Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation

Horiuchi, Hiroshi; Parajuli, Bijay; Komiya, Hiroyasu; Ogawa, Yuki; Jin, Shijie; Takahashi, Keita; Azuma, Yukio; Tanaka, Fumiaki; Suzumura, Akio; Takeuchi, Hideyuki

doi:10.3389/fimmu.2021.615898

Cited by 7 publications

(3 citation statements)

References 60 publications

(93 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In infected IL-20RA −/− mice, the serum IFN-γ level is elevated, and IFN-γ depletion increases viral loads in peripheral organs and EV-A71 lethality IL-20RA cytokiens can regulate cytokine expression [21][22][23]29]. As type I IFNs (IFN-α and IFN-β), IL-1β, and IL-6 have been shown to protect mice from EV-A71 infection [30][31][32], we monitored these cytokines and TNF-α using ELISA.…”

Section: Ev-a71 Infection Increases Mouse Serum and Brain Il-19 Levelsmentioning

confidence: 99%

Deficiency of IL-20 receptor subunit A decreases enterovirus A71 lethality of mice with enhanced M1 macrophage polarization and cytokine

Chen,

Hung,

Hsiao

et al. 2024

Preprint

View full text Add to dashboard Cite

Enterovirus A71 (EV-A71) can cause fatality in patients with increases of cytokines, IL-10, IL-12, and IFN-γ, which are mutually regulated. IFN-γ is induced and protects the host from EV-A71 in a murine infection model. IFN-γ and IL-10 promote the polarization of M1 and M2 macrophages, which produce IL-12 and IL-10, respectively. IL-10 suppresses IL-12, which enhances itself and IFN-γ. The IL-10 family cytokines, IL-19, IL-20, and IL-24, which signal through the two-subunit receptor complex with IL-20RA as one subunit, are therefore designated as IL-20RA cytokines. Previous in vitro T cell studies showed that IL-19 or IL-20 treatment suppresses IFN-γ and that IL-19 treatment enhances IL-10. In the present study of human plasma, IL-19 was detected in healthy controls, and EV-A71 infection increased IL-19 in patients. In the serum of mice, IL-20RA cytokines, but not IL-10, IL-12, and IFN-γ, were detected in mock-infected mice, and EV-A71 infection enhanced IL-19. Compared to wild-type mice, IL-20RA knockout mice were resistant to infection with reduced viral loads in peripheral organs, including the spleen. In infected mice, IL-20RA deficiency sequentially reduced IL-10, but increased IL-12 and IFN-γ, in the serum with T cells expressing IL-10 and macrophages expressing IL-12 and IFN-γ in the spleen. Notably, IL-20RA deficiency increased spleen M1 macrophages. In vitro study showed that treatment with IL-19 or IL-20, but not IL-24, increased IL-10 in CD4 T cells, but reduced IL-12 in macrophages. Our study is novel to show that IL-20RA cytokines affect virus infection, cytokines regulating macrophage polarization, and macrophage polarization.

show abstract

Section: Ev-a71 Infection Increases Mouse Serum and Brain Il-19 Levelsmentioning

confidence: 99%

Deficiency of IL-20 receptor subunit A decreases enterovirus A71 lethality of mice with enhanced M1 macrophage polarization and cytokine

Chen,

Hung,

Hsiao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…IL‐19 serves as a negative feedback regulator to limit the pro‐inflammatory response of macrophages and microglia in autocrine/paracrine manners. IL‐19 suppresses microglia/macrophage antigen presentation, T helper 17 cell expansion, and subsequent inflammation in the central nervous system, resulting in improvement in EAE 5 …”

Section: Figurementioning

confidence: 99%

“…In a recent study, we examined the pathological role of IL‐19 in EAE using IL‐19‐deficient mice 5 . IL‐19 deficiency markedly exacerbated EAE by promoting Th17 cell infiltration into the CNS.…”

Section: Figurementioning

confidence: 99%