Interleukin-18 correlates with interleukin-4 but not interferon-gamma production in the lymphocyte cultures of atopic dermatitis patients after staphylococcal enterotoxin B stimulation

Suwarsa, Oki; Adi, Sudigdo; Idjradinata, Ponpon; Sutedja, Endang; Avriyanti, Erda; Asfara, Adlina; Gunawan, Hendra

doi:10.12932/ap0787

Cited by 2 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AD skin lesions have many skin-infiltrating cells, including CD8 + T cells, which can release granzyme B to cleave pro-IL-18, thus triggering inflammation activation ( 36 ). Additionally, S. aureus , particularly important in the pathogenesis of AD, can secrete staphylococcal enterotoxin B, which promotes IL-18 production ( 123 ). Konishi et al.…”

Section: Il-18 and Il-18bp In Inflammatory Dermatological Diseasesmentioning

confidence: 99%

Interleukin-18 and IL-18BP in inflammatory dermatological diseases

Wang

Wang²,

Wen³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity. Moreover, IL-18 exerts an influential function in host innate and adaptive immunity, and IL-18BP has elevated levels of interferon-γ in diverse cells, suggesting that IL-18BP is a negative feedback inhibitor of IL-18-mediated immunity. Similar to IL-1β, the IL-18 cytokine is produced as an indolent precursor that requires further processing into an active cytokine by caspase-1 and mediating downstream signaling pathways through MyD88. IL-18 has been implicated to play a role in psoriasis, atopic dermatitis, rosacea, and bullous pemphigoid in human inflammatory skin diseases. Currently, IL-18BP is less explored in treating inflammatory skin diseases, while IL-18BP is being tested in clinical trials for other diseases. Thereby, IL-18BP is a prospective therapeutic target.

show abstract

Section: Il-18 and Il-18bp In Inflammatory Dermatological Diseasesmentioning

confidence: 99%

Interleukin-18 and IL-18BP in inflammatory dermatological diseases

Wang

Wang²,

Wen³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxins

Fang

et al. 2021

Animal Diseases

View full text Add to dashboard Cite

Staphylococcal superantigen (SAg) toxins are the most notable virulence factors associated with Staphylococcus aureus, which is a pathogen associated with serious community and hospital acquired infections in humans and various diseases in animals. Recently, SAg toxins have become a superfamily with 29 types, including staphylococcal enterotoxins (SEs) with emetic activity, SE-like toxins (SEls) that do not induce emesis in primate models or have yet not been tested, and toxic shock syndrome toxin-1 (TSST-1). SEs and SEls can be subdivided into classical types (SEA to SEE) and novel types (SEG to SElY, SE01, SE02, SEl26 and SEl27). The genes of SAg toxins are located in diverse accessory genetic elements and share certain structural and biological properties. SAg toxins are heat-stable proteins that exhibit pyrogenicity, superantigenicity and capacity to induce lethal hypersensitivity to endotoxin in humans and animals. They have multiple pathogenicities that can interfere with normal immune function of host, increase the chances of survival and transmission of pathogenic bacteria in host, consequently contribute to the occurrence and development of various infections, persistent infections or food poisoning. This review focuses on the following aspects of SAg toxins: (1) superfamily members of classic and novelty discovered staphylococcal SAgs; (2) diversity of gene locations and molecular structural characteristics; (3) biological characteristics and activities; (4) multi-pathogenicity of SAgs in animal and human diseases, including bovine mastitis, swine sepsis, abscesses and skin edema in pig, arthritis and septicemia in poultry, and nosocomial infections and food-borne diseases in humans.

show abstract

Interleukin-18 correlates with interleukin-4 but not interferon-gamma production in the lymphocyte cultures of atopic dermatitis patients after staphylococcal enterotoxin B stimulation

Abstract: Our results suggest that IL-18 is correlated with increased of IL-4 levels in SEB-stimulated AD lymphocyte cultures.

Cited by 2 publications

References 24 publications

Interleukin-18 and IL-18BP in inflammatory dermatological diseases

Interleukin-18 and IL-18BP in inflammatory dermatological diseases

Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxins

Contact Info

Product

Resources

About