Interleukin‐1α, interleukin‐6 and interleukin‐8 in cervico/vaginal secretion for screening of preterm birth in twin gestation

Wennerholm, Ulla‐Britt; Holm, Bente; Mattsby‐Baltzer, Inger; Nielsen, Thorkild F.; Platz-Christensen, Jens-Jörgen; Sundell, Gunilla; Hagberg, Henrik

doi:10.1034/j.1600-0412.1998.770507.x

Cited by 29 publications

(24 citation statements)

References 27 publications

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“…Hitti et al (2001) reported that lower levels of H 2 O 2 -producing lactobacilli were associated with increased IL-6 in women in preterm labor, but IL-8 was not significantly elevated in that group. This study did not observe a significant difference in IL-8 between the BV-positive and BV-negative groups, while previous studies did (Spandorfer et al, 2001;Wennerholm et al, 1998). A possible explanation for this could be differences in the study groups: HIV-seropositives were assessed in the current study, while HIV-seronegative women undergoing in vitro fertilization or with twin-pregnancies were assessed in the other two studies.…”

Section: Introductioncontrasting

confidence: 53%

“…Measurement of IL-8 may therefore be useful as a biomarker of inflammation at mucosal sites, including the female genital tract. For example, high vaginal IL-8 concentrations were associated also with amniotic fluid infections in women with preterm labor (Hitti et al, 2001) and in women with bacterial vaginosis (Spandorfer et al, 2001;Wennerholm et al, 1998). Vaginal IL-8 increases were noted also after sexual activity, after exposure to some microbicides and during menses (Al-Harthi et al, 2001;Fichorova, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Vaginal IL-8 levels are positively associated with Candida albicans and inversely with lactobacilli in HIV-infected women

Spear

Zariffard

Cohen

et al. 2008

Journal of Reproductive Immunology

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IL-8/ CXCL8 is induced during infections, but has not been reported for Candida albicans colonization of the female genital tract. Cervicovaginal lavage (CVL) samples were collected from 406 HIV-infected women. IL-8 levels were evaluated by ELISA and compared with levels of C. albicans detected by potassium hydroxide (KOH) and PCR. Levels of lactobacilli, Gardnerella vaginalis and Mycoplasma hominis were also determined by PCR. IL-8 was significantly higher in samples from women with Candida, and regression analysis showed a positive association between IL-8 and Candida. In contrast, there was an inverse relationship between lactobacilli and IL-8. G. vaginalis and M. hominis were not significantly associated with IL-8. This study has shown an association between C. albicans and levels of IL-8 in mucosal genital fluid.

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Section: Introductioncontrasting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Vaginal IL-8 levels are positively associated with Candida albicans and inversely with lactobacilli in HIV-infected women

Spear

Zariffard

Cohen

et al. 2008

Journal of Reproductive Immunology

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“…On the other hand, a study including 121 women with twin pregnancies sampled at 24, 26, 28, 30, 32 and 34 weeks of gestation determined that the levels of IL-1alpha and IL-6 in cervicovaginal secretion were not significantly associated with preterm birth [37].…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence suggests that microbes associated with BV modulate the immune response [27,31,[33][34][35][36]. Many authors have found elevate levels of interleukin (IL)-1alpha or beta in vaginal secretions of BV-positive women compared to healthy controls [34,[37][38][39][40]. IL-1beta is a member of the IL-1 family, which includes the classical IL-1alpha (IL-1F1) and IL-1beta (IL-1F2) cytokines, IL-1 receptor antagonist (IL-1ra, or IL-1F3), IL-18 (IL-1F4), and the newly described IL-1F5-11 [41].…”

Section: Introductionmentioning

confidence: 99%

Local Interleukin-1beta in Pregnant Women with Bacterial Vaginosis and Adverse Pregnancy Outcomes

