Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis

Kuzumi, Ai; Yoshizaki, Ayumi; Matsuda, Kazuki; Kotani, Hirohito; Norimatsu, Yuta; Fukayama, Masahisa; Ebata, Satoshi; Fukasawa, Takemichi; Yoshizaki‐Ogawa, Asako; Asano, Yoshihide; Morikawa, Kyojiro; Kazoe, Yutaka; Mawatari, Kazuma; Kitamori, Takehiko; Sato, Shinichi

doi:10.1038/s41467-021-26099-w

Cited by 57 publications

(36 citation statements)

References 57 publications

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“… 114 IL-31Ra seems to be upregulated in surrounding tissue cells during the SSc disease state, showing that this axis is likely stimulated in an aberrant manner. 115 IL-33 has been studied as a disease marker in SSc. It follows the disease state of SSc tightly, with increases in affected individuals, and whose drops correlate well with treatment efficacy.…”

Section: Discussionmentioning

confidence: 99%

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Tatu¹,

Nadasdy²,

Arbune³

et al. 2022

JIR

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The interrelations and sequencing of interleukins are complex (inter)actions where each interleukin can stimulate the secretion of its preceding interleukin. In this paper, we attempt to summarize the currently known roles of IL-4, IL-13, IL-31, and IL-33 from a multi-disciplinary perspective. In order to conduct a comprehensive review of the current literature, a search was conducted using PubMed, Google Scholar, Medscape, UpToDate, and Key Elsevier for keywords. The results were compiled from case reports, case series, letters, and literature review papers, and analyzed by a panel of multi-disciplinary specialist physicians for relevance. Based on 173 results, we compiled the following review of interleukin signaling and its clinical significance across a multitude of medical specialties. Interleukins are at the bed rock of a multitude of pathologies across different organ systems and understanding their role will likely lead to novel treatments and better outcomes for our patients. New interleukins are being described, and the role of this inflammatory cascade is still coming to light. We hope this multi-discipline review on the role interleukins play in current pathology assists in this scope.

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Section: Discussionmentioning

confidence: 99%

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Tatu¹,

Nadasdy²,

Arbune³

et al. 2022

JIR

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“…Overexpression of IL-31 and IL-31 receptors has been shown by Yaseen et al, in the case of SSc. 134 IL-32.-IL-32 is a pro-inflammatory cytokine having a molecular weight of 22 kDa, and its signaling via a mitogen-activated protein kinase (MAPK), p38, and NF-κB are linked with many autoimmune diseases such as inflammatory disorders, RA, IBD, ulcerative colitis, Crohn's disease, etc. 133 It is predicted to have its role against intracellular pathogens by developing resistance against them.…”

Section: Ils: Types and Expressionmentioning

confidence: 99%

Review—Interleukins Profiling for Biosensing Applications: Possibilities and the Future of Disease Detection

et al. 2022

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Interleukins (ILs) are a major subclass of cytokines which act as molecular messengers playing a role in immune system responses via cascade of signalling pathways. Belonging to the cytokine family, ILs play a crucial role in the theronostics of various diseases. Their abnormal expression leads to development of various diseases such as cancer, neurodegenerative diseases, allergies, asthma, autoimmune diseases, and other physiological abnormalities. This paves the way for exploring ILs to develop sensitive and efficient biosensors, and promoting them for clinical testing in a wide array of diseases. Furthermore, detecting the level of ILs is very important for their early diagnosis and their progression within the body, and simultaneously for possible immunotherapeutic approaches. To achieve this goal, multidisciplinary scientific approaches involving immunology, electrochemistry, nanotechnology, photometry, etc. are already being put into action. Advancements in nanoscience and nanotechnology are aiding in the development of highly sensitive biosensors for ILs detection. This review focuses on a detailed description of all presently discovered ILs and their roles in various diseases. Simultaneously, it also discusses the various electrochemical biosensors that can be employed for the detection of ILs in bodily fluids. Moreover, the role of nanomaterials in electrochemical biosensing are also discussed here.

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“…The present analysis using these new methods has revealed the function of autoantigen-reactive B cells, which had been a black box. These new findings are expected to be applicable to other autoimmune diseases, including PPP, suggesting the possibility of creating a new etiology for autoimmune diseases as a whole, including neutrophils [ 71 ].…”

Section: Latest Researchmentioning

confidence: 99%

Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases

Fukasawa

Yoshizaki‐Ogawa

Enomoto

et al. 2022

IJMS

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Palmoplantar pustulosis (PPP) is a disease that causes recurrent blisters and aseptic pustules on the palms and soles. It has been suggested that both innate and acquired immunity are involved. In particular, based on the tonsils and basic experiments, it has been assumed that T and B cells are involved in its pathogenesis. In addition, the results of clinical trials have suggested that IL-23 is closely related to the pathogenesis. This review describes PPP and the genetic background, the factors involved in the onset and exacerbation of disease and its relation to the molecular mechanism. In addition, we describe the usefulness of biological therapy and its implications in relation to the importance in pathology, the pathogenesis of PPP, the importance of the role of the IL-23–Th17 axis and IL-36 in PPP. Furthermore, we describe an animal experimental model of PPP, the efficacy and mechanism of action of guselkumab, an anti-IL-23 antibody, the latest research, and finally the possibility for it to be effective for other autoimmune diseases.

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Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis

Cited by 57 publications

References 57 publications

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Review—Interleukins Profiling for Biosensing Applications: Possibilities and the Future of Disease Detection

Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases

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