Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease

Melo, Rafaela Fernanda; Lopes, Beatriz Maria Valério; Shibli, Jamil Awad; Júnior, Élcio Marcantônio; Marcantonio, Rosemary Adriana Chiérici; Galli, Gloria

doi:10.1111/j.1708-8208.2010.00325.x

Cited by 46 publications

(93 citation statements)

References 37 publications

(81 reference statements)

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“…In addition, Melo et al . did not take into consideration the presence of bone loss when defining implants with peri‐implantitis. Healthy implants were generally specified as having no bone loss and no signs of inflammation.…”

Section: Resultsmentioning

confidence: 99%

Could cytokine levels in the peri‐implant crevicular fluid be used to distinguish between healthy implants and implants with peri‐implantitis? A systematic review

Duarte

Serrão

Miranda

et al. 2016

J of Periodontal Research

106

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Section: Resultsmentioning

confidence: 99%

Could cytokine levels in the peri‐implant crevicular fluid be used to distinguish between healthy implants and implants with peri‐implantitis? A systematic review

Duarte

Serrão

Miranda

et al. 2016

J of Periodontal Research

106

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“…However, some studies did not find a significant difference in the level of IL-1β in the crevicular fluid around healthy teeth and implants17,18. Several studies have reported signi-ficantly higher levels of IL-1β in the crevicular fluid around implants than around healthy teeth11,17,19,20,21.…”

Section: Discussionmentioning

confidence: 99%

Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study

Yaghobee

Khorsand

Ghohroudi

et al. 2014

J Korean Assoc Oral Maxillofac Surg

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ObjectivesThis study aimed to assess and compare the levels of interleukin-1beta (IL-1β) and interleukin-6 (IL-6) in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth.Materials and MethodsThis study evaluated 16 dental implants in 8 patients (4 males and 4 females). These patients had at least one healthy implant and one implant with peri-implantitis next to healthy teeth. The crevicular fluid was collected using absorbent cones and transferred to the laboratory. Specimens were evaluated by ELISA for interleukin levels. Data were analyzed using repeated measures ANOVA and Bonferroni tests (P<0.05).ResultsLevels of IL-1β in the crevicular fluid around implants with peri-implantitis were significantly higher than around healthy implants (P=0.002); the latter was significantly higher than around healthy teeth (P=0.015). A significant difference was found in the level of IL-6 in the crevicular fluid around implants with peri-implantitis and healthy implants (P=0.049) and also between implants with peri-implantitis and healthy teeth (P<0.001).ConclusionWithin the limitations of this study, significant differences exist in the levels of IL-1β and IL-6 in the crevicular fluid of implants with peri-implantitis, healthy implants, and healthy teeth. More studies with larger sample sizes in different populations are necessary.

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“…Studies have also demonstrated that single nucleotide polymorphisms (SNP) in the IL-1 gene may hold an increased risk for the development of peri-implantitis, particularly when combined with smoking (Andreiotelli et al 2008;Bormann et al 2010). However, the presence of a specific SNP does not necessarily translate into higher levels of IL-1β in PICF (Lachmann et al 2007;Jansson et al 2005;Melo et al 2012). Although there is good evidence of the involvement of IL-1β as a crucial mediator of the host inflammatory response in peri-implant tissues (Murata et al 2002;Salvi et al 2010;Ataoglu et al 2002), this needs to be complemented with further interventional studies, whereby IL-1β inhibitors are part of the treatment.…”

mentioning

confidence: 99%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

108

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Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.

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Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease

Abstract: There was no correlation between the concentration of IL-1β and IL-6 in the crevicular sulcular fluid present in healthy or diseased osseointegrated implants in comparison with healthy teeth. The studied gene polymorphisms had no influence on peri-implant disease.

Cited by 46 publications

References 37 publications

Could cytokine levels in the peri‐implant crevicular fluid be used to distinguish between healthy implants and implants with peri‐implantitis? A systematic review

Could cytokine levels in the peri‐implant crevicular fluid be used to distinguish between healthy implants and implants with peri‐implantitis? A systematic review

Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study

Peri-Implant Infections of Oral Biofilm Etiology

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