Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93

Huang, Jinling; Lee, Hae-youn; Zhao, Xiaohong; Han, Jin-Yi; Su, Yang; Sun, Qinli; Shao, Jing; Ge, Jiwan; Zhao, Yuxi; Bai, Xue; He, Yi; Wang, Xinquan; Wang, Xiaohu; Dong, Chen

doi:10.1016/j.immuni.2021.03.018

Cited by 70 publications

(58 citation statements)

References 52 publications

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“…Among them, IL-17A is a proinflammatory cytokine participating in the primary responses to fungi and bacterial infections, followed by its close homolog IL-17F (15,16). Novel research demonstrated that intestinal epithelial cell-derived IL-17D, as the least studied member, serves as a critical factor in regulating group 3 innate lymphoid cell (ILC3) functions and intestinal homeostasis by binding the receptor CD93 (17). These results further expand the biological role of the IL-17 family.…”

Section: Il-17 Family and Receptorsmentioning

confidence: 99%

Role of Interleukin-17 in Acute Pancreatitis

Chen

Liu

et al. 2021

Front. Immunol.

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Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by systemic manifestations that are generally associated with a poor prognosis. Many cytokines contribute to pancreatic tissue damage and cause systemic injury. Interleukin-17 (IL-17) is a cytokine that may play a vital role in AP. Specifically, IL-17 has important effects on the immune response and causes interactions between different inflammatory mediators in the AP-related microenvironment. In this literature review, we will discuss the existing academic understanding of IL-17 and the impacts of IL-17 in different cells (especially in acinar cells and immune system cells) in AP pathogenesis. The clinical significance and potential mechanisms of IL-17 on AP deterioration are emphasized. The evidence suggests that inhibiting the IL-17 cytokine family could alleviate the pathogenic process of AP, and we highlight therapeutic strategies that directly or indirectly target IL-17 cytokines in acute pancreatitis.

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Section: Il-17 Family and Receptorsmentioning

confidence: 99%

Role of Interleukin-17 in Acute Pancreatitis

Chen

Liu

et al. 2021

Front. Immunol.

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“… The IL-17 family, its receptors and the downstream signaling pathways ( 1 , 3 , 4 , 6 ). The IL-17 family consists of six family members.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-17 family members in health and disease

Chung

Iwakura

2021

International Immunology

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The interleukin-17 (IL-17) family consists of six family members (IL-17A–IL-17F) and all the corresponding receptors have been identified recently. This family is mainly involved in the host defense mechanisms against bacteria, fungi and helminth infection by inducing cytokines and chemokines, recruiting neutrophils, inducing anti-microbial proteins and modifying T-helper cell differentiation. IL-17A and some other family cytokines are also involved in the development of psoriasis, psoriatic arthritis and ankylosing spondylitis by inducing inflammatory cytokines and chemokines, and antibodies against IL-17A as well as the receptor IL-17RA are being successfully used for the treatment of these diseases. Involvement in the development of inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and tumors has also been suggested in animal disease models. In this review, we will briefly review the mechanisms by which IL-17 cytokines are involved in the development of these diseases and discuss possible treatment of inflammatory diseases by targeting IL-17 family members.

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“…In addition, IL-17C uses IL-17RA and IL-17RE to transduce signal (42). Recently, CD93 has been identified as a functional receptor that recognizes IL-17D, but whether CD93 pairs with other receptors to transduce signals from IL-17D requires further investigation (28). Both IL-17B and IL-25 signal through a heterodimeric receptor of IL-17RA and IL-17RB (37,39).…”

Section: Il-25 and Its Signal Transductionmentioning

confidence: 99%

“…Among IL-17 family cytokines, IL-17D is a less studied cytokine, which has been found to induce the expression of pro-inflammatory cytokines including IL-6 and IL-8 in endothelial cells (27). A recent study has identified CD93 as the IL-17D receptor expressed in group 3 innate lymphoid cells (ILC3s) whereas IL-17D exerts anti-inflammatory effects in DSS-induced colitis through inducing IL-22 production by ILC3s (28).…”

Section: Introductionmentioning

confidence: 99%

Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis

et al. 2021

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Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases. Compared with other IL-17 cytokine family members, IL-25 has relatively low sequence similarity to IL-17A and exhibits a distinct function from other IL-17 cytokines. IL-25 binds to its receptor composed of IL-17 receptor A (IL-17RA) and IL-17 receptor B (IL-17RB) for signal transduction. IL-25 has been implicated as a type 2 cytokine and can induce the production of IL-4, IL-5 and IL-13, which in turn inhibits the differentiation of T helper (Th) 17. In addition to its anti-inflammatory properties, IL-25 also exhibits a pro-inflammatory effect in the pathogenesis of Th17-dominated diseases. Here, we review recent advances in the roles of IL-25 in the pathogenesis of inflammation and autoimmune diseases.

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Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93

Cited by 70 publications

References 52 publications

Role of Interleukin-17 in Acute Pancreatitis

Role of Interleukin-17 in Acute Pancreatitis

Interleukin-17 family members in health and disease

Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis

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