Interleukin-33: A Multifunctional Alarmin that Promotes Both Health and Disease

Matsushita, Kazunobu; Yoshimoto, Tomohiro

doi:10.1007/978-4-431-54442-5_11

Cited by 5 publications

(3 citation statements)

References 125 publications

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“…IL-33 is an epithelial cell-derived pleiotropic cytokine whose receptor is expressed on variety of cells including T cells, DCs, basophils and mast cells (31). Although our data showed the partial involvement of IL-33 in the initiation of T h 2 responses in the skin, Il33 −/− mice developed serum OVA-specific IgE comparable to WT mice.…”

Section: Role Of Basophils Tslp and Il-33 In Food Allergy 547mentioning

confidence: 49%

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The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy

Muto

Fukuoka

Kabashima

et al. 2014

International Immunology

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109

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Cutaneous sensitization with a food antigen before its consumption elicits the development of food allergy. Here, we report the site- and stage-dependent roles of basophils and proallergic cytokines, thymic stromal lymphopoietin (TSLP) and IL-33, in a mouse model of food allergy initially sensitized cutaneously with the food antigen. Mice were epicutaneously sensitized with the food antigen ovalbumin (OVA) followed by oral challenge with OVA. Epicutaneously sensitized mice produced OVA-specific IgE and developed IgE-dependent anaphylaxis after oral challenge. Basophil-depleted or TSLP-receptor-deficient mice did not produce OVA-specific IgE and were protected from oral challenge-induced anaphylaxis. IL-33-deficient mice produced normal levels of OVA-specific IgE. However, IL-33-deficient mice and mice treated with recombinant soluble IL-33 receptor were protected from anaphylaxis. Thus, basophils and TSLP have pivotal roles in Th2 development in the skin during the sensitization phase of food allergy. In contrast, while IL-33 is dispensable for promoting cutaneous antigen sensitization, the cytokine is essential for inducing IgE-dependent anaphylaxis in the gut.

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Section: Role Of Basophils Tslp and Il-33 In Food Allergy 547mentioning

confidence: 49%

“…Recent studies demonstrated the important role of IL-33 in T h 2-type immune-mediated diseases (31). Importantly, IL-33 may participate in both skin (32,33)-and gut (34-36)-mediated T h 2-type immune responses.…”

Section: Introductionmentioning

confidence: 99%

The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy

Muto

Fukuoka

Kabashima

et al. 2014

International Immunology

Self Cite

109

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“…Interleukin‐33 is present in the nucleus of cells and is released by cell necrosis or cytotoxicity 4,5 . It acts as an alarmin to stimulate ILC2 to produce type 2 cytokines 6 and directly enhances adhesion of eosinophils 7 . The IL‐5 produced by ILC2 can be recruited to the fascia, because IL‐5‐producing T cells congregate at the site of induced inflammation and induce eosinophil activity and maturation locally 8 .…”

Section: Ilc2‐mediated Eosinophilic Fasciitismentioning

confidence: 99%

Eosinophilic fasciitis induced by a game of drumming probably via type 2 innate immunity

et al. 2022

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We report a case of eosinophilic fasciitis triggered by strenuous physical activity, which did not relapse during the follow‐up period. We ascertained that interleukin‐33 (IL‐33) was released from the vascular endothelial cells after intense exercise, inducing type 2 innate lymphocytes (ILC2) and causing fasciitis. A healthy woman experienced itching on both limbs a few hours after a game of drumming. Her hand, knee joints, and legs gradually swelled up with groove signs along the superficial veins. White blood cell and eosinophil counts were significantly elevated. Magnetic resonance imaging revealed a high signal at the fascia on both lower limbs. Histopathological findings of the left lower limb tissue specimen showed edematous fascia with eosinophils. No relapse of eosinophilic fasciitis was observed after finishing treatment with prednisolone. Immunological staining for IL‐4, IL‐5, IL‐33, tumor necrosis factor‐α, and interferon‐γ was performed on the fascial tissue. Both IL‐4 and IL‐5 were stained on the lymphocytes at the muscle and fascia levels; however, CD3 and CD4 were unstained in these cells, suggesting that those cells were ILC2. Tumor necrosis factor‐α and interferon‐γ were unstained. Vascular endothelial cells in the fascia strongly expressed IL‐33. Eosinophilic fasciitis may be associated with type 2 immunity triggered by IL‐33 in the current case.

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The Effect of Dexamethasone on Il-33-Mediated Mast Cell Activation

Chernushevich

2015

VCU Theses and Dissertations

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Interleukin-33: A Multifunctional Alarmin that Promotes Both Health and Disease

Cited by 5 publications

References 125 publications

The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy

The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy

Eosinophilic fasciitis induced by a game of drumming probably via type 2 innate immunity

The Effect of Dexamethasone on Il-33-Mediated Mast Cell Activation

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