Interleukin-5 and interleukin-10 are major cytokines in cerebrospinal fluid from patients with active neurocysticercosis

Rodrigues, Vanessa Gregório; de-Mello, F.A.; Magalhães, E.P.; Ribeiro, S.; Marquez, J.O.

doi:10.1590/s0100-879x2000000900011

Cited by 26 publications

(28 citation statements)

References 19 publications

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“…Embora na literatura não haja relatos anteriores sobre esse processo patológico, sabe-se que várias substâncias, geralmente de natureza protéica, podem sofrer transformação e se depositarem como beta-fibrilas, dentre elas as imunoglobulinas e as citocinas. Rodrigues Jr e cols 27 demonstraram elevados níveis de citocinas no líquor de pacientes com neurocisticercose. Assim, conclui-se que pelo menos parte das beta-fibrilas encontradas possa estar relacionada à elevação dos níveis de interleucinas.…”

Section: Resultsunclassified

Características evolutivas do Cysticercus cellulosae no encéfalo e no coração humanos

Lino

Ribeiro

Antonelli

et al. 2002

Rev. Soc. Bras. Med. Trop.

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Resumo O presente estudo teve como objetivos avaliar a prevalência de cisticercose, classificar as etapas evolutivas dos cisticercos encontrados nos encéfalos e corações humanos, diferenciá-las de acordo com os aspectos macro e microscópicos dos processos patológicos gerais e comparar os processos encontrados nos encéfalos e corações. Foram revisados protocolos de autópsias realizadas no Hospital Escola da Faculdade de Medicina do Triângulo Mineiro, Uberaba, MG, Brasil, no período de 1970 a 2000. Verificou-se a prevalência da cisticercose em 71 casos, sendo 18 (25,4%) de cisticercose cardíaca e 53 (74,6%) de encefálica. Foram analisados 19 cisticercos, sendo 9 de encéfalos e 10 de corações. Os cisticercos foram classificados, de acordo com sua fase evolutiva, em etapas: vesicular, vesicular coloidal, granular nodular e nodular calcificada, com similaridade entre os diagnósticos macro e microscópico. Entre os processos patológicos destacaram-se a beta-fibrilose e a fibroelastose endocárdica. Adicionalmente, demonstrou-se que a classificação pode ser aplicada tanto na cisticercose encefálica como na cardíaca. Palavras-chaves: Cisticercose cardíaca. Classificação da cisticercose. Neurocisticercose. Beta-fibrilose. AbstractThe present study aimed to evaluate the prevalence of cysticercosis, to classify the developmental phases of cysticerci found in human brains and hearts, and differentiate these according to the macro and microscopic aspects of the general pathological processes, and to compare the process found in the brains and hearts. Protocols from autopsies performed at the Hospital of the School of Medicine of the Triângulo Mineiro, Uberaba, MG, Brazil, in the period from 1970 to 2000 were reviewed. The prevalence of cysticercosis was verified in 71 cases, of which 53 (74.6%) were encephalic cysticercosis and 18 (25.3%) cardiac cysticercosis. Nineteen cysticerci were analyzed, from 9 brains and 10 hearts. The cysticerci were classified according to their developmental stage: vesicular, colloidal vesicular, granular nodular and calcified nodular, with similarities between the macroscopic and microscopic diagnoses. Among the pathological processes found beta-fibrilosis and endocardial fibroelastosis are underscored. In addition, it was demonstrated that this classification may be applied both to encephalic and cardiac cysticercosis. Key-words: Cardiac cysticercosis. Classification of cysticercosis. Encephalic cysticercosis. Beta-fibrilosis. A teníase e a cisticercose são afecções produzidas pelas fases adultas e larvárias de helmintos da família Taenidae. Existem duas espécies que afetam humanos (Taenia solium e T. saginata), que necessitam de dois hospedeiros distintos para completarem seus ciclos de vida. Os humanos são os hospedeiros definitivos para o estado adulto de ambas as espécies de tênias, enquanto os suínos e bovinos são os hospedeiros intermediários para os estágios larvários desses parasitas 11 23 . Os humanos, bovinos ou suínos se infectam ao ingerirem os ovos dos parasitas presentes em alimento...

