Interleukin-2 enhances the cytotoxic activity of circulating natural killer cells in patients with chronic heart failure

Yao, Heng‐Chen; Li, Shuqin; Yu, Ke; Zhou, Min; Wang, Lexin

doi:10.1007/s00380-008-1123-0

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Beside changes in B‐cell populations, NK cells were distinctively reduced in CHF patients compared with age‐matched controls in our study, as reported previously . NK cells from patients with heart failure were shown to have impaired cytotoxic functions, and increased regulatory T‐helper cells suppress the cytotoxic function of NK cells in heart failure patients .…”

Section: Discussionsupporting

confidence: 88%

Immunosenescence‐associated microRNAs in age and heart failure

Seeger

Haffez²,

Fischer³

et al. 2013

European J of Heart Fail

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AimsAgeing of the immune system, immunosenescence, is characterized by impaired lymphopoiesis, especially B-lymphocyte maturation, and is a hallmark of chronic heart failure (CHF). MicroRNAs (miRNAs) are non-coding, small RNAs, which post-transcriptionally control gene expression of multiple target genes. The miR-181 family is known to control haematopoietic lineage differentiation. Here, we study the role of the miR-181 family in immunosenescence and CHF. Methods and resultsWe conducted a clinical study analysing peripheral blood (PB) for miRNA expression and leucocyte distribution of young healthy controls (25 + 4 years; n ¼ 30), aged healthy controls (64 + 5 years; n ¼ 13), and age-matched CHF patients (64 + 11years; n ¼ 18). The expression of miR-181 family members was reduced, whereas miR-34a was increased in PB of aged individuals. In particular, miR-181c was further reduced in age-matched CHF patients. In PB, we observed reduced numbers of lymphocytes, in particular cytotoxic T cells and B cells, with rising age, and the expression of miR-181 correlated with the number of B cells. Notably, in CHF patients, ischaemic heart failure was associated with a further reduction of total B cells as well as their subpopulations, such as memory B cells, compared with age-matched healthy volunteers. ConclusionsAgeing-and CHF-associated changes in PB leucocyte subsets are paralleled by alterations in the expression of miRNAs involved in lymphopoiesis, which might play an important role in the age-related and CHF-mediated dysregulation of immune functions resulting in immunosenescence. Furthermore, miR-181c may serve as a marker for reduced immune functions in CHF patients.--

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Section: Discussionsupporting

confidence: 88%

Immunosenescence‐associated microRNAs in age and heart failure

Seeger

Haffez²,

Fischer³

et al. 2013

European J of Heart Fail

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“…In the immune system, NK cell activity is thought to be one of the important indices for monitoring immunity because innate immunity is the first line of defense against infections. It has been shown that NK cell activity is impaired due to various stressors, such as chronic heart failure (40) and high-intensity physical exercise. (41) Moreover, it has been understood that NK cell activity is mediated, at least partially, by nitric oxide-mediated pathways.…”

Section: Discussionmentioning

confidence: 99%

Amino acid and vitamin supplementation improved health conditions in elderly participants

Ohtani

Kawada

Seki

et al. 2012

J. Clin. Biochem. Nutr.

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The purpose of this study was to investigate the effects of supplementation with amino acids and vitamins on health conditions in unhealthy older people. One bedridden inpatient group (n = 10; mean age, 79.8 ± 8.5 y) and one outpatient group (n = 9; mean age, 72.9 ± 12.2 y) participated in this study. A mixture supplementation with amino acids containing arginine (500 mg/day), glutamine (600 mg/day), and leucine (1200 mg/day), and 11 kinds of vitamins was daily administrated for 8 weeks. In both groups, general blood biomarkers such as white blood cell count, natural killer cell activity, and C-reactive protein levels were measured. All measurements were taken before (baseline), at 4 weeks (mid-point), and after each trial (post-point). At mid-point, natural killer cell activity in the outpatient group increased significantly compared to baseline. At post-point, natural killer cell activity in the outpatient and inpatient groups increased significantly compared to baseline. The other blood biomarkers did not show any significant change throughout the trial. This pilot study suggested that a mixture of arginine, glutamine, leucine, and vitamins is useful to support innate immunity in unhealthy older people, even if their diseases, symptoms, and prescribed medicines are different.

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Serum concentrations of interleukin-4 and interferon-gamma in relation to severe left ventricular dysfunction in patients with acute myocardial infarction undergoing percutaneous coronary intervention

Szkodziński¹,

Hudzik²,

Osuch³

et al. 2010

Heart Vessels

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Many studies have suggested an imbalance between proinflammatory and anti-inflammatory markers in acute myocardial infarction (AMI). Interleukin 4 (IL-4) shows mainly anti-inflammatory activities. Interferon-gamma (IFN-γ) is a proinflammatory cytokine secreted by Th1 lymphocytes. Severe systolic left ventricular (LV) dysfunction following AMI is one of the major risk factors for poor prognosis. The aim of this study was to evaluate whether IL-4 and IFN-γ concentrations can serve as the correlates of impaired left ventricular function. Fifty-three patients with AMI were enrolled and divided into two groups depending on their ejection fraction (EF): group 1 with EF ≤ 30% (N = 10) and group 2 with EF >30% (N = 43). All patients underwent coronary angiography followed by percutaneous coronary intervention (PCI). Blood samples were taken (1) before, (2) immediately after, (3) 2 h after, and (4) 72 h after PCI. A receiver-operating characteristic (ROC) analysis was planned to identify possible cutoff values to predict LV dysfunction. There was no sex difference between the two groups. The rate of hypertension and diabetes mellitus was also similar. Median concentrations for IL-4 (pg/ml) were: (1) 13.4 versus 17.2 (p = 0.0001), (2) 16.8 versus 18.6 (p = 0.01), (3) 17.2 versus 17.6 (p = NS), and (4) 17.6 versus 17.2 (p = NS). Median concentrations for IFNγ (pg/ml) were: (1) 0.3 versus 1.9 (p = 0.00001), (2) 2.1 versus 1.6 (p = NS), (3) 0.4 versus 0.9 (p = NS), and (4) 0.9 versus 1.1 (p = NS). The area under the ROC curve (AUC) analysis is presented in the table below. Reported results suggest the high diagnostic value of IL-4 measurements before and immediately after PCI as the correlates of impaired LV dysfunction, whereas only IFN-γ measurement before PCI had a high diagnostic value. Measurements performed later on have no predictive value. Cutoff value AUC Sensitivity (%) Specificity (%) PPV (%) NPV (%) p IL-4 (a) ≤ 15.0 0.89 100 79 52 100 0.0001, IL-4 (b) ≤ 17.2 0.75 100 67 42 100 0.0007, IFNγ (a) ≤ 0.3 0.94 100 91 71 100 0.0001.

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Interleukin-2 enhances the cytotoxic activity of circulating natural killer cells in patients with chronic heart failure

Cited by 4 publications

References 15 publications

Immunosenescence‐associated microRNAs in age and heart failure

Immunosenescence‐associated microRNAs in age and heart failure

Amino acid and vitamin supplementation improved health conditions in elderly participants

Serum concentrations of interleukin-4 and interferon-gamma in relation to severe left ventricular dysfunction in patients with acute myocardial infarction undergoing percutaneous coronary intervention

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