2008
DOI: 10.1016/j.vaccine.2008.03.088
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Interleukin-15 enhance DNA vaccine elicited mucosal and systemic immunity against foot and mouth disease virus

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Cited by 42 publications
(28 citation statements)
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“…It has significant potential as a vaccine adjuvant for cancer therapy because of its ability to promote the expansion and survival of CD8 ϩ T cells (5,34). In this study, the immune response in vMyx-IL-15-tdTrinfected animals was elevated in terms of cellular infiltrations (especially heterophils and macrophages) into areas of virus inoculation as observed by histology.…”
Section: Myxoma Virus (Myxv) Is a Poxvirus From The Leporipoxvirus Gementioning
confidence: 62%
“…It has significant potential as a vaccine adjuvant for cancer therapy because of its ability to promote the expansion and survival of CD8 ϩ T cells (5,34). In this study, the immune response in vMyx-IL-15-tdTrinfected animals was elevated in terms of cellular infiltrations (especially heterophils and macrophages) into areas of virus inoculation as observed by histology.…”
Section: Myxoma Virus (Myxv) Is a Poxvirus From The Leporipoxvirus Gementioning
confidence: 62%
“…High levels of sIgA were also observed in the mucosa of IL-1 family cytokine-treated mice. However, IL-12 and IL-15 have been reported to promote systemic and mucosal immunity to intramucosally coadministered protein Ags (8,45), although more frequent immunization was required to produce adjuvant activity. The apparent discrepancy concerning the adjuvant activity of IL-12 and IL-15 in this study and previous reports may be due to differences in immunization regimens and vaccine doses.…”
Section: Discussionmentioning
confidence: 99%
“…These advantages make it an ideal candidate for the nasal delivery of vaccines (44). Recently, chitosan has been extensively studied as a mucosal gene carrier, and chitosan-DNA nanoparticles have proved effective in inducing mucosal and systemic immune responses in several experiments (46,49,52). However, chitosan as a pneumococcal DNA vaccine carrier has not been reported.…”
mentioning
confidence: 99%