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Section: Resultsunclassified

Características evolutivas do Cysticercus cellulosae no encéfalo e no coração humanos

Lino

Ribeiro

Antonelli

et al. 2002

Rev. Soc. Bras. Med. Trop.

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“…Severe NCC is accompanied with increased eosinophilic infiltration in CSF and production of mixed Th1/Th2 cytokines (IL-5, IL-6 and IL-10). Disease severity increases with the number of cysticerci as patients having multiple cysts show higher expression of IL-5 and IL-6 than patients having single cyst [15][16][17]. Increased expressions of IgG, IgM, IgE, IL-1β, IL-6 and TNF-α were observed in the patients having cysts in the subarachnoid spaces.…”

Section: Cns Immune Response and Cytokinesmentioning

confidence: 99%

“…These alterations also exist with different stage, number and location of the cysts. The expression of both anti-and pro-inflammatory cytokines at the chronic NCC at necropsy and in CSF may be responsible for the heterogeneity in disease outcome [15,17].…”

Section: Cns Immune Response and Cytokinesmentioning

confidence: 99%

Immunopathogenesis of Neurocysticercosis: Role of Cytokines

Singh¹

2015

Immunome Res

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Neurocysticercosis (NCC) is caused by the larva of Taenia solium, when it is lodged in the central nervous system (CNS). NCC is identified as the major cause of community acquired epilepsy, especially in the developing countries. It is also increasingly being reported in the developed world due to human migration from the disease endemic countries. However, some individuals with similar NCC lesions may remain asymptomatic and the reason for this asymptomatic status largely remains unknown. However, studies from our center suggest that cytokines play important role in disease pathogenesis. In the present review, we have discussed the role of different cytokines in the pathogenesis of NCC in human.

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“…23,24 It has also been reported that IL-5 and IL-10 predominated in the cerebrospinal fluid (CSF) of patients with active NCC. 25 Cysteine, aspartic, and metalloprotease activities have been characterized in excretory/secretory (E/S) antigens from T. solium metacestodes. 26,27 Live metacestodes may release such proteases for parasite nutrition, and they may also induce a humoral immune response in the host.…”

Section: Introductionmentioning

confidence: 99%

Discrimination between active and inactive neurocysticercosis by metacestode excretory/secretory antigens of Taenia solium in an enzyme-linked immunosorbent assay.

Molinari¹,

García-Mendoza²,

Garza³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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Abstract. To detect IgG antibodies to Taenia solium, a controlled double-blind study was conducted using 91 coded cerebrospinal fluid samples from patients with neurocysticercosis (NCC) and other neurologic disorders. Samples were tested in an enzyme-linked immunosorbent assay (ELISA) using metacestode excretion/secretion antigens. The results were correlated with data from medical records on the diagnosis of NCC (based on computed tomography and magnetic resonance imaging criteria) and other neurologic disorders. The ELISA results were positive in 22 of the 24 cases with active NCC. In contrast, six cases with calcified cysts (inactive NCC), as well as one case in a transitional stage, were negative. One case with a calcified granuloma and another with a granuloma plus calcifications (classified as inactive NCC) had positive results. The remaining negative results corresponded to other neurologic disorders (58 cases). The results of the ELISA showed a significant difference between active and inactive NCC (P ‫ס‬ 0.0034).

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Interleukin-5 and interleukin-10 are major cytokines in cerebrospinal fluid from patients with active neurocysticercosis

Cited by 26 publications

References 19 publications

Características evolutivas do Cysticercus cellulosae no encéfalo e no coração humanos

Características evolutivas do Cysticercus cellulosae no encéfalo e no coração humanos

Immunopathogenesis of Neurocysticercosis: Role of Cytokines

Discrimination between active and inactive neurocysticercosis by metacestode excretory/secretory antigens of Taenia solium in an enzyme-linked immunosorbent assay.

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