of IL-4 and IL-13

“…IL13 can signal through type II IL4R (IL4Rα and IL13Rα1) or through IL13Rα2, once believed to serve only as a decoy receptor. Elevated levels of IL13 were detected in primary breast cancer tumor tissue (24) and in the peripheral blood of 131 other cancer patients (pancreatic, esophageal and gastric) when compared to healthy controls (25). Recent studies by Formentini, et al and Barderas, et al suggested possible roles for IL13 and its receptors IL13Rα1 and IL13Rα2 in colorectal cancer (11, 26).…”