Cauci¹

2016

OGIJ

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Objective: To assess if vaginal interleukin-(IL)-1beta in early pregnancy is associated with adverse outcome among BV-positive women.Study Design: 1,806 women were enrolled at <20 weeks' gestation. 800 women were BV-positive (Nugent 7-10), 707 of them had birth outcome data. Vaginal IL1beta concentrations were measured in 105 BV-positive women who had an adverse preterm outcome, including 66 preterm births (20-<37 weeks, of which 52 were spontaneous) and 14 late miscarriages (12-<20 weeks), and in 295 BV controls (term normal birth weight infants). The upper (>66 th percentile) and lower (<33 rd percentile) tertiles of IL-1beta concentrations were compared with the middle tertile (33 rd to 66 th percentile). Results:None of the IL-1beta tertiles was associated with increased risk for any adverse preterm outcome, nor preterm birth and miscarriage with or without exclusion of women with concurrent STDs.Conclusion: IL-1beta is not a risk marker for preterm birth among BV-positive women in early gestation.

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“…3,4 To prevent prematurity, the ideal course of action would be to predict which patients are at risk of premature delivery and then implement effective intervention. [5][6][7] In several studies, bacterial vaginosis has been associated with prematurity and other adverse outcomes, independent of other known risk factors. [8][9][10][11][12] While bacterial vaginosis has been associated with preterm delivery and low birth weight, randomized trials for the treatment of bacterial vaginosis during pregnancy have not always demonstrated a reduction in such outcomes.…”

Section: Introductionmentioning

confidence: 99%

Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study

et al. 2005

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CONTEXT AND OBJECTIVE: Bacterial vaginosis has been associated with prematurity and other perinatal complications. However, the efficacy of the treatment for preventing such complications has not yet been well established. The objective of this study was to evaluate the impact of treatment for bacterial vaginosis on a low-risk population of Brazilian pregnant women, in order to prevent prematurity and other perinatal complications. DESIGN AND SETTING: Observational retrospective cohort study, at the Obstetric and Gynecology Department, Universidade Estadual de Campinas (Unicamp). METHODS: Vaginal bacterioscopy results from 785 low-risk pregnant women were studied. Three different groups of women were identified: 580 without bacterial vaginosis during pregnancy, 134 with bacterial vaginosis treated using imidazoles (metronidazole, tinidazole, or secnidazole) during pregnancy, and 71 with bacterial vaginosis not treated during pregnancy. The diagnosis of bacterial vaginosis was based on Nugent's criteria, from the vaginal bacterioscopy performed during the first prenatal care visit. RESULTS: The frequency of prematurity was 5.5% among the women without bacterial vaginosis, 22.5% among those with untreated bacterial vaginosis and 3.7% among those with treated bacterial vaginosis. The risk ratios for perinatal complications were significantly higher in the group with untreated bacterial vaginosis: premature rupture of membranes, 7.5 (95% CI: 1.9-34.9); preterm labor, 3.4 (95% CI: 1.4-8.1); preterm birth, 6.0 (95% CI: 1.9-19.7); and low birth weight, 4.2 (95% CI: 1.2-14.3). CONCLUSION: The treatment of bacterial vaginosis significantly reduced the rates of prematurity and other perinatal complications among these low-risk Brazilian pregnant women, regardless of the history of previous preterm delivery.

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Interleukin‐1α, interleukin‐6 and interleukin‐8 in cervico/vaginal secretion for screening of preterm birth in twin gestation

Abstract: IL-8, but not IL-1alpha and IL-6, was associated with preterm delivery but the relationship was too weak to be of predictive value for preterm birth in twin pregnancies. IL-1alpha and IL-8, but not IL-6, were associated with bacterial vaginosis.

Cited by 29 publications

References 27 publications

Vaginal IL-8 levels are positively associated with Candida albicans and inversely with lactobacilli in HIV-infected women

Vaginal IL-8 levels are positively associated with Candida albicans and inversely with lactobacilli in HIV-infected women

Local Interleukin-1beta in Pregnant Women with Bacterial Vaginosis and Adverse Pregnancy Outcomes

Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study

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