Interleukin 28B rs12979860 genotype and Human Immunodeficiency Virus type 1: Susceptibility, AIDS development and therapeutic outcome

IFNL4 genotype influences the rate of HIV-1 seroconversion in men who have sex with men

“…They found no association with protection in highly exposed seronegative individuals. Similar results were found in a North African population [ 11 ]. However, these studies did not genotype the functional INDEL located in the open reading frame of the IFNL4 but another SNP in the first intron.…”

“…Finally, studies that tested rs12979860 in populations of African ancestry were not included in the meta-analysis. Two studies comprising African-American [ 10 ] and Moroccan [ 11 ] individuals were excluded in the meta-analysis since they tested the rs12979860 SNP located in the first intron instead of the functional INDEL rs368234815 located in the protein-coding region of IFNL4 . Europeans and Asians show complete linkage disequilibrium for both genetic polymorphisms, that is not the case for it for African populations where both genetic markers are genetically independent.…”

Lack of Association between IFNL3 Polymorphism and Human Papillomavirus Infection and Their Progression in HIV-Infected Women Receiving Antiretroviral Treatment

“…The rs12979860-T allele is in strong linkage disequilibrium with IFNL4-ΔG [38]. Moreover, no association was found in other infectious diseases such as spontaneous viral clearance of hepatitis B virus [39][40][41][42], human T-cell leukemia virus type 1 outcomes [43], and HIV infection [39,[44][45][46][47][48]. These results are in contrast with those previously reported in HCV infection where a significant association between the CC genotype and higher spontaneous recovery rates of acute HCV infection was found [28,30,[49][50][51].…”

Association of interleukin‐27 gene polymorphisms with susceptibility to HIV infection and disease progression

“…In other studies, Rosalinda et al showed that rs40837A alleles were significantly associated with a decreased risk of pCAD, Si F et al found a significant increase in the risk of Kawasaki disease with coronary arterial lesions in children with rs40837, and Jesus et al conferred no association between rs40837 and UC, a possible explanation might be rs40837 exists genetic heterogeneity in different diseases. Of note, there are also some researches investigating association between polymorphisms of other interleukins such as IL‐10 and IL‐28B and HIV infection, and the results are different and even conflicting. In accordance with our further study, we found that IL‐27 rs40837 polymorphisms may be related to disease progression of HIV infection.…”

“…It is clear that CD4 + T counts were associated with changes in serum IL-27,30 after positive association between IL-27 and CD4 + T counts performed in this study, we were surprised to found the difference of CD4 + T counts between individuals with homozygotes of major allele AA and heterrozygote AG in IL-27 rs40837 was obvious, CD4 + T counts in AG carriers were lower than AA carriers, which might explain the individuals carrying AG of rs40837 had a increased risk of infecting HIV. In a similar literature, Imane Zai et al23 have ever investigated the association of IL28B variation and CD4 + T count in AIDS individuals, and they came to a decision that rs12979860 polymorphism may affect the response to treatment as measured by CD4 + T cell counts. On the other hand, evidence have suggested that CD8 + T cells are involved in the control of virus replication during HIV infection31 and IL-27 can enhance the activation and proliferation of CTL after being infected by HIV 32.…”