Interleukin-4 signalling pathway underlies the anxiolytic effect induced by 3-deoxyadenosine

Gao, Tangxin; Li, Bai; Hou, Yachen; Luo, Shaolei; Feng, Lei; Nie, Jun; Ma, Yue; Xiao, Le; Xu, Chang; Bao, Hongkun; Xian-min, LU; Huang, Feilong; Wang, Gang; Xiao, Chunjie; Du, Jing

doi:10.1007/s00213-019-5186-7

Cited by 10 publications

(8 citation statements)

References 48 publications

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“…Endogenous IL-4 is expressed mainly in neurons, although small amounts co-localize with GFAP-positive cells and Iba1-immunoreactive cells 4 . Our study shows that 3'-dA exhibited a rapid and stable anxiolytic effect in the mice behavioural tests via activating the IL-4 pathway, regulating the expression levels of the IL-10 IL-1β and TNF-α in PFC, 10 , suggesting 3'-dA functions to correct the imbalance between proinflammatory factors and anti-inflammatory factors, which is helpful for restraining inflammatory reactions, activating anti-inflammatory factor pathways, and promoting neuralfunctional repair in the CNS.…”

mentioning

confidence: 61%

“…. In recent study, we found that 3'-dA treatments significantly increased IL-4 expression in neurons, and IL-4 expression strongly correlated with the parameters representing reduced anxiety behaviours, suggesting that expression of the key anti-inflammatory molecule IL-4 is critical for the anxiolytic effect 10 . In addition, both 3'-dA and traditional anxiolytic imipramine enhanced the expression levels of IL-4 and IL-10, and decreased the expression levels of IL-1β and TNF-α, synchronous with the anxiolytic effects produced after chronic treatment for 5 days.…”

mentioning

confidence: 88%

“…In addition, both 3'-dA and traditional anxiolytic imipramine enhanced the expression levels of IL-4 and IL-10, and decreased the expression levels of IL-1β and TNF-α, synchronous with the anxiolytic effects produced after chronic treatment for 5 days. The blockade of IL-4 action using the specific inhibitor RIL-4Rα prevented the anxiolytic effect of both 3'-dA and imipramine, indicating that correction of imbalance of proinflammatory and anti-inflammatory pathways is the common mechanism for the treatment of anxiety disorders 10 . Other anxiolytics, including diazepam, oryzanol, and chlordiazepoxide were shown enhancing anti-inflammatory cytokines and inhibiting pro-inflammatory cytokines in support of the findings [13][14][15][16] .…”

mentioning

confidence: 98%

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Neuroimmune Imbalance: The Key for the Treatment of Anxiety?

Li¹,

Gao²,

Du³

2019

J Immunological Sci

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Anxiety disorder, a common mood disorder, seems associated with neuro-immune aberration on the pathophysiology, revealed by many clinical and preclinical evidences [1][2][3][4][5] . Furthermore, previous research suggested that the prefrontal cortex (PFC) is a critical brain region involved in anxiety disorders [6][7][8][9] . Now, we show that to keep the balance of pro-inflammatory immune-status and the anti-inflammatory immune-status in the PFC is the key for the treatment of anxiety 10 .3'-deoxyadenosine (3'-dA), one of the major bioactive metabolites in the Cordyceps Militaris, possesses multiple beneficial effects of anti-inflammatory, anti-cancer, anti-viral, and anti-fungal activities 11,12

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confidence: 61%

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confidence: 88%

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confidence: 98%

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Neuroimmune Imbalance: The Key for the Treatment of Anxiety?

Li¹,

Gao²,

Du³

2019

J Immunological Sci

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“…The authors further evaluated the possible mechanism and found that cordycepin could increase IL-4 and IL-10 expression and decrease TNF-α and IL-1β expression in prefrontal cortex. IL-4 expression has now been demonstrated to be very strongly positively correlated with reduced anxiety (Gao et al, 2019).…”

Section: Cordycepinmentioning

confidence: 97%

Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin

et al. 2020

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Cordyceps militaris (C. militaris) is a fungus with a long history of widespread use in folk medicine, and its biological and medicinal functions are well studied. A crucial pharmacological effect of C. militaris is immunomodulation. In this review, we catalog the immunomodulatory effects of different extracts of C. militaris, namely total extracts, polysaccharides and cordycepin. Total extracts obtained using water or 50% ethyl alcohol and polysaccharides from C. militaris were discovered to tend to promote type 1 immunity, whereas total extracts obtained using 70–80% ethyl alcohol and cordycepin from C. militaris were more likely to promote type 2 immunity. This article is the first to classify the immunomodulatory effects of different extracts of C. militaris. In addition, we discovered a relationship between different segments or extracts and differing types of immunity. This review can provide the readers a comprehensive understanding on the immunomodulatory effects of the precious folk medicine and guidance on its use for both health people and those with an immunodeficiency.

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“…Interleukin-4 and IL-10 are pleiotropic anti-inflammatory cytokines that function mainly by suppressing the proinflammatory milieu [19], when DNase degrades DNA in the abscess or NETs, the degradation products, monophosphate nucleotides, become substrate for another enzyme, adenosine synthase A (AdsA) that converts the degraded DNA to deoxyadenosine, which induces caspase-3 activation, leading to apoptosis of macrophages surrounding the abscess or the NET [19] . Gao et al (2019), [20] showed that deoxyadenosine is one of the major bioactive metabolites that possesses multiple beneficial effects of anti-inflammatory, anticancer, anti-viral, and anti-fungal activities in addition and Deoxyadenosine enhanced the expression levels of IL-4 and IL-10, and decreased the expression levels of IL-1β and TNF-α.…”

Section: Determination the Level Of Cytokines Il-10 And Il-4mentioning

confidence: 99%

Effect of Staphylococcus aureus Thermostable DNase on Some Immunological Parameters

Noor Naeem Khwen,

Sawsan Hassan Authman,

Mohammed Faraj AL- Marjani

2021

Indian Journal of Forensic Medicine & Toxicology

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Thermostable DNase was purified from Staphylococcus aureus isolated from local clinical source. The current study includes different immunological assays to evaluate the role of purified DNase. The phagocytic activity showed that the group of mice infected with P.aeruginosa recorded the highest values with significant differences (P <0.05) in comparison with the group that received mixed injection of 1 µg /ml of DNase and P. aeruginosa showed decrease in phagocytic activity followed by group that injected by 1 µg /ml DNase only with phagocytic activity 2%. DNase has a positive immunomodulatory effect on IL-10 and IL-4 level. The data showed that the highest value of IL-10 is in group that injected with 1 µg /ml DNase only (IV group) was 86.79±1.68. While the highest value of IL-4 was in group that injected with both DNase (1 µg /mouse) and P.aeruginosa gave the highest values (III group) was 84.02 ±1.19. In Arthus reactions(Immediate type hypersensitivity), the group that have been injected with both DNase and P. aeruginosa (group III ) gave the highest values (4.50±0.70) while in delayed type hypersensitivity the same group III showed higher values after 24 and 48 hrs (5.00±0.00) , (4.00±0.00) respectively.

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Interleukin-4 signalling pathway underlies the anxiolytic effect induced by 3-deoxyadenosine

Cited by 10 publications

References 48 publications

Neuroimmune Imbalance: The Key for the Treatment of Anxiety?

Neuroimmune Imbalance: The Key for the Treatment of Anxiety?

Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin

Effect of Staphylococcus aureus Thermostable DNase on Some Immunological Parameters

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