2020
DOI: 10.1007/s10620-020-06077-w
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Interleukin-35 Suppresses CD8+ T Cell Activity in Patients with Viral Hepatitis-Induced Acute-on-Chronic Liver Failure

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Cited by 21 publications
(22 citation statements)
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“…Although we did not find correlation between IL-35 and IL-9 production in CHB or hepatitis B-related HCC patients, our current data still suggested that elevation of IL-35 suppresses HBV-specific Th9 activity during chronic HBV infection. Thus, IL-35 not only eliminated the function of CD8 + T cells in a direct way ( 12 , 14 , 16 ), but also reduced IL-9 production by CD4 + T cells, and in turn, would lead to a suppression in CD8 + T cell-mediated cytotoxicity in hepatitis and HCC patients. The contrary role of IL-35 in regulation of Th9 cell function might be due to the different immune status between autoimmune disorder and chronic infection.…”
Section: Discussionmentioning
confidence: 99%
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“…Although we did not find correlation between IL-35 and IL-9 production in CHB or hepatitis B-related HCC patients, our current data still suggested that elevation of IL-35 suppresses HBV-specific Th9 activity during chronic HBV infection. Thus, IL-35 not only eliminated the function of CD8 + T cells in a direct way ( 12 , 14 , 16 ), but also reduced IL-9 production by CD4 + T cells, and in turn, would lead to a suppression in CD8 + T cell-mediated cytotoxicity in hepatitis and HCC patients. The contrary role of IL-35 in regulation of Th9 cell function might be due to the different immune status between autoimmune disorder and chronic infection.…”
Section: Discussionmentioning
confidence: 99%
“…Our previous reports demonstrated peripheral and liver-infiltrating CD8 + T cell exhaustion in chronic hepatitis B ( 12 ), non-viral hepatitis-related HCC ( 14 ), and viral hepatitis-related acute-on-chronic liver failure ( 16 ). The current in vitro data also supported that peripheral CD8 + T cells from hepatitis B-related HCC patients revealed CD8 + T cell dysfunction in both non-specific and HBV-specific manner.…”
Section: Discussionmentioning
confidence: 99%
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“…A recent study[ 31 ] suggested that T-cell-mediated immune response plays a vital role in acute HBV infection and the pathogenesis of HBV-related ACLF, which suggests that T-cell responses play a crucial role in virus control and immune-mediated liver damage. Another recent study[ 32 ] showed that chronic HBV and HCV infections always lead to T-cell depletion or dysfunction, which results in immune tolerance and viral persistence. The pathogenesis of ACLF is also a dysfunctional immune response caused by systemic inflammation and increased immune cell paralysis.…”
Section: Discussionmentioning
confidence: 99%
“…Recombinant IL-35 can stimulate Breg cells to secrete IL-10 and IL-35 26 , 27 . Interestingly, Recombinant IL-35 stimulation can dampene cytotoxicity and interferon-γ production in both direct and indirect contact co-culture systems in viral hepatitis-induced acute-on-chronic liver failure 47 . For further understanding the role of IL-35-producing B cells in mycobacterial infection, exogenous recombinant IL-35 was used in this study to treat BCG-infected mice, and its effects were validated.…”
Section: Discussionmentioning
confidence: 99%